Search Results - "Kanazawa, Masakatsu"

Differences in in vitro microglial accumulation of the energy metabolism tracers [18F]FDG and [18F]BCPP-EF during LPS- and IL4 stimulation by Suzuki, Chie, Han, Sarina, Kesavamoorthy, Gandhervin, Kosugi, Mutsumi, Araki, Kaori, Harada, Norihiro, Kanazawa, Masakatsu, Tsukada, Hideo, Magata, Yasuhiro, Ouchi, Yasuomi

“…The positron emission tomography probes 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ 18 F]FDG) and 2- tert -butyl-4-chloro-5-{6-[2-(2-[ 18…”
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PET Imaging of Ischemia-Induced Impairment of Mitochondrial Complex I Function in Monkey Brain by Tsukada, Hideo, Ohba, Hiroyuki, Nishiyama, Shingo, Kanazawa, Masakatsu, Kakiuchi, Takeharu, Harada, Norihiro

“…To assess the capability of 18F-2-tert-butyl-4-chloro-5-{6-[2-(2-fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2H-pyridazin-3-one (18F-BCPP-EF), a novel positron…”
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Development of novel PET probes, [18F]BCPP-EF, [18F]BCPP-BF, and [11C]BCPP-EM for mitochondrial complex 1 imaging in the living brain by Harada, Norihiro, Nishiyama, Shingo, Kanazawa, Masakatsu, Tsukada, Hideo

“…We developed three novel positron‐emission tomography (PET) probes,…”
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In vivo alterations of mitochondrial activity and amyloidosis in early-stage senescence-accelerated mice: a positron emission tomography study by Yamagishi, Satoru, Iga, Yurika, Ikegaya, Shunsuke, Kakiuchi, Takeharu, Ohba, Hiroyuki, Nishiyama, Shingo, Fukomoto, Daisuke, Kanazawa, Masakatsu, Harada, Norihiro, Tsukada, Hideo, Sato, Kohji, Ouchi, Yasuomi

“…While marked reductions in neural activity and mitochondrial function have been reported in Alzheimer's disease (AD), the degree of mitochondrial activity in…”
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Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity by Hosoi, Rie, Fujii, Yuka, Hiroyuki, Ohba, Shukuri, Miho, Nishiyama, Shingo, Kanazawa, Masakatsu, Todoroki, Kenichiro, Arano, Yasushi, Sakai, Toshihiro, Tsukada, Hideo, Inoue, Osamu

“…Purpose Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative…”
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Synthesis of 6-[11C]methyl-m-tyrosine ([11C]6MemTyr) for dopamine synthesis imaging in living brain using PET by Kanazawa, Masakatsu, Ohba, Hiroyuki, Iwazaki, Aiko, Kakiuchi, Takeharu, Tsukada, Hideo

“…[Display omitted] A novel PET probe, 6-[11C]methyl-m-tyrosine ([11C]6MemTyr), was developed for quantitative imaging of presynaptic dopamine (DA) synthesis in…”
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Monitoring Mitochondrial Complex-I Activity Using Novel PET Probe 18F-BCPP-EF Allows Early Detection of Radiotherapy Effect in Murine Squamous Cell Carcinoma by Murayama, Chieko, Kawaguchi, Akira T, Kamijo, Akemi, Naito, Katsuko, Kanazawa, Masakatsu, Tsukada, Hideo

“…Aerobic glycolysis, the main pathway of energy production in tumors (Warburg effect) allows detection of tumors by positron emission tomography (PET) using…”
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Synthesis and evaluation of N-isopropyl-p-[11C]methylamphetamine as a novel cerebral blood flow tracer for positron emission tomography by Toyohara, Jun, Harada, Norihiro, Kakiuchi, Takeharu, Ohba, Hiroyuki, Kanazawa, Masakatsu, Tago, Tetsuro, Sakata, Muneyuki, Ishiwata, Kiichi

“…Introduction Increases in fasting plasma glucose (PG) levels lead to a decrease in 2-deoxy-2-[ 18 F]fluoro- d -glucose ([ 18 F]FDG) uptake in the normal brain,…”
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Evaluation of D-isomers of 4-borono-2-18F-fluoro-phenylalanine and O-11C-methyl-tyrosine as brain tumor imaging agents: a comparative PET study with their L-isomers in rat brain glioma by Kanazawa, Masakatsu, Nishiyama, Shingo, Hashimoto, Fumio, Kakiuchi, Takeharu, Tsukada, Hideo

“…Background The potential of the D-isomerization of 4-borono-2- 18 F-fluoro-phenylalanine ( 18 F-FBPA) to improve its target tumor to non-target normal brain…”
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Evaluation of 18F-BCPP-EF for mitochondrial complex 1 imaging in the brain of conscious monkeys using PET by Tsukada, Hideo, Ohba, Hiroyuki, Kanazawa, Masakatsu, Kakiuchi, Takeharu, Harada, Norihiro

“…Purpose We have reported on the development of a novel PET probe, 18 F-2- tert -butyl-4-chloro-5-{6-[2-(2-fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2 H…”
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Synthesis of an acromelic acid A analog-based 11C-labeled PET tracer for exploration of the site of action of acromelic acid A in allodynia induction by Kanazawa, Masakatsu, Furuta, Kyoji, Doi, Hisashi, Mori, Tomoko, Minami, Toshiaki, Ito, Seiji, Suzuki, Masaaki

