Search Results - "Kananen, L"

Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study by Kananen, L, Marttila, S, Nevalainen, T, Jylhävä, J, Mononen, N, Kähönen, M, Raitakari, O T, Lehtimäki, T, Hurme, M

“…Chronological aging-associated changes in the human DNA methylome have been studied by multiple epigenome-wide association studies (EWASs). Certain CpG sites…”
Get full text

Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19 by Kananen, L., Eriksdotter, M., Boström, A.M., Kivipelto, M., Annetorp, M., Metzner, C., Bäck Jerlardtz, V., Engström, M., Johnson, P., Lundberg, L.G., Åkesson, E., Sühl Öberg, C., Hägg, S., Religa, D., Jylhävä, J., Cederholm, T.

“…Overweight and obesity have been consistently reported to carry an increased risk for poorer outcomes in coronavirus disease 2019 (COVID-19) in adults…”
Get full text

Circulating cell-free DNA level predicts all-cause mortality independent of other predictors in the Health 2000 survey by Kananen, L., Hurme, M., Jylhä, M., Härkänen, T., Koskinen, S., Stenholm, S., Kähönen, M., Lehtimäki, T., Ukkola, O., Jylhävä, J.

“…Increased levels of circulating cell-free DNA (cf-DNA) are associated with and predict poor health outcomes. However, its predictive ability for mortality in…”
Get full text

Leukocyte telomere length and its relation to food and nutrient intake in an elderly population by Tiainen, A-MK, Männistö, S, Blomstedt, P A, Moltchanova, E, Perälä, M-M, Kaartinen, N E, Kajantie, E, Kananen, L, Hovatta, I, Eriksson, J G

“…Background/objectives: Shorter leukocyte telomere length (LTL) is associated with several chronic diseases, but only a few studies have assessed the…”
Get full text

The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies by Kananen, L., Marttila, S., Nevalainen, T., Kummola, L., Junttila, I., Mononen, N., Kähönen, M., Raitakari, O. T., Hervonen, A., Jylhä, M., Lehtimäki, T., Hurme, M., Jylhävä, J.

“…The epigenetic clock, defined as the DNA methylome age (DNAmAge), is a candidate biomarker of ageing. In this study, we aimed to characterize the behaviour of…”
Get full text

Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study by Nevalainen, T., Kananen, L., Marttila, S., Jylhä, M., Hervonen, A., Hurme, M., Jylhävä, J.

“…Aging is associated with a pro-inflammatory state, often referred to as inflammaging. The origin of the pro-inflammatory mediators and their role in the…”
Get full text

DNA methylation states in supercentenarians by Kananen, Laura

Get full text

Ageing-associated changes in DNA methylation in X and Y chromosomes by Kananen, Laura, Marttila, Saara

“…Ageing displays clear sexual dimorphism, evident in both morbidity and mortality. Ageing is also associated with changes in DNA methylation, but very little…”
Get full text

Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression by Marttila, Saara, Kananen, Laura, Häyrynen, Sergei, Jylhävä, Juulia, Nevalainen, Tapio, Hervonen, Antti, Jylhä, Marja, Nykter, Matti, Hurme, Mikko

“…Changes in DNA methylation are among the mechanisms contributing to the ageing process. We sought to identify ageing-associated DNA methylation changes at…”
Get full text

Childhood adversities are associated with shorter leukocyte telomere length at adult age in a population-based study (vol 130, 105276, 2021) by Ammala, A-J, Suvisaari, J, Kananen, L, Lonnqvist, J, Ripatti, S, Pirkola, S, Paunio, T, Hovatta, I

Get full text

Corrigendum to Childhood adversities are associated with shorter leukocyte telomere length at adult age in a population-based study [Psychoneuroendocrinology (2021) 130 105276] by Ämmälä, Antti-Jussi, Suvisaari, Jaana, Kananen, Laura, Lönnqvist, Jouko, Ripatti, Samuli, Pirkola, Sami, Paunio, Tiina, Hovatta, Iiris

Get full text

Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals by Nevalainen, Tapio, Kananen, Laura, Marttila, Saara, Jylhävä, Juulia, Mononen, Nina, Kähönen, Mika, Raitakari, Olli T, Hervonen, Antti, Jylhä, Marja, Lehtimäki, Terho, Hurme, Mikko

