Search Results - "Kan, Weijuan"

Inner nuclear membrane protein TMEM201 promotes breast cancer metastasis by positive regulating TGFβ signaling by Kong, Ya, Zhang, Yutian, Wang, Hanlin, Kan, Weijuan, Guo, Haoran, Liu, Yun, Zang, Yi, Li, Jia

“…Emerging evidence shows the association between nuclear envelope and tumor progression, however, the functional contributions of specific constituents of the…”
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Structure–Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors by Li, Chunpu, Su, Mingbo, Zhu, Wei, Kan, Weijuan, Ge, Tianpeng, Xu, Gaoya, Wang, Shuni, Sheng, Li, Gao, Feng, Ye, Yunfei, Wang, Jiang, Zhou, Yubo, Li, Jia, Liu, Hong

“…LSD1 is identified as an essential drug target, which is closely correlated to the development of several tumor types. In this work, on the basis of…”
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Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia by Wang, Hanlin, Luo, Guanghao, Hu, Xiaobei, Xu, Gaoya, Wang, Tao, Liu, Minmin, Qiu, Xiaohui, Li, Jianan, Fu, Jingfeng, Feng, Bo, Tu, Yutong, Kan, Weijuan, Wang, Chang, Xu, Ran, Zhou, Yubo, Yang, Jianmin, Li, Jia

“…The outcomes of FLT3-ITD acute myeloid leukaemia (AML) have been improved since the approval of FLT3 inhibitors (FLT3i). However, approximately 30-50% of…”
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Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis by Dong, Ying, Hu, Hao, Zhang, Xuan, Zhang, Yunkai, Sun, Xin, Wang, Hanlin, Kan, Weijuan, Tan, Min-jia, Shi, Hong, Zang, Yi, Li, Jia

“…Epithelial to mesenchymal transition (EMT) plays a crucial role in cancer metastasis, accompanied with vast epigenetic changes. AMP-activated protein kinase…”
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Targeted Near-Infrared Fluorescence Imaging of Liver Cancer using Dual-Peptide-Functionalized Albumin Particles by Dou, Wei-Tao, Guo, Chen, Zhu, Ling, Qiu, Peng, Kan, Weijuan, Pan, Yu-Fei, Zang, Yi, Dong, Li-Wei, Li, Jia, Tan, Ye-Xiong, Wang, Hong-Yang, He, Xiao-Peng

“…Fluorescence imaging is an emerging strategy for preoperative diagnosis and intraoperative resection. In particular, owing to their outstanding spatial…”
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Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton’s Tyrosine Kinase for the Treatment of Lymphoma by Zhang, Jingyu, Che, Jinxin, Luo, Xiaomin, Wu, Mingfei, Kan, Weijuan, Jin, Yuheng, Wang, Hanlin, Pang, Ao, Li, Cong, Huang, Wenhai, Zeng, Shenxin, Zhuang, Weihao, Wu, Yizhe, Xu, Yongjin, Zhou, Yubo, Li, Jia, Dong, Xiaowu

“…Bruton’s tyrosine kinase proteolysis-targeting chimeras (BTK-PROTACs) have emerged as a promising approach to address the limitations of BTK inhibitors…”
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Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico by Tang, Bixi, Xie, Like, Wang, Yangyang, Shi, Yulong, Kan, Weijuan, Feng, Bo, Lin, Chenxuan, Xu, Zhijian, Zhu, Weiliang, Li, Jia, Zhang, Xuemei, Tian, Xiaoting, Zang, Yi

“…Sepsis-induced acute lung injury (ALI) presents with significant morbidity and mortality in clinical settings. Tanreqing Injection (TRQI) has been clinically…”
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Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer by Wei, Dan, Wang, Hanlin, Zeng, Qinghe, Wang, Wenjing, Hao, Bingbing, Feng, Xule, Wang, Peipei, Song, Ning, Kan, Weijuan, Huang, Guifang, Zhou, Xiaoyu, Tan, Minjia, Zhou, Yubo, Huang, Ruimin, Li, Jia, Chen, Xiao-Hua

“…Triple-negative breast cancer (TNBC) is highly aggressive with very limited treatment options due to the lack of efficient targeted therapies and thus still…”
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Design and development of a series of 4-(piperazin-1-yl)pyrimidines as irreversible menin inhibitors by Luo, Menglan, Ye, Yunfei, Tang, Lu, Kan, Weijuan, Chen, Lin, Li, Cong, Sheng, Li, Zhou, Yubo, Li, Jia, Xiong, Bing, Wang, Hanlin, Chen, Danqi

