Maternal gestational diabetes mellitus associates with altered gut microbiome composition and head circumference abnormalities in male offspring

The impact of gestational diabetes mellitus (GDM) on maternal or infant microbiome trajectory remains poorly understood. Utilizing large-scale longitudinal fecal samples from 264 mother-baby dyads, we present the gut microbiome trajectory of the mothers throughout pregnancy and infants during the fi...

Full description

Saved in:

Bibliographic Details
Published in:	Cell host & microbe Vol. 32; no. 7; p. 1192
Main Authors:	Wang, Shilan, Liu, Yingzhi, Tam, Wing Hung, Ching, Jessica Y L, Xu, Wenye, Yan, Shuai, Qin, Biyan, Lin, Ling, Peng, Ye, Zhu, Jie, Cheung, Chun Pan, Ip, Ka Long, Wong, Yuen Man, Cheong, Pui Kuan, Yeung, Yuk Ling, Kan, Wing Him Betty, Leung, Ting Fan, Leung, Tak Yeung, Chang, Eugene B, Rubin, David T, Claud, Erika C, Wu, William K K, Tun, Hein M, Chan, Francis K L, Ng, Siew C, Zhang, Lin
Format:	Journal Article
Language:	English
Published:	United States 10-07-2024
Subjects:	Adult Clostridium - growth & development Diabetes, Gestational - microbiology Feces - microbiology Female Gastrointestinal Microbiome Head - microbiology Humans Infant Infant, Newborn Male Pregnancy Prenatal Exposure Delayed Effects - microbiology metagenomic sequencing gut microbiome early life pregnancy head circumference index maternal health gestational diabetes mellitus gut-brain axis mother-infant transmission sex-dependent manner
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The impact of gestational diabetes mellitus (GDM) on maternal or infant microbiome trajectory remains poorly understood. Utilizing large-scale longitudinal fecal samples from 264 mother-baby dyads, we present the gut microbiome trajectory of the mothers throughout pregnancy and infants during the first year of life. GDM mothers had a distinct microbiome diversity and composition during the gestation period. GDM leaves fingerprints on the infant's gut microbiome, which are confounded by delivery mode. Further, Clostridium species positively correlate with a larger head circumference at month 12 in male offspring but not females. The gut microbiome of GDM mothers with male fetuses displays depleted gut-brain modules, including acetate synthesis I and degradation and glutamate synthesis II. The gut microbiome of female infants of GDM mothers has higher histamine degradation and dopamine degradation. Together, our integrative analysis indicates that GDM affects maternal and infant gut composition, which is associated with sexually dimorphic infant head growth.
ISSN:	1934-6069
DOI:	10.1016/j.chom.2024.06.005