Search Results - "Kan, Yuxuan"

Raw and salt-processed Achyranthes bidentata attenuate LPS-induced acute kidney injury by inhibiting ROS and apoptosis via an estrogen-like pathway by Wang, Shengchao, Zeng, Mengnan, Li, Benke, Kan, Yuxuan, Zhang, Beibei, Zheng, Xiaoke, Feng, Weisheng

“…Radix Achyranthis Bidentatae has been used as a traditional Chinese herb of enriching kidney for thousands of years. The crude Achyranthis bidentatae is…”
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Protopine Protects Mice against LPS-Induced Acute Kidney Injury by Inhibiting Apoptosis and Inflammation via the TLR4 Signaling Pathway by Zhang, Beibei, Zeng, Mengnan, Li, Meng, Kan, Yuxuan, Li, Benke, Xu, Ruiqi, Wu, Yuanyuan, Wang, Shengchao, Zheng, Xiaoke, Feng, Weisheng

“…Migo is a traditional Chinese medicine that clears away damp heat, relieves sore. Protopine (PRO) is an alkaloid component isolated from Migo. However, the…”
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Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy by Yang, Chuanbin, Su, Chengfu, Iyaswamy, Ashok, Krishnamoorthi, Senthil Kumar, Zhu, Zhou, Yang, Sichang, Tong, Benjamin Chunkit, Liu, Jia, Sreenivasmurthy, Sravan G., Guan, Xinjie, Kan, Yuxuan, Wu, Aston Jiaxi, Huang, Alexis Shiying, Tan, Jieqiong, Cheung, Kingho, Song, Juxian, Li, Min

“…Alzheimer's disease (AD), characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates, is the most common neurodegenerative…”
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Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer's Disease by Guan, Xinjie, Iyaswamy, Ashok, Sreenivasmurthy, Sravan Gopalkrishnashetty, Su, Chengfu, Zhu, Zhou, Liu, Jia, Kan, Yuxuan, Cheung, King-Ho, Lu, Jiahong, Tan, Jieqiong, Li, Min

“…Eukaryotic cells possess a plethora of regulatory mechanisms to maintain homeostasis and ensure proper biochemical functionality. Autophagy, a central,…”
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Chinese yam extract and adenosine attenuated LPS-induced cardiac dysfunction by inhibiting RAS and apoptosis via the ER-mediated activation of SHC/Ras/Raf1 pathway by Zeng, Mengnan, Zhang, Li, Zhang, Beibei, Li, Benke, Kan, Yuxuan, Yang, Hang, Feng, Weisheng, Zheng, Xiaoke

“…This study aimed to examine the effects of the Chinese yam extract and adenosine on lipopolysaccharide (LPS)-induced cardiac anomalies and the underlying…”
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Corrigendum to “Raw and salt-processed Achyranthes bidentata attenuate LPS-induced acute kidney injury by inhibiting ROS and apoptosis via an estrogen-like pathway [Biomed. Pharmacother. 129 (2020) 110403]” by Wang, Shengchao, Zeng, Mengnan, Li, Benke, Kan, Yuxuan, Zhang, Beibei, Zheng, Xiaoke, Feng, Weisheng

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Camellia oil inhibits oxidative stress and inflammatory response to ameliorate LPS-induced acute kidney injury via downregulation of TLR4-mediated activation of the NF-κB/AP-1/IRF3 and NLRP3 pathways by Zeng, Mengnan, Li, Meng, Zhang, Beibei, Li, Benke, Kan, Yuxuan, Zheng, Xiaoke, Feng, Weisheng

“…[Display omitted] •Camellia oil had a protective effect on AKI by inhibiting TLR4 signaling.•Oleic acid was the most abundant component of camellia oil, which…”
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Editorial: Assessing the Pharmacological Effects and Therapeutic Potential of Traditional Chinese Medicine in Neurological Disease Models: An Update by Deng, Zhiqiang, Kan, Yuxuan, Li, Min, Song, Juxian, Lu, Jia-Hong

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Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics by Iyaswamy, Ashok, Lu, Kejia, Guan, Xin-Jie, Kan, Yuxuan, Su, Chengfu, Liu, Jia, Jaganathan, Ravindran, Vasudevan, Karthick, Paul, Jeyakumari, Thakur, Abhimanyu, Li, Min

“…Bacterial Extracellular Vesicles (BEVs) possess the capability of intracellular interactions with other cells, and, hence, can be utilized as an efficient…”
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Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer's Disease: A Review by Fung, Tsz Yan, Iyaswamy, Ashok, Sreenivasmurthy, Sravan G, Krishnamoorthi, Senthilkumar, Guan, Xin-Jie, Zhu, Zhou, Su, Cheng-Fu, Liu, Jia, Kan, Yuxuan, Zhang, Yuan, Wong, Hoi Leong Xavier, Li, Min

“…Alzheimer's disease (AD) is an age-associated neurodegenerative disease; it is the most common cause of senile dementia. Klotho, a single-pass transmembrane…”
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Corallodiscus flabellata B. L. Burtt extract alleviates lipopolysaccharide/D-galactosamine-induced acute liver failure and brain injury by inhibiting oxidative stress, apoptosis, and inflammation by Li, Benke, Zeng, Mengnan, Zhang, Beibei, Kan, Yuxuan, Wang, Shenchao, Wang, Yangyang, Wu, Yuanyuan, Xu, Ruiqi, Feng, Weisheng, Zheng, Xiaoke

