Search Results - "Kan, Y.W."

A Hypoxia-Regulated Adeno-Associated Virus Vector for Cancer-Specific Gene Therapy by Ruan, Hangjun, Sutt, Hua, Hu, Lily, Lamborn, Kathleen R., Kan, Y.W., Deen, Dennis F

“…The presence of hypoxic cells in human brain tumors is an important factor leading to resistance to radiation therapy. However, this physiological difference…”
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Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1 by CONBOY, J. G, CHAN, J. Y, CHASIS, J. A, YUET WAI KAN, MOHANDAS, N

“…Protein 4.1, a multifunctional structural protein originally described as an 80-kDa component of the erythroid membrane skeleton, exhibits tissue- and…”
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Fetal gene therapy of α-thalassemia in a mouse model by Han, Xiao-Dong, Lin, Chin, Chang, Judy, Sadelain, Michel, Kan, Y.W

“…Fetuses with homozygous α-thalassemia usually die at the third trimester of pregnancy or soon after birth. Hence, the disease could potentially be a target for…”
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343. Vascular Endothelial Growth Factor Prevents Bone Marrow Derived-Mesenchymal Stem Cell Senescence In Vitro by Pons, Jennifer, Su, Hua, Huang, Yu, Kan, Y.W.

“…Currently, adult bone marrow derived-mesenchymal stem cell (MSC) therapy is under investigation as a possible alternative for treatment of myocardial…”
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Low back pain and biomechanical characteristics of back muscles in firefighters by Kong, Pui W., Kan, Tommy Y. W., Bin Mohamed Jamil, Roslan Abdul Ghani, Teo, Wei P., Pan, Jing W., Hafiz Abd Halim, Noor, Kuddoos Abu Bakar Maricar, Hasan, Hostler, David

“…Firefighters often experience low back pain (LBP), but their back muscle characteristics are not well studied. This study aimed to 1) compare the biomechanical…”
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Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast by Chan, J.Y, Han, X.L, Kan, Y.W

“…We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper…”
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Rapid and Simultaneous Typing of Hemoglobin S, Hemoglobin C, and Seven Mediterranean β-Thalassemia Mutations by Covalent Reverse Dot-Blot Analysis: Application to Prenatal Diagnosis in Sicily by Maggio, A., Giambona, A., Cai, S.P., Wall, J., Kan, Y.W., Chehab, F.F.

“…The molecular lesions causing β-thalassemia in Sicily can be subdivided into two groups. One that occurs at a 71% frequency and consists of the β39, IVS 1,110…”
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5' nucleotide sequence of a putative human placental alkaline phosphatase-like gene by SHEN, L.-P, LIU, H, KAN, Y. W, KAM, W

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The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling by Ebina, Y, Ellis, L, Jarnagin, K, Edery, M, Graf, L, Clauser, E, Ou, J H, Masiarz, F, Kan, Y W, Goldfine, I D

“…A cloned approximately 5 kb cDNA (human placenta) contains the coding sequences for the insulin receptor. The nucleotide sequence predicts a 1382 amino acid…”
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Development of human single-chain antibodies against SARS-associated coronavirus by Leung, K M, Feng, D X, Lou, Jianlong, Zhou, Yu, Fung, K P, Waye, Mary M Y, Tsui, Stephen K W, Chan, Paul K S, Marks, James D, Pang, S F, Kan, Y W

“…The outbreak of severe acute respiratory syndrome (SARS), caused by a distinct coronavirus, in 2003 greatly threatened public health in China, Southeast Asia…”
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Monosomy 7 Myeloproliferative Disease in Children With Neurofibromatosis, Type 1: Epidemiology and Molecular Analysis by Shannon, K.M., Watterson, J., Johnson, P., O’Connell, P., Lange, B., Shah, N., Steinherz, P., Kan, Y.W., Priest, J.R.

“…Loss of constitutional heterozygosity is a common molecular feature of cancers in which inactivation of one or more tumor suppressor genes is thought to…”
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Molecular characterization of β-thalassemia in the Sardinian population by ROSATELLI, M. C, DOZY, A, FAA, V, MELONI, A, SARDU, R, SABA, L, KAN, Y. W, CAO, A

“…This study reports the molecular characterization of beta-thalassemia in the Sardinian population. Three thousand beta-thalassemia chromosomes from prospective…”
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Evidence implicating heterozygous deletion of chromosome 7 in the pathogenesis of familial leukemia associated with monosomy 7 by Shannon, K M, Turhan, A G, Rogers, P C, Kan, Y W

“…Complete or partial monosomy 7 is a recurring cytogenetic abnormality in acute myelogenous leukemia (AML) and myeloproliferative syndromes (MPS) and is…”
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Cloning of a cDNA for Steroid Sulfatase: Frequent Occurrence of Gene Deletions in Patients with Recessive X Chromosome-Linked Ichthyosis by Bonifas, Jeannette M., Morley, Bernard J., Oakey, Robert E., Kan, Yuet Wai, Epstein, Ervin H.

“…A human steroid sulfatase (steryl-sulfatase; steryl-sulfate sulfohydrolase, EC 3.1.6.2) cDNA 2.4 kilobases long was isolated from a human placental λ gt11 cDNA…”
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The Molecular Basis of β-Thalassemia in Lebanon: Application to Prenatal Diagnosis by Chehab, F.F., Der Kaloustian, V., Khouri, F.P., Deeb, S.S., Kan, Y.W.

“…A study of the molecular lesions of β-thalassemia in Lebanon revealed the presence of eight different mutations in 25 patients with Cooley’s anemia. The IVS1…”
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Detection of sickle cell anaemia mutation by colour DNA amplification by Chehab, F F, Kan, Y W

“…A fluorescence assay to detect the mutation in sickle cell anaemia has been developed. Oligonucleotides homologous to the normal or the mutant DNA sequence are…”
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A Novel β-Thalassemia Frameshift Mutation (Codon 14/15), Detectable by Direct Visualization of Abnormal Restriction Fragment in Amplified Genomic DNA by Chan, Vivian, Chan, T.K., Kan, Y.W., Todd, D.

“…A new frameshift mutation due to an insertion of G between codon 14/15 of the β-globin gene was found in two unrelated Chinese patients with Cooley's anemia…”
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Biogenesis of the Platelet Receptor for Fibrinogen: Evidence for Separate Precursors for Glycoproteins IIb and IIIa by Bray, Paul F., Rosa, Jean-Philippe, Lingappa, Vishwanath R., Kan, Yuet W., McEver, Rodger P., Shuman, Marc A.

“…Congenital absence of platelet glycoproteins IIb and IIIa (GPIIb and GPIIIa) results in a severe bleeding disorder characterized by defective platelet…”
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Amplification of a SV40 T antigen transgene is associated with sarcomagenesis in mice by Teitz, T, Yen, T S, Kan, Y W

“…Transgenic mice harboring simian virus 40 large T antigen (Tag) gene fused to an erythroid-specific enhancer developed soft tissue sarcomas which expressed…”
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Rapid Prenatal Diagnosis of β Thalassemia Using DNA Amplification and Nonradioactive Probes by Cai, S.-P., Chang, C.A., Zhang, J.-Z., Saiki, R.K., Erlich, H.A., Kan, Y.W.

“…We used in vitro DNA amplification by the polymerase chain reaction and nonradioactive probes for prenatal diagnosis of β thalassemia in Chinese from the…”
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