Search Results - "Kandabashi, T"

Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension by Mukai, Y, Shimokawa, H, Matoba, T, Kandabashi, T, Satoh, S, Hiroki, J, Kaibuchi, K, Takeshita, A

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Different Vasculoprotective Roles of NO Synthase Isoforms in Vascular Lesion Formation in Mice by Yogo, Kenji, Shimokawa, Hiroaki, Funakoshi, Hajime, Kandabashi, Tadashi, Miyata, Kenji, Okamoto, Shinichiro, Egashira, Kensuke, Huang, Paul, Akaike, Takaaki, Takeshita, Akira

“…NO is known to have several important vasculoprotective actions. Although NO is synthesized by 3 different NO synthase (NOS) isoforms, the vasculoprotective…”
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Hemidiaphragmatic paralysis following subclavian vein catheterization by AKATA, T., NODA, Y., NAGATA, T., NODA, E., KANDABASHI, T.

“…The right subclavian artery was inadvertently punctured during attempted preoperative insertion of a right subclavian venous catheter in a 59‐yr‐old woman…”
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Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells by Hiroki, Junko, Shimokawa, Hiroaki, Higashi, Midoriko, Morikawa, Keiko, Kandabashi, Tadashi, Kawamura, Natsumi, Kubota, Toru, Ichiki, Toshihiro, Amano, Mutsuki, Kaibuchi, Kozo, Takeshita, Akira

“…Recent studies have demonstrated that upregulated Rho-kinase plays an important role in the pathogenesis of arteriosclerosis and vasospasm in both animals and…”
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Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm by SHIMOKAWA, H, SETO, M, ASANO, T, KAIBUCHI, K, TAKESHITA, A, KATSUMATA, N, AMANO, M, KOZAI, T, YAMAWAKI, T, KUWATA, K, KANDABASHI, T, EGASHIRA, K, IKEGAKI, I

“…We recently demonstrated in our swine model of coronary artery spasm that enhanced myosin light chain (MLC) phosphorylations (both MLC mono- and…”
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Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β by KANDABASHI, T, SHIMOKAWA, H, TAKESHITA, A, MIYATA, K, KUNIHIRO, I, KAWANO, Y, FUKATA, Y, HIGO, T, EGASHIRA, K, TAKAHASHI, S, KAIBUCHI, K

“…Background —We recently demonstrated that the Rho-kinase–mediated pathway plays an important role for coronary artery spasm in our porcine model with…”
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Rho-Kinase Is Involved in Macrophage-Mediated Formation of Coronary Vascular Lesions in Pigs In Vivo by Miyata, Kenji, Shimokawa, Hiroaki, Kandabashi, Tadashi, Higo, Taiki, Morishige, Kunio, Eto, Yasuhiro, Egashira, Kensuke, Kaibuchi, Kozo, Takeshita, Akira

“…We have previously shown that long-term treatment with an inflammatory cytokine from the adventitia causes the development of coronary vascular lesions, with…”
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Evidence for Protein Kinase C-Mediated Activation of Rho- Kinase in a Porcine Model of Coronary Artery Spasm by Kandabashi, Tadashi, Shimokawa, Hiroaki, Miyata, Kenji, Kunihiro, Ikuko, Eto, Yasuhiro, Morishige, Kunio, Matsumoto, Yasuharu, Obara, Kazuo, Nakayama, Koichi, Takahashi, Shosuke, Takeshita, Akira

“…OBJECTIVE—We have recently demonstrated that protein kinase C (PKC) and Rho-kinase play important roles in coronary vasospasm in a porcine model. However, it…”
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Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo by SHIMOKAWA, Hiroaki, MORISHIGE, Kunio, MIYATA, Kenji, KANDABASHI, Tadashi, ETO, Yasuhiro, IKEGAKI, Ichiro, ASANO, Toshio, KAIBUCHI, Kozo, TAKESHITA, Akira

“…We recently demonstrated that Rho-kinase/ROK/ROCK is functionally upregulated at the arteriosclerotic coronary lesions and plays a key role for coronary…”
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Involvement of Rho-Kinase in Agonists-Induced Contractions of Arteriosclerotic Human Arteries by Kandabashi, Tadashi, Shimokawa, Hiroaki, Mukai, Yasushi, Matoba, Tetsuya, Kunihiro, Ikuko, Morikawa, Keiko, Ito, Masaaki, Takahashi, Shosuke, Kaibuchi, Kozo, Takeshita, Akira

