Search Results - "Kanda, Kevin"

Investigating the Mechanism of SF3B1 Promoted BRCA1 Dependent Homologous Recombination by Kanda, Kevin Farol

“…Mutations in many splice factors result in faulty mRNA transcripts that lead to the production of defective proteins and is a hallmark of cancer (Zhang et al.,…”
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Abstract 584: Conquering undruggable oncogenic K-RAS-driven incurable metastatic cancer, and delivering precision medicine at neoadjuvant settings by Tang, Amy H., Sciver, Robert E. Van, Svyatova, Elizaveta, Kanda, Kevin, Lee, Michael P., Lee, Caroline Dasom, Reesema, Lauren L. Siewertsz Van, Lafever, Alex C., Collier, Amber L., Iyer, Apoorva S., Britt, L.D., Winston, Janet S., Allen, Cynthia A., Chang, David Z., Petersen, Gloria M., Hoefer, Richard A.

“…SIAH is a new and potent anti-K-RAS drug target in human cancer. The oncogenic EGFR/HER2/K-RAS pathway activation is pivotal in driving uncontrolled tumor…”
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A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology by Van Sciver, Robert E, Lee, Michael P, Lee, Caroline Dasom, Lafever, Alex C, Svyatova, Elizaveta, Kanda, Kevin, Colliver, Amber L, Siewertsz van Reesema, Lauren L, Tang-Tan, Angela M, Zheleva, Vasilena, Bwayi, Monicah N, Bian, Minglei, Schmidt, Rebecca L, Matrisian, Lynn M, Petersen, Gloria M, Tang, Amy H

“…Oncogenic K-RAS mutations are found in virtually all pancreatic cancers, making K-RAS one of the most targeted oncoproteins for drug development in cancer…”
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