Search Results - "Kan, Winnie L."

The 10th Barossa meeting: Cell Signalling to Cancer Medicine by Kan, Winnie L., McClure, Barbara J., Hahn, Christopher N., Powell, Jason A.

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Role of the β Common (βc) Family of Cytokines in Health and Disease by Hercus, Timothy R, Kan, Winnie L T, Broughton, Sophie E, Tvorogov, Denis, Ramshaw, Hayley S, Sandow, Jarrod J, Nero, Tracy L, Dhagat, Urmi, Thompson, Emma J, Shing, Karen S Cheung Tung, McKenzie, Duncan R, Wilson, Nicholas J, Owczarek, Catherine M, Vairo, Gino, Nash, Andrew D, Tergaonkar, Vinay, Hughes, Timothy, Ekert, Paul G, Samuel, Michael S, Bonder, Claudine S, Grimbaldeston, Michele A, Parker, Michael W, Lopez, Angel F

“…The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which…”
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A dual role for the N-terminal domain of the IL-3 receptor in cell signalling by Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Kan, Winnie L., Barry, Emma F., Dottore, Mara, Cheung Tung Shing, Karen S., Morton, Craig J., Dhagat, Urmi, Hardy, Matthew P., Wilson, Nicholas J., Downton, Matthew T., Schieber, Christine, Hughes, Timothy P., Lopez, Angel F., Parker, Michael W.

“…The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and…”
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Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody by Broughton, Sophie E., Hercus, Timothy R., Hardy, Matthew P., McClure, Barbara J., Nero, Tracy L., Dottore, Mara, Huynh, Huy, Braley, Hal, Barry, Emma F., Kan, Winnie L., Dhagat, Urmi, Scotney, Pierre, Hartman, Dallas, Busfield, Samantha J., Owczarek, Catherine M., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.

“…Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the…”
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Cytotoxic Acylphloroglucinol Derivatives from the Twigs of Garcinia cowa by Xu, Gang, Kan, Winnie L. T, Zhou, Yan, Song, Jing-Zheng, Han, Quan-Bin, Qiao, Chun-Feng, Cho, Chi-Hin, Rudd, John A, Lin, Ge, Xu, Hong-Xi

“…An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B−D, 2−4)…”
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Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis by Tvorogov, Denis, Thomas, Daniel, Liau, Nicholas P D, Dottore, Mara, Barry, Emma F, Lathi, Maya, Kan, Winnie L, Hercus, Timothy R, Stomski, Frank, Hughes, Timothy P, Tergaonkar, Vinay, Parker, Michael W, Ross, David M, Majeti, Ravindra, Babon, Jeffrey J, Lopez, Angel F

“…Treatment of patients with myelofibrosis with the type I JAK (Janus kinase) inhibitor ruxolitinib paradoxically induces JAK2 activation loop phosphorylation…”
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CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting by Lim, Kelly, Kan, Winnie L, Nair, Pramod C, Kutyna, Monika, Lopez, Angel F, Hercus, Timothy, Ross, David M, Lane, Steven, Fong, Chun Yew, Brown, Anna, Yong, Agnes, Yeung, David, Hughes, Timothy, Hiwase, Devendra, Thomas, Daniel

“…Chronic myelomonocytic leukemia (CMML) is a rare blood cancer of older adults (3 in every 1,000,000 persons) characterized by poor survival and lacking…”
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The βc receptor family – Structural insights and their functional implications by Broughton, Sophie E., Nero, Tracy L., Dhagat, Urmi, Kan, Winnie L., Hercus, Timothy R., Tvorogov, Denis, Lopez, Angel F., Parker, Michael W.

“…•GM-CSF and IL-3 are pleiotropic cytokines with roles in health and disease.•New crystal structure of IL3Rα reveals novel open and closed…”
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Signalling by the βc family of cytokines by Hercus, Timothy R, Dhagat, Urmi, Kan, Winnie L.T, Broughton, Sophie E, Nero, Tracy L, Perugini, Michelle, Sandow, Jarrod J, D’Andrea, Richard J, Ekert, Paul G, Hughes, Timothy, Parker, Michael W, Lopez, Angel F

“…Abstract The GM-CSF, IL-3 and IL-5 family of cytokines, also known as the βc family due to their receptors sharing the signalling subunit βc, regulates…”
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Messing with βc: A unique receptor with many goals by Kan, Winnie L., Cheung Tung Shing, Karen S., Nero, Tracy L., Hercus, Timothy R., Tvorogov, Denis, Parker, Michael W., Lopez, Angel F.

“…•The βc cytokines are highly pleiotropic and contribute to many normal and pathological biological processes.•The structures and modes of assembly of βc…”
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The 10 th Barossa meeting: Cell Signalling to Cancer Medicine by Kan, Winnie L, McClure, Barbara J, Hahn, Christopher N, Powell, Jason A

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Accumulation of JAK Activation-Loop Phosphorylation Promotes Type I JAK Inhibitor Withdrawal Syndrome in Myelofibrosis by Tvorogov, Denis, Thomas, Daniel, Liau, Nicholas P.D, Dottore, Mara, Barry, Emma F, Lathi, Maya, Kan, Winnie L, Hercus, Tim R, Stomski, Frank, Hughes, Timothy P., Tergaonkar, Vinay, Parker, Michael W, Ross, David M, Babon, Jeffrey J, Majeti, Ravindra, Lopez, Angel F.

“…Patients with myelofibrosis who are treated with the Type I ATP competitive JAK inhibitor ruxolitinib derive symptomatic benefit from improvement in…”
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78: Insights into the function of an anti-leukaemia antibody: structural studies of CSL362 bound to soluble CD123 by Hercus, Tim R., Broughton, Sophie E., Hardy, Matthew P., Nero, Tracy L., McClure, Barbara J., Dottore, Mara, Dhagat, Urmi, Barry, Emma F., Kan, Winnie L., Busfield, Samantha J., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.

“…The ßc family of cytokines (GM-CSF, IL-3 and IL-5) are largely products of activated T cells and regulate the survival, proliferation, differentiation and…”
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78 by Hercus, Tim R., Broughton, Sophie E., Hardy, Matthew P., Nero, Tracy L., McClure, Barbara J., Dottore, Mara, Dhagat, Urmi, Barry, Emma F., Kan, Winnie L., Busfield, Samantha J., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.

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