Search Results - "Kan, Lynn"

Evaluation of potential endocrine activity of 2,4-dichlorophenoxyacetic acid using in vitro assays by Coady, Katherine K., Lynn Kan, H., Schisler, Melissa R., Bhaskar Gollapudi, B., Neal, Barbara, Williams, Amy, LeBaron, Matthew J.

“…•2,4-D was negative for endocrine activity in in vitro assays of the EDSP Tier 1 screening battery.•2,4-D does not interact in vitro with the estrogen,…”
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Mechanism of trifluralin-induced thyroid tumors in rats by Saghir, Shakil A., Charles, Grantley D., Bartels, Michael J., Kan, Lynn H.L., Dryzga, Mark D., Brzak, Kathy A., Clark, Amy J.

“…Trifluralin, an herbicide, has been reported to cause a significant increase in thyroid follicular cell tumors in male Fischer 344 rats. This study was…”
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Analysis of the interaction of phytoestrogens and synthetic chemicals: An in vitro/in vivo comparison by Charles, Grantley D., Gennings, Chris, Tornesi, Belen, Kan, H. Lynn, Zacharewski, Timothy R., Bhaskar Gollapudi, B., Carney, Edward W.

“…In the evaluation of chemical mixture toxicity, it is desirable to develop an evaluation paradigm which incorporates some critical attributes of real world…”
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Background Gene Expression in Rat Kidney: Influence of Strain, Gender, and Diet by Seidel, Shawn D., Hung, Shao-Ching, Lynn Kan, H, Bhaskar Gollapudi, B

“…In order to gain better insight into factors (strain, gender, and diet) influencing background variability in kidney gene expression, we examined the…”
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An in vitro developmental neurotoxicity screening assay for retinoic acid-induced neuronal differentiation using the human NT2/D1 cell line by Taylor, Matthew A., Kan, H. Lynn, Gollapudi, B. Bhaskar, Marty, M. Sue

“…Traditional approaches (e.g., neurobehavior, neuropathology) can detect alterations in apical endpoints indicative of developmental neurotoxicity (DNT)…”
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Characterization of nuclear receptor-mediated murine hepatocarcinogenesis of the herbicide pronamide and its human relevance by LeBaron, Matthew J, Rasoulpour, Reza J, Gollapudi, B Bhaskar, Sura, Radhakrishna, Kan, H Lynn, Schisler, Melissa R, Pottenger, Lynn H, Papineni, Sabitha, Eisenbrandt, David L

“…The key events responsible for mouse liver tumors induced by a pesticide (viz., pronamide) were investigated in a series of studies employing molecular,…”
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An integrated approach for prospectively investigating a mode-of-action for rodent liver effects by LeBaron, Matthew J., Geter, David R., Rasoulpour, Reza J., Gollapudi, B. Bhaskar, Thomas, Johnson, Murray, Jennifer, Kan, H. Lynn, Wood, Amanda J., Elcombe, Cliff, Vardy, Audrey, McEwan, Jillian, Terry, Claire, Billington, Richard

“…Registration of new plant protection products (e.g., herbicide, insecticide, or fungicide) requires comprehensive mammalian toxicity evaluation including…”
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Tiered application of the neutral red release and EpiOcular™ assays for evaluating the eye irritation potential of agrochemical formulations by Settivari, Raja S., Amado, Ricardo Acosta, Corvaro, Marco, Visconti, Nicolo R., Kan, Lynn, Carney, Edward W., Boverhof, Darrell R., Gehen, Sean C.

“…Agrochemical formulations have been underrepresented in validation efforts for implementing alternative eye irritation approaches but represent a significant…”
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Genetic damage, but limited evidence of oxidative stress markers in diethyl maleate-induced glutathione depleted mouse lymphoma L5178Y (TK+/-) cell cultures by Geter, David R., Zhang, Fagen, Schisler, Melissa R., Wood, Amanda J., Kan, H. Lynn, Jeong, Yo-Chan, Bartels, Michael J., McFadden, Lisa, Gollapudi, B. Bhaskar

“…Depletion of glutathione (GSH) in cells exposed to certain xenobiotics has been proposed to result in oxidative stress, which could lead to damage of cellular…”
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Aryl hydrocarbon receptor mode-of-action and human relevance framework for halauxifen-methyl induced rodent liver effects by Murphy, Lynea, LeBaron, Matthew, Marshall, Valerie, McCoy, Alene, Kan, Lynn, Boverhof, Darrell, Bartels, Michael, Terry, Claire, Billington, Richard, Rasoulpour, Reza

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A comparison of in vitro and in vivo EDSTAC test battery results for detecting antiandrogenic activity by Charles, Grantley D., Kan, H.Lynn, Schisler, Melissa R., Bhaskar Gollapudi, B., Sue Marty, M.

