Search Results - "Kan, Jason W. Y"

A New Class of Safe, Potent, and Specific P‑gp Modulator: Flavonoid Dimer FD18 Reverses P‑gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo by Yan, Clare S. W, Wong, Iris L. K, Chan, Kin-Fai, Kan, Jason W. Y, Chong, Tsz Cheung, Law, Man Chun, Zhao, Yunzhe, Chan, Shun Wan, Chan, Tak Hang, Chow, Larry M. C

“…Flavonoid dimer FD18 is a new class of dimeric P-gp modulator that can reverse cancer drug resistance. FD18 is a potent (EC50 = 148 nM for paclitaxel), safe…”
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Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel by Kan, Jason W Y, Yan, Clare S W, Wong, Iris L K, Su, Xiaochun, Liu, Zhen, Chan, Tak Hang, Chow, Larry M C

“…Biotransformation of flavonoid dimer FD18 resulted in an active metabolite FM04. It was more druggable because of its improved physicochemical properties. FM04…”
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Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)2, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2) by Chong, Tsz Cheung, Wong, Iris L. K., Cui, Jiahua, Law, Man Chun, Zhu, Xuezhen, Hu, Xuesen, Kan, Jason W. Y., Yan, Clare S. W., Chan, Tak Hang, Chow, Larry M. C.

“…Overexpression of breast cancer resistance transporter (BCRP/ABCG2) in cancers has been explained for the failure of chemotherapy in clinic. Inhibition of the…”
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Amine Linked Flavonoid Dimers as Modulators for P-Glycoprotein-Based Multidrug Resistance: Structure–Activity Relationship and Mechanism of Modulation by Chan, Kin-Fai, Wong, Iris L. K, Kan, Jason W. Y, Yan, Clare S. W, Chow, Larry M. C, Chan, Tak Hang

“…Here we report a great improvement in reversal potency of cancer drug resistance when flavonoid dimers possess a functionally substituted aminopolyethylene…”
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Identification of Binding Sites in the Nucleotide-Binding Domain of P‑Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04 by Liu, Zhen, Wong, Iris L. K., Sang, Jingcheng, Liu, Fufeng, Yan, Clare S. W., Kan, Jason W. Y., Chan, Tak Hang, Chow, Larry M. C.

“…We have previously discovered an amine-containing flavonoid monomer FM04 as a potent P-glycoprotein (P-gp) inhibitor (EC50 = 83 nM). Here, a series of…”
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Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor by Lui, Hok Kiu, Gao, Wei, Cheung, Kwan Choi, Jin, Wen Bin, Sun, Ning, Kan, Jason W.Y., Wong, Iris L.K., Chiou, Jiachi, Lin, Dachuan, Chan, Edward W.C., Leung, Yun-Chung, Chan, Tak Hang, Chen, Sheng, Chan, Kin-Fai, Wong, Kwok-Yin

“…The rapid emergence of methicillin-resistant Staphylococcus aureus (MRSA) strains has undermined the therapeutic efficacy of existing β-lactam antibiotics…”
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