“…Coronary artery spasm plays an important role in the pathogenesis of a wide variety of ischemic heart diseases. We have recently demonstrated that Rho-kinase…”
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Adenovirus-Mediated Transfer of Dominant-Negative Rho-Kinase Induces a Regression of Coronary Arteriosclerosis in Pigs In Vivo by Morishige, Kunio, Shimokawa, Hiroaki, Eto, Yasuhiro, Kandabashi, Tadashi, Miyata, Kenji, Matsumoto, Yasuharu, Hoshijima, Masahiko, Kaibuchi, Kozo, Takeshita, Akira

“…ABSTRACT—Small GTPase Rho and its target Rho-kinase/ROK/ROCK play an important role in various cellular functions, including smooth muscle contraction, actin…”
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Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs by Eto, Y, Shimokawa, H, Hiroki, J, Morishige, K, Kandabashi, T, Matsumoto, Y, Amano, M, Hoshijima, M, Kaibuchi, K, Takeshita, A

“…Restenosis after angioplasty still remains a major problem for which neointimal formation appears to play an important role. Recent studies in vitro suggested…”
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Local adenovirus-mediated transfer of C-type natriuretic peptide suppresses vascular remodeling in porcine coronary arteries in vivo by Morishige, Kunio, Shimokawa, Hiroaki, Yamawaki, Tohru, Miyata, Kenji, Eto, Yasuhiro, Kandabashi, Tadashi, Yogo, Kenji, Higo, Taiki, Egashira, Kensuke, Ueno, Hikaru, Takeshita, Akira

“…OBJECTIVE This study was designed to examine whether or not adenovirus-mediated gene transfer of C-type natriuretic peptide (CNP) can prevent coronary…”
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Combination Therapy with Cerivastatin and Nifedipine Improves Endothelial Dysfunction After Balloon Injury in Porcine Coronary Arteries by Eto, Yasuhiro, Shimokawa, Hiroaki, Fukumoto, Yoshihiro, Matsumoto, Yasuharu, Morishige, Kunio, Kunihiro, Ikuko, Kandabashi, Tadashi, Takeshita, Akira

“…HMG-CoA reductase inhibitors and calcium channel blockers have antiatherogenic effects; however, their mechanisms remain to be elucidated. This study examined…”
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Sarpogrelate, a Selective 5-HT2A Serotonergic Receptor Antagonist, Inhibits Serotonin-Induced Coronary Artery Spasm in a Porcine Model by Miyata, Kenji, Shimokawa, Hiroaki, Higo, Taiki, Yamawaki, Tohru, Katsumata, Naoki, Kandabashi, Tadashi, Tanaka, Eriko, Takamura, Yoshiaki, Yogo, Kenji, Egashira, Kensuke, Takeshita, Akira

“…Serotonin is one of the most important vasoactive substances and has been implicated in the pathogenesis of coronary artery spasm and of acute coronary…”
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Propagermanium Suppresses Macrophage-Mediated Formation of Coronary Arteriosclerotic Lesions in Pigs in Vivo by Shimokawa, Hiroaki, Eto, Yasuhiro, Miyata, Kenji, Morishige, Kunio, Kandabashi, Tadashi, Matsushima, Kouji, Takeshita, Akira

“…Although the importance of monocytes/macrophages in the pathogenesis of arteriosclerosis is widely accepted, effective and safe treatment to inhibit those…”
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A56 COMBINED USE OF TRANSESOPHAGEAL ECHOCARDIOGRAPHY AND TONOMETRY ENABLES TO ASSESS END-SYSTOLIC PRESSURE-AREA RELATIONSHIP DURING ABDOMINAL AORTIC SURGERY by Yamaura, K., Hoka, S., Kandabashi, T., Taniyama, T., Takahashi, S.

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Massive retroperitoneal hemorrhage associated with femoral vein cannulation by Akata, Takashi, Nakayama, Tetsuzo, Kandabashi, Tadashi, Kodama, Kenji, Takahashi, Shosuke

“…The right external iliac artery was inadvertently punctured during attempted right femoral vein catheterization. Severe hypotension developed several minutes…”
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Changes in left ventricular end-diastolic area, end-systolic wall stress, and fractional area change during anesthetic induction with propofol or thiamylal by Yamaura, K, Hoka, S, Okamoto, H, Kandabashi, T, Akiyoshi, K, Takahashi, S

“…To elucidate the mechanisms of the more profound hypotensive effects of propofol relative to thiamylal, we monitored changes in left ventricular (LV) preload,…”
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Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta by Kandabashi, T, Shimokawa, H, Miyata, K, Kunihiro, I, Kawano, Y, Fukata, Y, Higo, T, Egashira, K, Takahashi, S, Kaibuchi, K, Takeshita, A

“…We recently demonstrated that the Rho-kinase-mediated pathway plays an important role for coronary artery spasm in our porcine model with interleukin-1beta…”
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