Search Results - "Kanai, Maiko"
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Drosophila HOPS and AP-3 Complex Genes Are Required for a Deltex-Regulated Activation of Notch in the Endosomal Trafficking Pathway
Published in Developmental cell (01-11-2008)“…DSL ligands promote proteolysis of the Notch receptor, to release active Notch intracellular domain (NICD). Conversely, the E3 ubiquitin ligase Deltex can…”
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unconventional myosin in Drosophila reverses the default handedness in visceral organs
Published in Nature (06-04-2006)“…The internal organs of animals often have left-right asymmetry. Although the formation of the anterior-posterior and dorsal-ventral axes in Drosophila is well…”
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3
The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila
Published in Development (Cambridge) (01-04-2007)“…Notch is a transmembrane receptor that mediates the cell-cell interactions necessary for many cell-fate decisions. Endocytic trafficking of Notch plays…”
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Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells
Published in Genes to cells : devoted to molecular & cellular mechanisms (01-01-2007)“…Notch (N) and its ligands, Delta (Dl) and Serrate (Ser), are transmembrane proteins that mediate the cell–cell interactions necessary for many cell‐fate…”
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Head region of unconventional myosin I family members is responsible for the organ‐specificity of their roles in left–right polarity in Drosophila
Published in Developmental dynamics (01-12-2008)“…In Drosophila, Myosin31DF (Myo31DF), encoding a Myosin ID protein, has crucial roles in left–right (LR) asymmetric development. Loss of Myo31DF function leads…”
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Gbx2 functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid–hindbrain junction in a dosage- and stage-dependent manner
Published in Mechanisms of development (01-11-2013)“…•Both specification and morphogenesis of the isthmus are regulated by gbx2.•Transgenic fish allowing for conditional gbx2 upregulation has been…”
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Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila
Published in Development (Cambridge) (01-02-2012)“…The Notch (N) signaling machinery is evolutionarily conserved and regulates a broad spectrum of cell-specification events, through local cell-cell…”
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gbx2 Homeobox gene is required for the maintenance of the isthmic region in the zebrafish embryonic brain
Published in Developmental dynamics (01-11-2003)“…We isolated cDNA clones for the zebrafish gbx2 gene, which is implicated in the establishment of the midbrain–hindbrain boundary (MHB) in other vertebrates…”
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An unconventional myosin in Drosophila reverses the default handedness in visceral organs
Published in Nature (07-04-2006)“…The internal organs of animals often have left-right asymmetry. Although the formation of the anterior-posterior and dorsal-ventral axes in Drosophila is well…”
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Journal Article -
10
Three enhancer regions regulate gbx2 gene expression in the isthmic region during zebrafish development
Published in Mechanisms of development (01-12-2006)“…In vertebrate embryos, positioning of the boundary between the midbrain and hindbrain (MHB) and subsequent isthmus formation are dependent upon the interaction…”
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