EXPERIMENTAL AND CLINICAL STUDY FOR BIDIRECTIONAL PERITONEAL DIALYSIS (BPD)
BPD was introduced to enhance solute removal efficiency in conventional PD therapies such as CAPD. In the BPD, we insert a conventional PD catheter into intraperitoneal space, through which a certain amount of peritoneal dialysate is introduced. With a reversible pump, a preset volume of the periton...
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| Published in: | ASAIO journal (1992) Vol. 46; no. 2; p. 213 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-04-2000
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | BPD was introduced to enhance solute removal efficiency in conventional PD therapies such as CAPD. In the BPD, we insert a conventional PD catheter into intraperitoneal space, through which a certain amount of peritoneal dialysate is introduced. With a reversible pump, a preset volume of the peritoneal dialysate reciprocates between the peritoneal cavity and a dialysate reservoir, giving the system a drain phase and an infusion phase alternatively. In the drain phase, a part of the dwelt dialysate is drained through the PD catheter at 100 ml/min (Q sub(DR)) and enters the reservoir. In the infusion phase, the dialysate in the reservoir is returned to the peritoneal cavity at 300 ml/min (Q sub(IN)). In both phases, the add-on dialyzer purifies the peritoneal dialysate continually. The dialysate flow rate (Q sub(D)) from the machine was 100 ml/min. In this study, solute removal characteristics of BPD were examined in a canine and a clinical study. Solute reduction rate in BPD with a dialysate reservoir volume (V sub(R)) of 200 ml, 350 ml, 500 ml was compared with that in conventional PD (CPD, 120 min dwelling x 2) and tidal PD (TPD, 20 min dwelling x 12, 50% of tidal volume ratio) over the same period of time (240 min). The urea reduction rate in BPD, CPD and TPD were 20.0 plus or minus 7.2% (n identical with 16), 3.5 plus or minus 3.6% (n identical with 7), and 17.3 plus or minus 4.7% (n identical with 6), respectively. The creatinine reduction rate in BPD, IPD and TPD were 21.0 plus or minus 7.0% (n identical with 16), 2.1 plus or minus 4.1% (n identical with 7), and 17.2 plus or minus 6.2% (n identical with 6). In the clinical study, BPD and CPD (180 min x 2) treatments were applied to 7 renal failure patients. Higher solute removal efficiency was shown in a BPD than in CPD treatments. The urea reduction rate was obtained as 9.7 plus or minus 6.4% (n identical with 8) in BPD, shigher (P<0.01) than the 1.0 plus or minus 2.8 5 in CPD (n identical with 10). |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-2 ObjectType-Feature-1 content type line 23 SourceType-Conference Papers & Proceedings-1 ObjectType-Conference-3 |
| ISSN: | 1058-2916 |
| DOI: | 10.1097/00002480-200003000-00251 |