“…A novel 11C-labeled PET (positron emission tomography) tracer, which was designed based on the (phenylthio)pyrrolidine derivative that can competitively block…”
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Preclinical validation of a novel brain-penetrant PET ligand for visualization of histone deacetylase 6: a potential imaging target for neurodegenerative diseases by Tago, Tetsuro, Sakata, Muneyuki, Kanazawa, Masakatsu, Yamamoto, Shigeyuki, Ishii, Kenji, Toyohara, Jun

“…Purpose Histone deacetylase 6 (HDAC6) has emerged as a therapeutic target for neurodegenerative diseases such as Alzheimer’s disease. Noninvasive imaging of…”
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Effect of MPTP on Serotonergic Neuronal Systems and Mitochondrial Complex I Activity in the Living Brain: A PET Study on Conscious Rhesus Monkeys by Kanazawa, Masakatsu, Ohba, Hiroyuki, Nishiyama, Shingo, Kakiuchi, Takeharu, Tsukada, Hideo

“…The objective of the present PET study was to compare the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on serotonergic neuronal systems and…”
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Synthesis of 11C‑Labeled Thiamine and Fursultiamine for in Vivo Molecular Imaging of Vitamin B1 and Its Prodrug Using Positron Emission Tomography by Doi, Hisashi, Mawatari, Aya, Kanazawa, Masakatsu, Nozaki, Satoshi, Nomura, Yukihiro, Kitayoshi, Takahito, Akimoto, Kouji, Suzuki, Masaaki, Ninomiya, Shinji, Watanabe, Yasuyoshi

“…To enable in vivo analysis of the kinetics of vitamin B1 (thiamine) and its derivatives by positron emission tomography (PET), 11C-labeled thiamine ([11C]-1)…”
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Biodistribution assessment of cationic pullulan nanogel, a nasal vaccine delivery system, in mice and non-human primates by Yuki, Yoshikazu, Harada, Norihiro, Sawada, Shin-ichi, Uchida, Yohei, Nakahashi-Ouchida, Rika, Mori, Hiromi, Yamanoue, Tomoyuki, Machita, Tomonori, Kanazawa, Masakatsu, Fukumoto, Dai, Ohba, Hiroyuki, Miyazaki, Takashi, Akiyoshi, Kazunari, Fujihashi, Kohtaro, Kiyono, Hiroshi

“…•cCHP nanogel is a safe vaccine delivery system for nasally administered compounds.•Radiolabeled cCHP-nanogel was used in traditional biodistribution assays of…”
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Comparing amyloid-β deposition, neuroinflammation, glucose metabolism, and mitochondrial complex I activity in brain: a PET study in aged monkeys by Tsukada, Hideo, Nishiyama, Shingo, Ohba, Hiroyuki, Kanazawa, Masakatsu, Kakiuchi, Takeharu, Harada, Norihiro

“…Purpose The aim of the present study was to compare amyloid-β (Aβ) deposition, translocator protein (TSPO) activity, regional cerebral metabolic rate of…”
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Comparing α7 nicotinic acetylcholine receptor binding, amyloid-β deposition, and mitochondria complex-I function in living brain: A PET study in aged monkeys by Nishiyama, Shingo, Ohba, Hiroyuki, Kanazawa, Masakatsu, Kakiuchi, Takeharu, Tsukada, Hideo

“…ABSTRACT This study was aimed to assess the correlations among α7 nicotinic acetylcholine receptor (α7‐nAChR) binding, amyloid‐β (Aβ) deposition, and…”
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Comparing [alpha]7 nicotinic acetylcholine receptor binding, amyloid-[beta] deposition, and mitochondria complex-I function in living brain: A PET study in aged monkeys by Nishiyama, Shingo, Ohba, Hiroyuki, Kanazawa, Masakatsu, Kakiuchi, Takeharu, Tsukada, Hideo

“…This study was aimed to assess the correlations among [alpha]7 nicotinic acetylcholine receptor ([alpha]7-nAChR) binding, amyloid-[beta] (A[beta]) deposition,…”
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Monitoring Mitochondrial Complex-I Activity Using Novel PET Probe .sup.18F-BCPP-EF Allows Early Detection of Radiotherapy Effect in Murine Squamous Cell Carcinoma by Murayama, Chieko, Kawaguchi, Akira T, Kamijo, Akemi, Naito, Katsuko, Kanazawa, Masakatsu, Tsukada, Hideo

“…Objectives Aerobic glycolysis, the main pathway of energy production in tumors (Warburg effect) allows detection of tumors by positron emission tomography…”
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Synthesis of (11)C-Labeled Thiamine and Fursultiamine for in Vivo Molecular Imaging of Vitamin B1 and Its Prodrug Using Positron Emission Tomography by Doi, Hisashi, Mawatari, Aya, Kanazawa, Masakatsu, Nozaki, Satoshi, Nomura, Yukihiro, Kitayoshi, Takahito, Akimoto, Kouji, Suzuki, Masaaki, Ninomiya, Shinji, Watanabe, Yasuyoshi

“…To enable in vivo analysis of the kinetics of vitamin B1 (thiamine) and its derivatives by positron emission tomography (PET), (11)C-labeled thiamine…”
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