Search Results - "Kan, V. V."

VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex by Lu, Kan V., Chang, Jeffrey P., Parachoniak, Christine A., Pandika, Melissa M., Aghi, Manish K., Meyronet, David, Isachenko, Nadezda, Fouse, Shaun D., Phillips, Joanna J., Cheresh, David A., Park, Morag, Bergers, Gabriele

“…Inhibition of VEGF signaling leads to a proinvasive phenotype in mouse models of glioblastoma multiforme (GBM) and in a subset of GBM patients treated with…”
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A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma by Barnes, J. Matthew, Kaushik, Shelly, Bainer, Russell O., Sa, Jason K., Woods, Elliot C., Kai, FuiBoon, Przybyla, Laralynne, Lee, Mijeong, Lee, Hye Won, Tung, Jason C., Maller, Ori, Barrett, Alexander S., Lu, Kan V., Lakins, Jonathon N., Hansen, Kirk C., Obernier, Kirsten, Alvarez-Buylla, Arturo, Bergers, Gabriele, Phillips, Joanna J., Nam, Do-Hyun, Bertozzi, Carolyn R., Weaver, Valerie M.

“…Glioblastoma multiforme (GBMs) are recurrent lethal brain tumours. Recurrent GBMs often exhibit mesenchymal, stem-like phenotypes that could explain their…”
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Mechanisms of evasive resistance to anti-VEGF therapy in glioblastoma by Lu, Kan V, Bergers, Gabriele

“…Angiogenesis inhibitors targeting the VEGF signaling pathway have been US FDA approved for various cancers including glioblastoma (GBM), one of the most lethal…”
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The Effect of Statins on Mortality in Patients with Bacteremia by Liappis, A. P., Kan, V. L., Rochester, C.G., Simon, G.L.

“…The statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, act to regulate the biosynthesis of cholesterol. Statins also deplete nonsterol…”
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Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors by Mellinghoff, Ingo K, Wang, Maria Y, Vivanco, Igor, Haas-Kogan, Daphne A, Zhu, Shaojun, Dia, Ederlyn Q, Lu, Kan V, Yoshimoto, Koji, Huang, Julie H.Y, Chute, Dennis J, Riggs, Bridget L, Horvath, Steve, Liau, Linda M, Cavenee, Webster K, Rao, P. Nagesh, Beroukhim, Rameen, Peck, Timothy C, Lee, Jeffrey C, Sellers, William R, Stokoe, David, Prados, Michael, Cloughesy, Timothy F, Sawyers, Charles L, Mischel, Paul S

“…A small proportion of glioblastomas respond to gefitinib or erlotinib (tyrosine kinase inhibitors). Some of these responsive tumors have a mutant variant of…”
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Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells by WANG, Maria Y, LU, Kan V, MISCHEL, Paul S, SHAOJUN ZHU, DIA, Ederlyn Q, VIVANCO, Igor, SHACKLEFORD, Gregory M, CAVENEE, Webster K, MELLINGHOFF, Ingo K, CLOUGHESY, Timothy F, SAWYERS, Charles L

“…The epidermal growth factor receptor (EGFR) is commonly amplified, overexpressed, and mutated in glioblastoma, making it a compelling molecular target for…”
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Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting by OSTROSKY-ZEICHNER, L, SABLE, C, NUCCI, M, PAPPAS, P. G, BRADLEY, M. E, MAJOR, S, ZIMMER, L, WALLACE, D, DISMUKES, W. E, REX, J. H, SOBEL, J, ALEXANDER, B. D, DONOWITZ, G, KAN, V, KAUFFMAN, C. A, KETT, D, LARSEN, R. A, MORRISON, V

“…The study presented here was performed in order to create a rule that identifies subjects at high risk for invasive candidiasis in the intensive care setting…”
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Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients by LU, Kan V, SHAOJUN ZHU, LEE, Yohan, ZUGEN CHEN, CALDWELL, Jeremy S, YONGMIN XIE, LOO, Joseph A, SELIGSON, David, CHAKRAVARI, Arnab, LEE, Francis Y, WEINMANN, Roberto, CLOUGHESY, Timothy F, CVRLJEVIC, Anna, NELSON, Stanley F, BERGERS, Gabriele, GRAEBER, Thomas, FURNARI, Frank B, JAMES, C. David, CAVENEE, Webster K, JOHNS, Terrance G, MISCHEL, Paul S, HUANG, Tiffany T, SARKARIA, Shawn, AHKAVAN, David, DANG, Julie, DINCA, Eduard B, PLAISIER, Seema B, ODERBERG, Isaac

“…Activating epidermal growth factor receptor (EGFR) mutations are common in many cancers including glioblastoma. However, clinical responses to EGFR inhibitors…”
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Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM by McKinney, Andrew, Lindberg, Olle R, Engler, Jane R, Chen, Katharine Y, Kumar, Anupam, Gong, Henry, Lu, Kan V, Simonds, Erin F, Cloughesy, Timothy F, Liau, Linda M, Prados, Michael, Bollen, Andrew W, Berger, Mitchel S, Shieh, Joseph T C, James, C David, Nicolaides, Theodore P, Yong, William H, Lai, Albert, Hegi, Monika E, Weiss, William A, Phillips, Joanna J