“…The androgen receptor (AR) transactivation, binding, and Hershberger assays are being developed for large-scale screening of chemicals for endocrine activity…”
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Investigations of Oxidative Stress, Antioxidant Response, and Protein Binding in Chlorpyrifos Exposed Rat Neuronal PC12 Cells by Geter, David R., Kan, H. Lynn, Lowe, Ezra R., Rick, David L., Charles, Grantley D., Gollapudi, Bhaskar B., Mattsson, Joel L.

“…ABSTRACT Chlorpyrifos (CPF) is a widely used organophosphate insecticide. In addition to its known properties of cholinesterase inhibition, the production of…”
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In vitro metabolism and covalent binding of ethylbenzene to microsomal protein as a possible mechanism of ethylbenzene-induced mouse lung tumorigenesis by Saghir, Shakil A., Zhang, Fagen, Rick, David L., Kan, Lynn, Bus, James S., Bartels, Michael J.

“…This study was conducted to determine species differences in covalent binding of the reactive metabolites of ethylbenzene (EB) formed in the liver and lung…”
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Authors response to Huff et al., “Clarifying carcinogenicity of ethylbenzene” by Saghir, Shakil A., Zhang, Fagen, Rick, David L., Kan, Lynn, Bus, James S., Bartels, Michael J.

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Quantitation of glutathione by liquid chromatography/positive electrospray ionization tandem mass spectrometry by Zhang, Fagen, Bartels, Michael J., Geter, David R., Jeong, Yo-Chan, Schisler, Melissa R., Wood, Amanda J., Kan, Lynn, Gollapudi, B. Bhaskar

“…Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine. It is present in practically all cells and has several important roles, such as…”
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Identification of transcriptome profiles for the DNA-damaging agents bleomycin and hydrogen peroxide in L5178Y mouse lymphoma cells by Seidel, Shawn D., Kan, H. Lynn, Stott, William T., Schisler, Melissa R., Gollapudi, B. Bhaskar

“…It is believed that some aspects of genotoxicity are associated with changes in the transcription levels of certain genes, especially those involved in DNA…”
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Gene Expression Dose-Response of Liver with a Genotoxic and Nongenotoxic Carcinogen by Seidel, Shawn D., Stott, William T., Kan, H. Lynn, Sparrow, Barney R., Gollapudi, B. Bhaskar

“…Tumorigenic mechanisms due to chemical exposure are broadly classified as either genotoxic or nongenotoxic. Genotoxic mechanisms are generally well defined;…”
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Haloalkane Dehalogenases:  Structure of a Rhodococcus Enzyme by Newman, Janet, Peat, Thomas S, Richard, Ruth, Kan, Lynn, Swanson, Paul E, Affholter, Joseph A, Holmes, Ian H, Schindler, John F, Unkefer, Clifford J, Terwilliger, Thomas C

“…The hydrolytic haloalkane dehalogenases are promising bioremediation and biocatalytic agents. Two general classes of dehalogenases have been reported from…”
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Profiles of gene expression changes in L5178Y mouse lymphoma cells treated with methyl methanesulfonate and sodium chloride by Seidel, Shawn D., Sparrow, Barney R., Kan, H.Lynn, Stott, William T., Schisler, Melissa R., Linscombe, V.Ann, Gollapudi, B.Bhaskar

“…Treatment of cells with genotoxic chemicals is expected to set into motion a series of events including gene expression changes to cope with the damage. We…”
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Comparative evaluation of (Q)SAR models for predicting genotoxicity endpoints by Osterloh-Quiroz, Mandy, Kan, Lynn, Kleinert, Kathryn M., Boverhof, Darrell R.

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