A Case of Rapidly Growing Ovarian Squamous Cell Carcinoma Successfully Controlled by Weekly Paclitaxel–Carboplatin Administration

Background. Primary squamous cell carcinoma of the ovary is uncommon and has a poor prognosis. Because of its rarity, the effective postoperative treatment is unknown. We describe a remarkable response of this tumor to weekly paclitaxel–carboplatin administration. Case. A 53-year-old woman had rapid...

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Bibliographic Details
Published in:	Gynecologic oncology Vol. 79; no. 3; pp. 515 - 518
Main Authors:	Ohtani, Kaori, Sakamoto, Hideki, Masaoka, Naoki, Shimada, Kaoru, Kanaeda, Takeshi, Kurihara, Mari, Nagai, Nobuhisa, Satoh, Kazuo
Format:	Journal Article
Language:	English
Published:	San Diego, CA Elsevier Inc 01-12-2000 Elsevier
Subjects:	Abdominal Neoplasms - drug therapy Abdominal Neoplasms - secondary Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences carboplatin Carboplatin - administration & dosage Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Colonic Neoplasms - drug therapy Colonic Neoplasms - secondary Drug Administration Schedule Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery paclitaxel Paclitaxel - administration & dosage squamous cell carcinoma of the ovary Tumors weekly schedule weekly schedule paclitaxel squamous cell carcinoma of the ovary carboplatin Antineoplastic agent Human Drug combination Squamous cell carcinoma Malignant tumor Female genital diseases Case study Ovarian diseases Ovary Chemotherapy Treatment Taxane derivatives Paclitaxel Carboplatin Female Platinum II Complexes
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Summary:	Background. Primary squamous cell carcinoma of the ovary is uncommon and has a poor prognosis. Because of its rarity, the effective postoperative treatment is unknown. We describe a remarkable response of this tumor to weekly paclitaxel–carboplatin administration. Case. A 53-year-old woman had rapidly growing primary squamous cell carcinoma of the ovary that metastasized to the abdominal wall and transverse colon after maximum cytoreductive surgery. The tumor was resistant to primary chemotherapy with cisplatin, vincristine, mitomycin C, and bleomycin. A combination of paclitaxel and carboplatin was used for second-line chemotherapy and was repeated every week. The patient tolerated the chemotherapy well and demonstrated a pathological complete response in the abdominal metastases following the five courses of chemotherapy. Conclusion. Weekly paclitaxel–carboplatin administration may be a safe and effective treatment for advanced and rapidly growing ovarian squamous cell carcinoma with primary resistance to chemotherapy.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0090-8258 1095-6859
DOI:	10.1006/gyno.2000.5985