“…The interaction between menin and MLL1 protein plays an important role in AML with MLL rearrangement and NPM1 mutation. Blocking the formation of menin-MLL…”
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Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity by Wang, Yuhong, Mi, Tian, Li, Yiming, Kan, Weijuan, Xu, Gaoya, Li, Jingya, Zhou, Yubo, Li, Jia, Jiang, Xuefeng

“…Lenalidomide and its analogs are well-known for treating multiple myeloma. In this work, designed sulfide-modified lenalidomide and pomalidomide were…”
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Discovery of Novel N‑(5-(Pyridin-3-yl)‑1H‑indazol-3-yl)benzamide Derivatives as Potent Cyclin-Dependent Kinase 7 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease by Yang, Bowen, Zhang, Haoran, Li, Na, Gao, Lixin, Jiang, Hong, Kan, Weijuan, Yuan, Haoxing, Li, Jia, Zhao, Dongmei, Xiong, Bing, Zhou, Yubo, Guo, Dong, Liu, Tongchao

“…Recent evidence suggests that CDK7 is a novel potential drug target for autosomal dominant polycystic kidney disease (ADPKD) treatment. Herein, on the basis of…”
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Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5‑((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile by Jin, Tingting, Xu, Lei, Wang, Peipei, Hu, Xiaobei, Zhang, Runyuan, Wu, Zhiqi, Du, Wenxin, Kan, Weijuan, Li, Kun, Wang, Chang, Zhou, Yubo, Li, Jia, Liu, Tao

“…Checkpoint kinase 1 (CHK1) plays an important role in the DNA damage response pathway, being a potential anti-cancer drug target. In this study, we used a…”
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Discovery of Novel N -(5-(Pyridin-3-yl)-1 H -indazol-3-yl)benzamide Derivatives as Potent Cyclin-Dependent Kinase 7 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease by Yang, Bowen, Zhang, Haoran, Li, Na, Gao, Lixin, Jiang, Hong, Kan, Weijuan, Yuan, Haoxing, Li, Jia, Zhao, Dongmei, Xiong, Bing, Zhou, Yubo, Guo, Dong, Liu, Tongchao

“…Recent evidence suggests that CDK7 is a novel potential drug target for autosomal dominant polycystic kidney disease (ADPKD) treatment. Herein, on the basis of…”
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Discovery of Novel 2-Aminopyridine-Based and 2-Aminopyrimidine-Based Derivatives as Potent CDK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors and Hematological Malignancies by Saidahmatov, Abdusaid, Li, Jianan, Xu, Shihao, Hu, Xiaobei, Gao, Xiangqian, Kan, Weijuan, Gao, Lixin, Li, Cong, Shi, Yuqiang, Sheng, Li, Wang, Peipei, Zhou, Yubo, Liang, Xuewu, Li, Jia, Liu, Hong

“…Co-inhibition of histone deacetylase (HDAC) and cyclin-dependent kinase (CDK) synergizes to produce enhanced antitumor effects and potentially overcomes the…”
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Discovery of a Highly Potent, Selective and Efficacious USP7 Degrader for the Treatment of Acute Lymphoblastic Leukemia by Xu, Miaomiao, Fu, Jingfeng, Pei, Yuan, Li, Mengna, Kan, Weijuan, Yan, Ruyu, Xia, Chaoyue, Ma, Jingkun, Wang, Peipei, Zhang, Yan, Gao, Yue, Yang, Yaxi, Zhou, Yubo, Li, Jia, Zhou, Bing

“…USP7 is an attractive therapeutic target for cancers, especially for acute lymphoblastic leukemia (ALL) with wild-type p53. Herein, we report the discovery of…”
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Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia by Han, Xu, Song, Ning, Saidahmatov, Abdusaid, Wang, Peipei, Wang, Yong, Hu, Xiaobei, Kan, Weijuan, Zhu, Wei, Gao, Lixin, Zeng, Mingjie, Wang, Yujie, Li, Chunpu, Li, Jia, Liu, Hong, Zhou, Yubo, Wang, Jiang

“…CDK9 is an essential drug target correlated to the development of acute myeloid leukemia (AML). Starting from the hit compound 10, which was discovered through…”
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Ardisiphenol D, a resorcinol derivative identified from Ardisia brevicaulis, exerts antitumor effect through inducing apoptosis in human non-small-cell lung cancer A549 cells by Zhao, Feng, Hu, Yuan, Chong, Chuanke, Lu, Minghui, Chen, Liping, Kan, Weijuan, Chen, Lei, Liu, Hongwei

“…The in vitro and in vivo antitumor activities of ardisiphenol D, a natural product isolated from the roots of Ardisa brevicaulis Diels (Myrsinaceae), have been…”
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