Search Results - "Kan, Kelvin K. W."

Bis(7)‐tacrine attenuates β amyloid‐induced neuronal apoptosis by regulating L‐type calcium channels by Fu, Hongjun, Li, Wenming, Lao, Yuanzhi, Luo, Jialie, Lee, Nelson T. K., Kan, Kelvin K. W., Tsang, Hing Wai, Tsim, Karl W. K., Pang, Yuanping, Li, Zhiwang, Chang, Donald C., Li, Mingtao, Han, Yifan

“…β Amyloid protein (Aβ) and acetylcholinesterase (AChE) have been shown to be closely implicated in the pathogenesis of Alzheimer's disease. In the current…”
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Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase by Li, Wenming, Xue, Jian, Niu, Chunying, Fu, Hongjun, Lam, Colin S C, Luo, Jialie, Chan, Hugh H N, Xue, Huaiguo, Kan, Kelvin K W, Lee, Nelson T K, Li, Chaoying, Pang, Yuanping, Li, Mingtao, Tsim, Karl W K, Jiang, Hualiang, Chen, Kaixian, Li, Xiaoyuan, Han, Yifan

“…The excessive activation of the N-methyl-D-aspartate receptor (NMDAR)/nitric oxide (NO) pathway has been proposed to be involved in the neuropathology of…”
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The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine by Yu, Hua, Li, Wen-Ming, Kan, Kelvin K.W., Ho, Jason M.K., Carlier, Paul R., Pang, Yuan-Ping, Gu, Zhe-Ming, Zhong, Zuo, Chan, Kelvin, Wang, Yi-Tao, Han, Yi-Fan

“…The lipophilicity and solubility profiles of bis(12)-hupyridone (B12H) and bis(7)-tacrine (B7T), two novel acetylcholinesterase inhibitors dimerized from…”
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Role of prostanoid EP3/1 receptors in mechanisms of emesis and defaecation in ferrets by Kan, Kelvin K.W., Wai, Man K., Jones, Robert L., Rudd, John A.

“…Prostanoid EP receptor agonists are used for a number of clinical indications but may be associated with gastric disturbance. In the present studies we used…”
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Simultaneous determination of ergosterol, nucleosides and their bases from natural and cultured Cordyceps by pressurised liquid extraction and high-performance liquid chromatography by Li, S.P, Li, P, Lai, C.M, Gong, Y.X, Kan, Kelvin K.W, Dong, Tina T.X, Tsim, Karl W.K, Wang, Y.T

“…A simple method is described for the simultaneous determination of ergosterol, nucleosides and their bases in Cordyceps. The samples were extracted by using…”
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Optimization of pressurized liquid extraction for Z-ligustilide, Z-butylidenephthalide and ferulic acid in Angelica sinensis by Li, P., Li, S.P., Lao, S.C., Fu, C.M., Kan, Kelvin K.W., Wang, Y.T.

“…Pressurized liquid extraction, one of the most promising and recent sample preparation techniques, offers the advantages of reducing solvent consumption and…”
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Differential action of anti-emetic drugs on defecation and emesis induced by prostaglandin E2 in the ferret by KAN, Kelvin K. W, RUDD, John A, WAI, Man K

“…In the present studies we investigated the mechanism of action of prostaglandin E2 (1 mg/kg, i.p.) to induce emesis and defecation and/or tenesmus in the…”
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Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine by Li, Wenming, Lee, Nelson T.K, Fu, Hongjun, Kan, Kelvin K.W, Pang, Yuanping, Li, Mingtao, Tsim, Karl W.K, Li, Xiaoyuan, Han, Yifan

“…Here we report that bis(7)-tacrine, a novel acetylcholinesterase inhibitor, exerts neuroprotective effects by inhibition of nitric oxide synthase. In cortical…”
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Mechanism of the prostanoid TP receptor agonist U46619 for inducing emesis in the ferret by Kan, Kelvin K. W., Ngan, Man P., Wai, Man K., Rudd, John A.