“…Human aging is associated with profound changes in one of the major epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like…”
Get full text

Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains by Kananen, L., Enroth, L., Raitanen, J., Jylhävä, J., Bürkle, A., Moreno-Villanueva, M., Bernhardt, J., Toussaint, O., Grubeck-Loebenstein, B., Malavolta, M., Basso, A., Piacenza, F., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Jansen, E. H. J. M., Dollé, M. E. T., Salmon, M., Stuetz, W., Weber, D., Grune, T., Breusing, N., Simm, A., Capri, M., Franceschi, C., Slagboom, P. E., Talbot, D. C. S., Libert, C., Koskinen, S., Bruunsgaard, H., Hansen, ÅM., Lund, R., Hurme, M., Jylhä, M.

“…Self-rated health (SRH) is one of the most frequently used indicators in health and social research. Its robust association with mortality in very different…”
Get full text

Response to Letter to the Editor: Comment on “Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19” (by Café Balcı, MD, Hacettepe University Faculty of Medicine Department of Internal Medicine Division of Geriatric Medicine) by Kananen, Laura, Religa, Dorota, Eriksdotter, Maria, Hägg, Sara, Julhävä, Juulia, Cederholm, Tommy

Get full text

Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses by Mak, Jonathan K. L., Kananen, Laura, Qin, Chenxi, Kuja‐Halkola, Ralf, Tang, Bowen, Lin, Jake, Wang, Yunzhang, Jääskeläinen, Tuija, Koskinen, Seppo, Lu, Yi, Magnusson, Patrik K. E., Hägg, Sara, Jylhävä, Juulia

“…Identifying metabolic biomarkers of frailty, an age‐related state of physiological decline, is important for understanding its metabolic underpinnings and…”
Get full text

Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden by Kananen, Laura, Hong, Xu, Annetorp, Martin, Mak, Jonathan K L, Jylhävä, Juulia, Eriksdotter, Maria, Hägg, Sara, Religa, Dorota

“…To analyse if the health progression of geriatric Covid-19 survivors three months after an acute Covid-19 infection was worse than in other geriatric patients…”
Get full text

Childhood adversities are associated with shorter leukocyte telomere length at adult age in a population-based study by Ämmälä, Antti-Jussi, Suvisaari, Jaana, Kananen, Laura, Lönnqvist, Jouko, Ripatti, Samuli, Pirkola, Sami, Paunio, Tiina, Hovatta, Iiris

“…Telomeres are repeat sequences and an associated protein complex located at the end of the chromosomes. They shorten with every cell division and are regarded…”
Get full text

Epigenome‐wide analysis of frailty: Results from two European twin cohorts by Mak, Jonathan K. L., Skovgaard, Asmus Cosmos, Nygaard, Marianne, Kananen, Laura, Reynolds, Chandra A., Wang, Yunzhang, Kuja‐Halkola, Ralf, Karlsson, Ida K., Pedersen, Nancy L., Hägg, Sara, Soerensen, Mette, Jylhävä, Juulia

“…Epigenetics plays an important role in the aging process, but it is unclear whether epigenetic factors also influence frailty, an age‐related state of…”
Get full text

Cytomegalovirus infection accelerates epigenetic aging by Kananen, Laura, Nevalainen, Tapio, Jylhävä, Juulia, Marttila, Saara, Hervonen, Antti, Jylhä, Marja, Hurme, Mikko

“…Epigenetic mechanisms such as DNA methylation (DNAm) have a central role in the regulation of gene expression and thereby in cellular differentiation and…”
Get full text

Development of an Electronic Frailty Index for Hospitalized Older Adults in Sweden by Mak, Jonathan K L, Hägg, Sara, Eriksdotter, Maria, Annetorp, Martin, Kuja-Halkola, Ralf, Kananen, Laura, Boström, Anne-Marie, Kivipelto, Miia, Metzner, Carina, Bäck Jerlardtz, Viktoria, Engström, Malin, Johnson, Peter, Lundberg, Lars Göran, Åkesson, Elisabet, Sühl Öberg, Carina, Olsson, Maria, Cederholm, Tommy, Jylhävä, Juulia, Religa, Dorota

“…Frailty assessment in the Swedish health system relies on the Clinical Frailty Scale (CFS), but it requires training, in-person evaluation, and is often…”
Get full text