Search Results - "Kandel, Denise B."

Intergenerational Patterns of Smoking and Nicotine Dependence Among US Adolescents by Kandel, Denise B, Griesler, Pamela C, Hu, Mei-Chen

“…We examined associations between parental and adolescent smoking and nicotine dependence in the United States. We used data from the 2004 to 2012 National…”
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Epidemiology and Correlates of Daily Smoking and Nicotine Dependence Among Young Adults in the United States by Hu, Mei-Chen, Davies, Mark, Kandel, Denise B

“…We describe the epidemiology of smoking behaviors in a national young adult sample and identify common and unique demographic, social, and psychological…”
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Synaptoproteomic Analysis of the Prefrontal Cortex Reveals Spatio-Temporal Changes in SYNGAP1 Following Cannabinoid Exposure in Rat Adolescence by Qvist, Johanna S, Scherma, Maria, Jayaram-Lindström, Nitya, Fratta, Walter, Kandel, Denise B, Kandel, Eric R, Fadda, Paola, Melas, Philippe A

“…The regular use of cannabis during adolescence has been associated with a number of negative life outcomes, including psychopathology and cognitive…”
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Educational attainment and smoking among women: Risk factors and consequences for offspring by Kandel, Denise B, Griesler, Pamela C, Schaffran, Christine

“…Abstract We examine the association between education and smoking by women in the population, including smoking during pregnancy, and identify risk factors for…”
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Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats by Melas, Philippe A., Qvist, Johanna S., Deidda, Matteo, Upreti, Chirag, Wei, Ya Bin, Sanna, Fabrizio, Fratta, Walter, Scherma, Maria, Fadda, Paola, Kandel, Denise B., Kandel, Eric R.

“…Reduced eukaryotic Initiation Factor 2 (eIF2)α phosphorylation (p-eIF2α) enhances protein synthesis, memory formation, and addiction-like behaviors. However,…”
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Cytoplasmic Polyadenylation Element Binding Proteins CPEB1 and CPEB3 Regulate the Translation of FosB and Are Required for Maintaining Addiction-Like Behaviors Induced by Cocaine by Drisaldi, Bettina, Colnaghi, Luca, Levine, Amir, Huang, YanYou, Snyder, Anna M., Metzger, Daniel J., Theis, Martin, Kandel, Denise B., Kandel, Eric R., Fioriti, Luana

“…A recurrent and devastating feature of addiction to a drug of abuse is its persistence, which is mediated by maladaptive long-term memories of the highly…”
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Extent of smoking and nicotine dependence in the United States: 1991–1993 by Kandel, Denise B., Chen, Kevin

“…Rates of nicotine dependence vary in different sociodemographic groups in the population. These group differences remain to be understood. The objective of…”
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Increases from 2002 to 2015 in prescription opioid overdose deaths in combination with other substances by Kandel, Denise B., Hu, Mei-Chen, Griesler, Pamela, Wall, Melanie

“…•22% of increased prescription opioid (PO) deaths are attributable to 5 other drugs.•Benzodiazepines and heroin contribute equally to increased PO…”
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A Molecular Basis for Nicotine as a Gateway Drug by Kandel, Eric R, Kandel, Denise B

“…Nearly all cocaine users are also smokers. Nicotine serves as a gateway drug to cocaine abuse. The Shattuck lecturers, Eric Kandel and Denise Kandel, reveal…”
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Comorbidity of Psychiatric Disorders and Nicotine Dependence Among Adolescents: Findings From a Prospective, Longitudinal Study by Griesler, Pamela C., Ph.D, Hu, Mei-Chen, Ph.D, Schaffran, Christine, M.A, Kandel, Denise B., Ph.D

“…Abstract Objective To examine prospectively the comorbidity of DSM-IV psychiatric disorders and nicotine dependence in adolescence. Method: A multiethnic…”
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A Molecular Basis for Nicotine as a Gateway Drug by Rosenberg, Jacob M, Kandel, Denise B, Kandel, Eric R

“…To the Editor: In their Shattuck Lecture (Sept. 4 issue), 1 Kandel and Kandel share evidence of a biochemical basis by which the use of nicotine enhances the…”
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Medical Use and Misuse of Prescription Opioids in the US Adult Population: 2016-2017 by Griesler, Pamela C, Hu, Mei-Chen, Wall, Melanie M, Kandel, Denise B

“…To characterize prescription opioid medical users and misusers among US adults. We used the 2016-2017 National Surveys on Drug Use and Health to compare…”
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Nonmedical Prescription Opioid Use by Parents and Adolescents in the US by Griesler, Pamela C, Hu, Mei-Chen, Wall, Melanie M, Kandel, Denise B

“…To date, intergenerational patterns of nonmedical prescription opioid (NMPO) use have not been examined. We investigate the association between parental and…”
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Birth Cohorts Analysis of Adolescent Cigarette Smoking and Subsequent Marijuana and Cocaine Use by Keyes, Katherine M, Hamilton, Ava, Kandel, Denise B

“…To examine whether the drug behavior of adults from different birth cohorts is shaped by adolescent drug experiences and whether adult prevalence of marijuana…”
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Nonmedical prescription opioids and pathways of drug involvement in the US: Generational differences by Wall, Melanie, Cheslack-Postava, Keely, Hu, Mei-Chen, Feng, Tianshu, Griesler, Pamela, Kandel, Denise B.

“…•NMPO fit within a developmental sequence of drug initiation.•NMPO or cocaine after marijuana, heroin after NMPO or cocaine, differ by generation.•The highest…”
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Molecular mechanism for a gateway drug: epigenetic changes initiated by nicotine prime gene expression by cocaine by Levine, Amir, Huang, Yanyou, Drisaldi, Bettina, Griffin, Jr, Edmund A, Pollak, Daniela D, Xu, Shiqin, Yin, Deqi, Schaffran, Christine, Kandel, Denise B, Kandel, Eric R

“…In human populations, cigarettes and alcohol generally serve as gateway drugs, which people use first before progressing to marijuana, cocaine, or other…”
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Social isolation is closely linked to a marked reduction in physical activity in male mice by Clemenza, Kelly, Weiss, Shira H., Cheslack, Keely, Kandel, Denise B., Kandel, Eric R., Levine, Amir A.

“…The effects of social isolation on an individual's behavior is an important field of research, especially as public health officials encourage social…”
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Age-related patterns in nonmedical prescription opioid use and disorder in the us population at ages 12-34 from 2002 to 2014 by Hu, Mei-Chen, Griesler, Pamela, Wall, Melanie, B.Kandel, Denise

“…Highlights • An age-period-cohort analysis spanning ages 12-34 was implemented. • Across birth cohorts, nonmedical prescription opioid use peaked at ages…”
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On the development of nicotine dependence in adolescence by Kandel, Denise B, Hu, Mei-Chen, Griesler, Pamela C, Schaffran, Christine

“…Abstract Little is known about the natural history of drug dependence. This article describes the development and predictors of DSM-IV nicotine dependence in…”
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Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine by Scherma, Maria, Qvist, Johanna S., Asok, Arun, Huang, Shao-shan C., Masia, Paolo, Deidda, Matteo, Wei, Ya B., Soni, Rajesh K., Fratta, Walter, Fadda, Paola, Kandel, Eric R., Kandel, Denise B., Melas, Philippe A.

“…The initial response to an addictive substance can facilitate repeated use: That is, individuals experiencing more positive effects are more likely to use that…”
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