“…U46619 is a potent thromboxane A 2 mimetic with emesis-inducing actions that are mediated via prostanoid TP receptors. We investigated its emetic mechanism of…”
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Alkylene tether-length dependent γ-aminobutyric acid type A receptor competitive antagonism by tacrine dimers by Li, Chaoying, Carlier, Paul R., Ren, Hong, Kan, Kelvin K.W., Hui, Kwokmin, Wang, Hong, Li, Wenming, Li, Zhiwang, Xiong, Keming, Clement, Ella Chow, Xue, Hong, Liu, Xiangou, Li, Mingtao, Pang, Yuanping, Han, Yifan

“…Bis(7)-tacrine was previously demonstrated as an antagonist of γ-aminobutyric acid type A (GABA A) receptors. In this study, the effects of a series of…”
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Action of 5-HT3 receptor antagonists and dexamethasone to modify cisplatin-induced emesis in Suncus murinus (house musk shrew) by SAM, Tasia S. W, CHENG, Jimmy T. Y, JOHNSTON, Kevin D, KAN, Kelvin K. W, NGAN, Man P, RUDD, John A, WAI, Man K, YEUNG, John H. K

“…Ondansetron (1-3 mg/kg), granisetron (0.3-1 mg/kg) and dexamethasone (0.3-1 mg/kg), administered at 12-h intervals, were investigated for their potential to…”
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Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood by Yu, Hua, Ho, Jason M.K., Kan, Kelvin K.W., Cheng, Bobby W.H., Li, Wen-Ming, Zhang, Li, Lin, Ge, Pang, Yuan-Ping, Gu, Zhe-Ming, Chan, Kelvin, Wang, Yi-Tao, Han, Yi-Fan

“…An analytical method using on-line high performance liquid chromatography-tandem mass spectrometry with electrospray ionization was developed and applied for…”
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Actions of prostanoids to induce emesis and defecation in the ferret by Kan, Kelvin K.W, Jones, Robert L, Ngan, Man-Pui, Rudd, John A

“…Several prostanoids were investigated for their ability to induce emesis and/or defecation and tenesmus in the ferret. The rank order of emetic potency (dose…”
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Action of ondansetron and CP-99,994 to modify behavior and antagonize cisplatin-induced emesis in the ferret by Lau, Angie H.Y., Kan, Kelvin K.W., Lai, Helen W., Ngan, Man-P., Rudd, John A., Wai, Man-K., Yew, David T.W.

“…The action of ondansetron (1 mg/kg, i.p.) and (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine (CP-99,994; 10 mg/kg, i.p.) on spontaneous behavior and…”
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Excitatory action of prostanoids on the ferret isolated vagus nerve preparation by Kan, Kelvin K.W., Jones, Robert L., Ngan, Man-Pui, Rudd, John A.

“…We have investigated the actions of various prostanoid receptor agonists on an isolated preparation of the ferret cervical vagus using a grease-gap…”
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Action of prostanoids on the emetic reflex of Suncus murinus (the house musk shrew) by Kan, Kelvin K.W., Jones, Robert L., Ngan, Man-P., Rudd, John A.

“…Several prostanoids were investigated for a potential to induce emesis in Suncus murinus. The TP receptor agonist 11α,9α-epoxymethano-15 S-hydroxyprosta-5 Z,13…”
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Emetic action of the prostanoid TP receptor agonist, U46619, in Suncus murinus (house musk shrew) by Kan, Kelvin K.W., Jones, Robert L., Ngan, Man-P., Rudd, John A., Wai, Man-K.

“…The emetic action of the prostanoid TP receptor agonist, 11α,9α-epoxymethano-15 S-hydroxyprosta-5 Z,13 E-dienoic acid (U46619; 300 μg/kg, i.p.), was…”
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Action of metyrapone and tetracosactrin to modify cisplatin-induced acute and delayed emesis in the ferret by Sam, Tasia S.W., Kan, Kelvin K.W., Ngan, Man P., Rudd, John A., Yeung, John H.K.

“…Cisplatin 5 mg/kg, i.p., induced an acute (day 1) and delayed (days 2 and 3) emetic response in the ferret that was used to investigate the potential…”
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Role of prostanoid EP 3/1 receptors in mechanisms of emesis and defaecation in ferrets by Kan, Kelvin K W, Wai, Man K, Jones, Robert L, Rudd, John A

“…Prostanoid EP receptor agonists are used for a number of clinical indications but may be associated with gastric disturbance. In the present studies we used…”
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Identification and quantification of 13 components in Angelica sinensis (Danggui) by gas chromatography–mass spectrometry coupled with pressurized liquid extraction by Lao, S.C., Li, S.P., Kan, Kelvin K.W., Li, P., Wan, J.B., Wang, Y.T., Dong, Tina T.X., Tsim, Karl W.K.

“…Angelica sinensis (Danggui in Chinese), a well-known traditional Chinese medicine, is also used as a health food product for women's care in Europe and…”
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