Search Results - "Kandel, Benjamin A"
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Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα)
Published in Molecular pharmacology (01-03-2013)“…The nuclear receptor peroxisome proliferator-activated receptor (PPAR)α is known primarily as a regulator of fatty acid metabolism, energy balance, and…”
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Targeting Nuclear Receptors with Lentivirus-Delivered Small RNAs in Primary Human Hepatocytes
Published in Cellular physiology and biochemistry (01-01-2014)“…Background: RNA interference (RNAi) has tremendous potential for investigating gene function and for developing new therapies. Primary human hepatocytes (PHH)…”
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Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes
Published in Biochimica et biophysica acta (01-09-2016)“…The ligand-activated nuclear receptor pregnane X receptor (PXR, NR1I2) and the constitutive androstane receptor (CAR, NR1I3) are two master transcriptional…”
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Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms
Published in Archives of toxicology (01-11-2015)“…In addition to its well-characterized role in the regulation of drug metabolism and transport by xenobiotics, pregnane X receptor (PXR) critically impacts on…”
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Virtual pathway explorer (viPEr) and pathway enrichment analysis tool (PEANuT): creating and analyzing focus networks to identify cross-talk between molecules and pathways
Published in BMC genomics (14-10-2015)“…Interpreting large-scale studies from microarrays or next-generation sequencing for further experimental testing remains one of the major challenges in…”
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No activation of human pregnane X receptor by hyperforin-related phloroglucinols
Published in The Journal of pharmacology and experimental therapeutics (01-03-2014)“…The acylated phloroglucinol, hyperforin, the main active ingredient of St. John's Wort, exerts antidepressant properties via indirect inhibition of serotonin…”
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systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana
Published in The FEBS journal (01-02-2011)“…Low temperature is an important environmental factor affecting the performance and distribution of plants. During the so-called process of cold acclimation,…”
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Virtual pathway explorer : creating and analyzing focus networks to identify cross-talk between molecules and pathways
Published in BMC genomics (14-10-2015)“…Interpreting large-scale studies from microarrays or next-generation sequencing for further experimental testing remains one of the major challenges in…”
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Journal Article -
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A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsisthaliana
Published in The FEBS journal (01-02-2011)“…Low temperature is an important environmental factor affecting the performance and distribution of plants. During the so-called process of cold acclimation,…”
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