“…Amplification of the epidermal growth factor receptor gene ( ) represents one of the most commonly observed genetic lesions in glioblastoma (GBM); however,…”
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Interaction of Heavy Drinking Patterns and Depression Severity Predicts Efficacy of Quetiapine Fumarate XR in Lowering Alcohol Intake in Alcohol Use Disorder Patients by Vatsalya, Vatsalya, Kong, Maiying, Marsano, Luis M, Kurlawala, Zimple, Chandras, Kan V, Schwandt, Melanie L, Ramchandani, Vijay A, McClain, Craig J

“…Background: Shared etiological pathways of dopamine and serotonin neurotransmission play a central role in heavy alcohol intake and exacerbation in the…”
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Reconstruction of the Internal-Wave Parameters in the Atmosphere from Signal Amplitude Fluctuations in a Radio-Occultation Experiment by Kan, V., Gorbunov, M. E., Shmakov, A. V., Sofieva, V. F.

“…In this paper, we discuss a method for reconstructing the parameters of internal gravitational waves (IGWs) in the stratosphere from amplitude fluctuations in…”
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Variable anisotropy of small-scale stratospheric irregularities retrieved from stellar scintillation measurements by GOMOS/Envisat by Kan, V, Sofieva, V. F, Dalaudier, F

“…In this paper, we consider possibilities for studying the anisotropy of small-scale air density irregularities using satellite observations of bi-chromatic…”
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Practice Guidelines for Diseases Caused by Aspergillus by Kan, Virginia L., Judson, Marc A., Morrison, Vicki A., Dummer, Stephen, Denning, David W., Bennett, John E., Walsh, Thomas J., Patterson, Thomas F., Pankey, George A.

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Comparative Multi-Modal, Multi-Scale Residual Stress Evaluation in SLM 3D-Printed Al-Si-Mg Alloy (RS-300) Parts by Statnik, Eugene S., Uzun, Fatih, Lipovskikh, Svetlana A., Kan, Yuliya V., Eleonsky, Sviatoslav I., Pisarev, Vladimir S., Somov, Pavel A., Salimon, Alexey I., Malakhova, Yuliya V., Seferyan, Aleksandr G., Ryabov, Dmitry K., Korsunsky, Alexander M.

“…SLM additive manufacturing has demonstrated great potential for aerospace applications when structural elements of individual design and/or complex shape need…”
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Changes in Brain Electrical Activity after Transient Middle Cerebral Artery Occlusion in Rats by Sysoev, Yuriy I., Prikhodko, Veronika A., Kan, Aleksandra V., Titovich, Irina A., Karev, Vadim E., Okovityi, Sergey V.

“…Objectives. Ischemic stroke is a leading cause of death and disability worldwide. To search for new therapeutic and pharmacotherapeutic strategies, numerous…”
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Identification of molecular subtypes of glioblastoma by gene expression profiling by MISCHEL, Paul S, SHAI, Ruty, CLOUGHESY, Timothy F, NELSON, Stanley F, TAO SHI, HORVATH, Steve, LU, Kan V, GHEEYOUNG CHOE, SELIGSON, David, KREMEN, Thomas J, PALOTIE, Aarno, LIAU, Linda M

“…Epidermal growth factor receptor (EGFR) overexpression occurs in nearly 50% of cases of glioblastoma (GBM), but its clinical and biological implications are…”
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Differential Induction of Glioblastoma Migration and Growth by Two Forms of Pleiotrophin by Lu, Kan V., Jong, Kimberly A., Kim, Gloria Y., Singh, Jatinder, Dia, Ederlyn Q., Yoshimoto, Koji, Wang, Maria Y., Cloughesy, Timothy F., Nelson, Stanley F., Mischel, Paul S.

“…Glioblastoma is the most common malignant brain tumor of adults and one of the most lethal cancers. The secreted growth factor pleiotrophin (PTN) promotes…”
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The Structure and Electrophysical Properties of Multiwall Carbon Nanotubes Subjected to Argon Ion Bombardment by Knyazev, E. V., Bolotov, V. V., Ivlev, K. E., Povoroznyuk, S. N., Kan, V. E., Sokolov, D. V.

“…The morphology, structure, and electrophysical characteristics of multiwall carbon nanotubes (MWCNTs), as affected by defects induced by ion bombardment, are…”
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Broadly Reactive Nanobody Targeting the H3 Hemagglutinin of the Influenza A Virus by Shcheblyakov, D V, Voronina, D V, Favorskaya, I A, Esmagambetov, I B, Alekseeva, I A, Korobkova, A I, Ryabova, E I, Derkaev, A A, Kan, V Yu, Dzharullaeva, A Sh, Tukhvatulin, A I, Bandelyuk, A S, Shmarov, M M, Logunov, D Yu, Gintsburg, A L

“…Monoclonal antibodies and recombinant antibody fragments are a very promising therapeutic tool to combat infectious diseases. Due to their unique paratope…”
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Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line by Lu, Kan V, Jong, Kimberly A, Rajasekaran, Ayyappan K, Cloughesy, Timothy F, Mischel, Paul S

“…Local invasiveness is a characteristic feature of glioblastoma that makes surgical resection nearly impossible and accounts in large part for its poor…”
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