“…B. L. Burtt (CF) is distributed along liver meridian, with a possible beneficial effect in the progression of acute liver failure. Therefore, the present study…”
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Arbutin attenuates LPS-induced acute kidney injury by inhibiting inflammation and apoptosis via the PI3K/Akt/Nrf2 pathway by Zhang, Beibei, Zeng, Mengnan, Li, Benke, Kan, Yuxuan, Wang, Shengchao, Cao, Bing, Huang, Yanjie, Zheng, Xiaoke, Feng, Weisheng

“…Arbutin (Ar) has anti-oxidative and anti-inflammatory activities. However, the effects of Ar on lipopolysaccharide (LPS)-induced acute kidney injury (AKI) are…”
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A new flavonoid from the thorn of Gleditsia sinensis Lam by Zeng, Mengnan, Qi, Man, Kan, Yuxuan, Zheng, Xiaoke, Feng, Weisheng

“…A new flavonoid, (2′′′E,6′′′S)-4′′-(6-hydroxy-2,6-dimethylocta-2,7-dienoyl)-vitexin (1), and five known compounds (2-6) were isolated from the thorn of…”
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Inhibitory activity of acteoside in melanoma via regulation of the ERβ-Ras/Raf1-STAT3 pathway by Wu, Yuanyuan, Zeng, Mengnan, Xu, Ruiqi, Zhang, Beibei, Wang, Shengchao, Li, Benke, Kan, Yuxuan, Cao, Bing, Zheng, Xiaoke, Feng, Weisheng

“…Melanoma is an aggressive cancer with a rapidly increasing incidence rate worldwide. Acteoside has been shown to have antitumor effects in multiple human…”
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Adenosine Attenuates LPS-Induced Cardiac Dysfunction by Inhibition of Mitochondrial Function via the ER Pathway by Zheng, Xiaoke, Wang, Shengchao, Kan, Yuxuan, Li, Benke, Zhang, Beibei, Zeng, Mengnan, Feng, Weisheng

“…Sepsis is a life-threatening organ dysfunction syndrome with a high rate of mortality. It is caused by an abnormal immune response to infection, and the…”
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Molecular engineering of a theranostic molecule that detects Aβ plaques, inhibits Iowa and Dutch mutation Aβ self-aggregation and promotes lysosomal biogenesis for Alzheimer's disease by Iyaswamy, Ashok, Wang, Xueli, Zhang, Hailong, Vasudevan, Karthick, Wankhar, Dapkupar, Lu, Kejia, Krishnamoorthi, Senthilkumar, Guan, Xin-Jie, Su, Cheng-Fu, Liu, Jia, Kan, Yuxuan, Jaganathan, Ravindran, Deng, Zhiqiang, Li, Hung-Wing, Wong, Man Shing, Li, Min

“…Extracellular clustering of amyloid-β (Aβ) and an impaired autophagy lysosomal pathway (ALP) are the hallmark features in the early stages of incurable…”
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Corallodiscus flabellata B.L. Burtt Extracts Stimulate Diuretic Activity and Regulate the Renal Expression of Aquaporins by Feng, Weisheng, Zheng, Xiaoke, Xu, Ruiqi, Wang, Yangyang, Wang, Shengchao, Li, Benke, Zhang, Beibei, Zeng, Mengnan, Kan, Yuxuan, Wu, Yuanyuan

“…Corallodiscus flabellata B. L. Burtt is a traditional Chinese medicine. Previous studies in our laboratory showed that C. flabellata alleviated symptoms of…”
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Acetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling by Xu, Ruiqi, Zeng, Mengnan, Wu, Yuanyuan, Wang, Shengchao, Zhang, Beibei, Zhang, Jingke, Kan, Yuxuan, Li, Benke, Cao, Bing, Zheng, Xiaoke, Feng, Weisheng

“…This research aims to investigate the intervention and mechanism of 50% acetone extract of leaves (SZYY) on melanoma xenografts. Tumor size and cardiac…”
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PPARɑ Ligand Caudatin Improves Cognitive Functions and Mitigates Alzheimer’s Disease Defects By Inducing Autophagy in Mice Models by Krishnamoorthi, Senthilkumar, Iyaswamy, Ashok, Sreenivasmurthy, Sravan Gopalkrishnashetty, Thakur, Abhimanyu, Vasudevan, Karthick, Kumar, Gaurav, Guan, Xin-Jie, Lu, Kejia, Gaurav, Isha, Su, Cheng-Fu, Zhu, Zhou, Liu, Jia, Kan, Yuxuan, Jayaraman, Selvaraj, Deng, Zhiqiang, Chua, Ka Kit, Cheung, King-Ho, Yang, Zhijun, Song, Ju-Xian, Li, Min

“…The autophagy-lysosomal pathway (ALP) is a major cellular machinery involved in the clearance of aggregated proteins in Alzheimer disease (AD). However, ALP is…”
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Inhibition of oxidative stress and autophagy by arbutin in lipopolysaccharide-induced myocardial injury by Zhang, Beibei, Zeng, Mengnan, Li, Benke, Wang, Yangyang, Kan, Yuxuan, Wang, Shengchao, Meng, Yijia, Gao, Jiji, Feng, Weisheng, Zheng, Xiaoke

“…Background: Sepsis is a syndrome characterized by a systemic inflammatory response. Arbutin (Ar) is an active natural product known for its bactericidal and…”
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