Search Results - "Kandel, Benjamin A"

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  1. 1

    Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα) by Thomas, Maria, Burk, Oliver, Klumpp, Britta, Kandel, Benjamin A, Damm, Georg, Weiss, Thomas S, Klein, Kathrin, Schwab, Matthias, Zanger, Ulrich M

    Published in Molecular pharmacology (01-03-2013)
    “…The nuclear receptor peroxisome proliferator-activated receptor (PPAR)α is known primarily as a regulator of fatty acid metabolism, energy balance, and…”
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  2. 2

    Targeting Nuclear Receptors with Lentivirus-Delivered Small RNAs in Primary Human Hepatocytes by Thomas, Maria, Rieger, Jessica K., Kandel, Benjamin A., Klein, Kathrin, Zanger, Ulrich M.

    Published in Cellular physiology and biochemistry (01-01-2014)
    “…Background: RNA interference (RNAi) has tremendous potential for investigating gene function and for developing new therapies. Primary human hepatocytes (PHH)…”
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  3. 3

    Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes by Kandel, Benjamin A., Thomas, Maria, Winter, Stefan, Damm, Georg, Seehofer, Daniel, Burk, Oliver, Schwab, Matthias, Zanger, Ulrich M.

    Published in Biochimica et biophysica acta (01-09-2016)
    “…The ligand-activated nuclear receptor pregnane X receptor (PXR, NR1I2) and the constitutive androstane receptor (CAR, NR1I3) are two master transcriptional…”
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  4. 4

    Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms by Bitter, Andreas, Rümmele, Petra, Klein, Kathrin, Kandel, Benjamin A., Rieger, Jessica K., Nüssler, Andreas K., Zanger, Ulrich M., Trauner, Michael, Schwab, Matthias, Burk, Oliver

    Published in Archives of toxicology (01-11-2015)
    “…In addition to its well-characterized role in the regulation of drug metabolism and transport by xenobiotics, pregnane X receptor (PXR) critically impacts on…”
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  5. 5

    Virtual pathway explorer (viPEr) and pathway enrichment analysis tool (PEANuT): creating and analyzing focus networks to identify cross-talk between molecules and pathways by Garmhausen, Marius, Hofmann, Falko, Senderov, Viktor, Thomas, Maria, Kandel, Benjamin A, Habermann, Bianca Hermine

    Published in BMC genomics (14-10-2015)
    “…Interpreting large-scale studies from microarrays or next-generation sequencing for further experimental testing remains one of the major challenges in…”
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  6. 6

    No activation of human pregnane X receptor by hyperforin-related phloroglucinols by Kandel, Benjamin A, Ekins, Sean, Leuner, Kristina, Thasler, Wolfgang E, Harteneck, Christian, Zanger, Ulrich M

    “…The acylated phloroglucinol, hyperforin, the main active ingredient of St. John's Wort, exerts antidepressant properties via indirect inhibition of serotonin…”
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  7. 7

    systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana by Nägele, Thomas, Kandel, Benjamin A, Frana, Sabine, Meißner, Meike, Heyer, Arnd G

    Published in The FEBS journal (01-02-2011)
    “…Low temperature is an important environmental factor affecting the performance and distribution of plants. During the so-called process of cold acclimation,…”
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  8. 8

    Virtual pathway explorer : creating and analyzing focus networks to identify cross-talk between molecules and pathways by Garmhausen, Marius, Hofmann, Falko, Senderov, Viktor, Thomas, Maria, Kandel, Benjamin A, Habermann, Bianca Hermine

    Published in BMC genomics (14-10-2015)
    “…Interpreting large-scale studies from microarrays or next-generation sequencing for further experimental testing remains one of the major challenges in…”
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    Journal Article
  9. 9

    A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsisthaliana by Nägele, Thomas, Kandel, Benjamin A, Frana, Sabine, Meißner, Meike, Heyer, Arnd G

    Published in The FEBS journal (01-02-2011)
    “…Low temperature is an important environmental factor affecting the performance and distribution of plants. During the so-called process of cold acclimation,…”
    Get full text
    Journal Article