Search Results - "Kanda, Keitaro"

The role of CXCR3 and CXCR4 in colorectal cancer metastasis by Murakami, Teppei, Kawada, Kenji, Iwamoto, Masayoshi, Akagami, Masatoshi, Hida, Koya, Nakanishi, Yuki, Kanda, Keitaro, Kawada, Mayumi, Seno, Hiroshi, Taketo, Makoto Mark, Sakai, Yoshiharu

“…Chemokines and their receptors play key roles in leukocyte trafficking and are also implicated in cancer metastasis. We previously demonstrated that forced…”
Get full text

Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice by Ikuta, Kozo, Fukuda, Akihisa, Ogawa, Satoshi, Masuo, Kenji, Goto, Norihiro, Hiramatsu, Yukiko, Tsuda, Motoyuki, Kimura, Yoshito, Matsumoto, Yoshihide, Kimura, Yuto, Maruno, Takahisa, Kanda, Keitaro, Nishi, Kiyoto, Takaori, Kyoichi, Uemoto, Shinji, Takaishi, Shigeo, Chiba, Tsutomu, Nishi, Eiichiro, Seno, Hiroshi

“…Nardilysin (NRDC), a zinc peptidase, exhibits multiple localisation-dependent functions including as an enhancer of ectodomain shedding in the extracellular…”
Get more information

Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes by Ishizu-Higashi, Shoko, Seno, Hiroshi, Nishi, Eiichiro, Matsumoto, Yoshihide, Ikuta, Kozo, Tsuda, Motoyuki, Kimura, Yoshito, Takada, Yutaka, Kimura, Yuto, Nakanishi, Yuki, Kanda, Keitaro, Komekado, Hideyuki, Chiba, Tsutomu

“…Nonalcoholic steatohepatitis (NASH) is an inflammatory form of nonalcoholic fatty liver disease that progresses to liver cirrhosis. It is still unknown how…”
Get full text

Conversion from Latent to Symptomatic Sheehan's Syndrome by Pegylated Interferon Therapy for Chronic Hepatitis C by Kanda, Keitaro, Kayahara, Takahisa, Seno, Hiroshi, Yamashita, Yukitaka, Chiba, Tsutomu

“…A 58-year-old woman with chronic hepatitis C was admitted to our hospital to receive interferon (IFN) therapy. Twenty years earlier she had received blood…”
Get full text

Dclk1 distinguishes between tumor and normal stem cells in the intestine by Nakanishi, Yuki, Seno, Hiroshi, Fukuoka, Ayumi, Ueo, Taro, Yamaga, Yuichi, Maruno, Takahisa, Nakanishi, Naoko, Kanda, Keitaro, Komekado, Hideyuki, Kawada, Mayumi, Isomura, Akihiro, Kawada, Kenji, Sakai, Yoshiharu, Yanagita, Motoko, Kageyama, Ryoichiro, Kawaguchi, Yoshiya, Taketo, Makoto M, Yonehara, Shin, Chiba, Tsutomu

“…Hiroshi Seno and colleagues report that Dclk1 selectively marks intestinal tumor stem cells. They further show that specific ablation of these cells in a mouse…”
Get full text

Inhibitory role of Gas6 in intestinal tumorigenesis by Akitake-Kawano, Reiko, Seno, Hiroshi, Nakatsuji, Masato, Kimura, Yuto, Nakanishi, Yuki, Yoshioka, Takuto, Kanda, Keitaro, Kawada, Mayumi, Kawada, Kenji, Sakai, Yoshiharu, Chiba, Tsutomu

“…Growth arrest-specific gene (Gas) 6 is a γ-carboxyglutamic acid domain-containing protein, which shares 43% amino acid identity with protein S. Gas6 has been…”
Get full text

952 Nardilysin Maintains Gastric Cancer Cell Growth via Promoting Shedding of TNF-α and Intrinsic Cytokine Signaling by Kanda, Keitaro, Komekado, Hideyuki, Seno, Hiroshi, Chiba, Tsutomu

Get full text

Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer by Kawada, M, Seno, H, Kanda, K, Nakanishi, Y, Akitake, R, Komekado, H, Kawada, K, Sakai, Y, Mizoguchi, E, Chiba, T

“…Chitinase 3-like 1 (CHI3L1), one of the mammalian members of the chitinase family, is expressed in several types of human cancer, and elevated serum level of…”
Get full text

Simulation Study of Low-Dose Sparse-Sampling CT with Deep Learning-Based Reconstruction: Usefulness for Evaluation of Ovarian Cancer Metastasis by Urase, Yasuyo, Nishio, Mizuho, Ueno, Yoshiko, Kono, Atsushi K, Kanda, Keitaro Sofue Tomonori, Maeda, Takaki, Nogami, Munenobu, Hori, Masatoshi, Murakami, Takamichi

“…The usefulness of sparse-sampling CT with deep learning-based reconstruction for detection of metastasis of malignant ovarian tumors was evaluated. We obtained…”
Get full text

Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF‐α by Kanda, Keitaro, Komekado, Hideyuki, Sawabu, Tateo, Ishizu, Shoko, Nakanishi, Yuki, Nakatsuji, Masato, Akitake‐Kawano, Reiko, Ohno, Mikiko, Hiraoka, Yoshinori, Kawada, Mayumi, Kawada, Kenji, Sakai, Yoshiharu, Matsumoto, Kyoichi, Kunichika, Makoto, Kimura, Takeshi, Seno, Hiroshi, Nishi, Eiichiro, Chiba, Tsutomu

“…Nardilysin (NRDc), a metalloendopeptidase of the M16 family, promotes ectodomain shedding of the precursor forms of various growth factors and cytokines by…”
Get full text

Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation by Kanda, Keitaro, Sakamoto, Jiro, Matsumoto, Yoshihide, Ikuta, Kozo, Goto, Norihiro, Morita, Yusuke, Ohno, Mikiko, Nishi, Kiyoto, Eto, Koji, Kimura, Yuto, Nakanishi, Yuki, Ikegami, Kanako, Yoshikawa, Takaaki, Fukuda, Akihisa, Kawada, Kenji, Sakai, Yoshiharu, Ito, Akihiro, Yoshida, Minoru, Kimura, Takeshi, Chiba, Tsutomu, Nishi, Eiichiro, Seno, Hiroshi

“…Colon cancer is a complex disease affected by a combination of genetic and epigenetic factors. Here we demonstrate that nardilysin (N-arginine dibasic…”
Get full text

COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps by NAKANISHI, Yuki, NAKATSUJI, Masato, CHIBA, Tsutomu, SENO, Hiroshi, ISHIZU, Shoko, AKITAKE-KAWANO, Reiko, KANDA, Keitaro, UEO, Taro, KOMEKADO, Hideyuki, KAWADA, Mayumi, MINAMI, Manabu

“…Macrophages are a major component of tumor stroma. Tumor-associated macrophages (TAMs) show anti- (M1) or protumor (M2) functions depending on the cytokine…”
Get full text