Search Results - "Kandasamy, Mahesh"

NF-κB signalling as a pharmacological target in COVID-19: potential roles for IKKβ inhibitors by Kandasamy, Mahesh

“…Coronavirus disease 2019 (COVID-19) has been characterized by lymphopenia as well as a proinflammatory cytokine storm, which are responsible for the poor…”
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Perspectives for the use of therapeutic Botulinum toxin as a multifaceted candidate drug to attenuate COVID-19 by Kandasamy, Mahesh

“…The recent outbreak of coronavirus disease (COVID-19) resulting from a distinctive severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to…”
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Reactive Neuroblastosis in Huntington's Disease: A Putative Therapeutic Target for Striatal Regeneration in the Adult Brain by Kandasamy, Mahesh, Aigner, Ludwig

“…The cellular and molecular mechanisms underlying the reciprocal relationship between adult neurogenesis, cognitive and motor functions have been an important…”
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Neuroplasticity, limbic neuroblastosis and neuro-regenerative disorders by Kandasamy, Mahesh, Aigner, Ludwig

“…The brain is a dynamic organ of the biological renaissance due to the existence of neuroplasticity. Adult neurogenesis abides by every aspect of…”
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Liposome encapsulated clodronate mediated elimination of pathogenic macrophages and microglia: A promising pharmacological regime to defuse cytokine storm in COVID-19 by Ravichandran, Sowbarnika, Manickam, Nivethitha, Kandasamy, Mahesh

“…•COVID-19 has been characterized by macrophage activation syndrome and cytokine storm.•Clodronate, a bisphosphonate drug appears to deplete activated…”
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Intramuscular Injection of BOTOX® Boosts Learning and Memory in Adult Mice in Association with Enriched Circulation of Platelets and Enhanced Density of Pyramidal Neurons in the Hippocampus by Yesudhas, Ajisha, Roshan, Syed Aasish, Radhakrishnan, Risna Kanjirassery, Abirami, G. P. Poornimai, Manickam, Nivethitha, Selvaraj, Kaviya, Elumalai, Gokul, Shanmugaapriya, Sellathamby, Anusuyadevi, Muthuswamy, Kandasamy, Mahesh

“…BOTOX® is a therapeutic form of botulinum neurotoxin. It acts by blocking the release of acetylcholine (ACh) from the synaptic vesicles at the neuromuscular…”
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Cysteamine HCl Administration Impedes Motor and Olfactory Functions, Accompanied by a Reduced Number of Dopaminergic Neurons, in Experimental Mice: A Preclinical Mimetic Relevant to Parkinson's Disease by Selvaraj, Divya Bharathi, Panneerselvam, Anusiya, Vergil Andrews, Jemi Feiona, Kandasamy, Mahesh

“…Cysteamine hydrochloride (Cys-HCl) has been established as a potent ulcerogenic agent of the gastrointestinal (GI) system. GI dysfunction and olfactory…”
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Low-dose aspirin increases olfactory sensitivity in association with enhanced neurogenesis and reduced activity of AChE in the experimental aging mice by Vergil Andrews, Jemi Feiona, Selvaraj, Divya Bharathi, Bhavani Radhakrishnan, Abhinav, Kandasamy, Mahesh

“…•This study investigated the effect of aspirin on the regulation of olfactory functions and neurogenesis in experimental aging mice.•Aspirin-treated animals…”
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Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice by Radhakrishnan, Risna Kanjirassery, Ravichandran, Sowbarnika, Sukesh, Aishwarya, Kadalmani, Balamuthu, Kandasamy, Mahesh

“…Botulinum toxin (BoNT) is a widely used therapeutic agent that blocks the excessive release of acetylcholine at the neuromuscular junction. Previously,…”
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Ranitidine Alleviates Anxiety-like Behaviors and Improves the Density of Pyramidal Neurons upon Deactivation of Microglia in the CA3 Region of the Hippocampus in a Cysteamine HCl-Induced Mouse Model of Gastrointestinal Disorder by Selvaraj, Divya Bharathi, Vergil Andrews, Jemi Feiona, Anusuyadevi, Muthuswamy, Kandasamy, Mahesh

“…Elevated levels of histamine cause over-secretion of gastric hydrochloric acid (HCl), leading to gastrointestinal (GI) disorders and anxiety. Ranitidine is an…”
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Prolactin Prevents Chronic Stress-Induced Decrease of Adult Hippocampal Neurogenesis and Promotes Neuronal Fate by Torner, Luz, Karg, Sandra, Blume, Annegret, Kandasamy, Mahesh, Kuhn, Hans-Georg, Winkler, Jurgen, Aigner, Ludwig, Neumann, Inga D

“…Chronic exposure to stress results in a reduction of hippocampal neurogenesis and of hippocampal volume. We examined whether prolactin (PRL), a regulator of…”
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Reduction in subventricular zone-derived olfactory bulb neurogenesis in a rat model of Huntington's disease is accompanied by striatal invasion of neuroblasts by Kandasamy, Mahesh, Rosskopf, Michael, Wagner, Katrin, Klein, Barbara, Couillard-Despres, Sebastien, Reitsamer, Herbert A, Stephan, Michael, Nguyen, Huu Phuc, Riess, Olaf, Bogdahn, Ulrich, Winkler, Jürgen, von Hörsten, Stephan, Aigner, Ludwig

“…Huntington's disease (HD) is an inherited progressive neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the huntingtin gene (HTT). The…”
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A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice by Vergil Andrews, Jemi Feiona, Selvaraj, Divya Bharathi, Kumar, Akshay, Roshan, Syed Aasish, Anusuyadevi, Muthuswamy, Kandasamy, Mahesh

“…Aspirin has been reported to prevent memory decline in the elderly population. Adult neurogenesis in the hippocampus has been recognized as an underlying basis…”
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In vitro transdifferentiation of human adipose tissue-derived stem cells to neural lineage cells - a stage-specific incidence by Radhakrishnan, Subathra, Trentz, Omana Anna, Reddy, Mettu Srinivas, Rela, Mohamed, Kandasamy, Mahesh, Sellathamby, Shanmugaapriya

“…The present Study investigated the intrinsic ability of adipose tissue-derived stem cells (ADSCs) and their neural transdifferentiation in a stage-specific…”
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Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease by Kohl, Zacharias, Regensburger, Martin, Aigner, Robert, Kandasamy, Mahesh, Winner, Beate, Aigner, Ludwig, Winkler, Jürgen

“…Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder linked to expanded CAG-triplet nucleotide repeats within the huntingtin gene…”
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Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder by Sri Rethinavel, Harini, Selvaraj, Divya Bharathi, Balakrishnan, Sathya Jeevitha, Vergil Andrews, Jemi Feiona, Joseph, Jerly Helan Mary, Kandasamy, Mahesh

“…Omeprazole, a proton pump inhibitor (PPI), has widely been used to treat various gastrointestinal (GI) disorders. Notably, many clinical symptoms of GI…”
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Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein by Marxreiter, Franz, Nuber, Silke, Kandasamy, Mahesh, Klucken, Jochen, Aigner, Robert, Burgmayer, Ralf, Couillard-Despres, Sebastien, Riess, Olaf, Winkler, Jürgen, Winner, Beate

“…In familial and sporadic forms of Parkinson’s disease (PD), alpha‐synuclein pathology is present in the brain stem nuclei and olfactory bulb (OB) long before…”
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Intertwining Neuropathogenic Impacts of Aberrant Circadian Rhythm and Impaired Neuroregenerative Plasticity in Huntington’s Disease: Neurotherapeutic Significance of Chemogenetics by Ravichandran, Sowbarnika, Suhasini, Ramalingam, Madheswaran Deepa, Sudhiksha, Selvaraj, Divya Bharathi, Vergil Andrews, Jemi Feiona, Thiagarajan, Viruthachalam, Kandasamy, Mahesh

“…Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by abnormal progressive involuntary movements, cognitive deficits, sleep…”
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Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington’s Disease by Bogdahn, Ulrich, Reilmann, Ralf, Winkler, Jürgen, Aigner, Ludwig, Kandasamy, Mahesh

“…The neural stem cell niches possess the regenerative capacity to generate new functional neurons in the adult brain, suggesting the possibility of endogenous…”
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COVID-19 and Parkinson’s disease: Defects in neurogenesis as the potential cause of olfactory system impairments and anosmia by Rethinavel, Harini Sri, Ravichandran, Sowbarnika, Radhakrishnan, Risna Kanjirassery, Kandasamy, Mahesh

“…[Display omitted] •COVID-19 has been characterized by the degeneration of sensory neurons and dopaminergic neurons in the olfactory system.•SARS CoV-2…”
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