Search Results - "Kan, Frederick W.K."

Hamster Oviductin Regulates Tyrosine Phosphorylation of Sperm Proteins During In Vitro Capacitation1 by Saccary, Laurelle, She, Yi-Min, Oko, Richard, Kan, Frederick W.K

“…Oviductin or OVGP1, also known as oviduct-specific glycoprotein, has been shown to enhance sperm capacitation in addition to its other beneficial effects on…”
Get full text

Endometrial Receptivity Defects and Impaired Implantation in Diabetic NOD Mice1 by Albaghdadi, Ahmad J.H, Kan, Frederick W.K

“…Implantation failure is a major hurdle to a successful pregnancy. The high rate of postimplantation fetal loss in nonobese diabetic (NOD) mice is believed to…”
Get full text

Prevention of Placental Insufficiency in the Type 2 Diabetic New-Zealand Obese Mice by Pre-Pregnancy Administration of Macrolide-Immunosuppressant Tacrolimus by Albaghdadi, Ahmad J.H, Hewitt, Melanie A, Gu, Shan-Shan, Kan, Frederick W.K

Get full text

Alterations in oviductal cilia morphology and reduced expression of axonemal dynein in diabetic NOD mice by Shorter, Stephanie L, Albaghdadi, Ahmad J.H, Kan, Frederick W.K

“…Highlights • Cilia and expression of DNAI2 were examined in oviducts of female NOD mice. • Oviductal cilia of diabetic NOD mice appeared to be reduced in…”
Get full text

Evidence for the Regulation of Glycosylation of Golden Hamster (Mesocricetus auratus) Oviductin During the Estrous Cycle by MCBRIDE, Deborah S, BOISVERT, Chantale, BLEAU, Gilles, KAN, Frederick W. K

“…The oviduct contributes to the reproductive environment by secreting various factors, including a family of glycoproteins termed oviductins. Although many…”
Get full text

Subcellular Distribution of ZP1, ZP2, and ZP3 Glycoproteins During Folliculogenesis and Demonstration of Their Topographical Disposition Within the Zona Matrix of Mouse Ovarian Oocytes by EL-MESTRAH, Majid, CASTLE, Philip E, BOROSSA, Girum, KAN, Frederick W. K

“…The zona pellucida (ZP) is an extracellular coat synthesized and secreted by the oocyte during follicular development and surrounding the plasma membrane of…”
Get full text

Detection of Nascent and/or Mature Forms of Oviductin in the Female Reproductive Tract and Post-ovulatory Oocytes by Use of a Polyclonal Antibody Against Recombinant Hamster Oviductin by McBride, Deborah S, Boisvert, Chantale, Bleau, Gilles, Kan, Frederick W.K

“…Oviductins belong to a family of glycoproteins that have been suggested to play several roles during the early processes of reproduction. Recently, a…”
Get full text

Extracellular vesicle mediated intercellular communication at the porcine maternal-fetal interface: A new paradigm for conceptus-endometrial cross-talk by Bidarimath, Mallikarjun, Khalaj, Kasra, Kridli, Rami T., Kan, Frederick W. K., Koti, Madhuri, Tayade, Chandrakant

“…Exosomes and microvesicles are extracellular vesicles released from cells and can contain lipids, miRNAs and proteins that affect cells at distant sites…”
Get full text

The fluid factor OVGP1 provides a significant oviductal microenvironment for the reproductive process in golden hamster by Yamatoya, Kenji, Kurosawa, Masaru, Hirose, Michiko, Miura, Yoshiki, Taka, Hikari, Nakano, Tomoyuki, Hasegawa, Akiko, Kagami, Kyosuke, Yoshitake, Hiroshi, Goto, Kaoru, Ueno, Takashi, Fujiwara, Hiroshi, Shinkai, Yoichi, Kan, Frederick W. K., Ogura, Atsuo, Araki, Yoshihiko

“…The mammalian oviductal lumen is a specialized chamber that provides an environment that strictly regulates fertilization and early embryogenesis, but the…”
Get full text

Human OVGP1 enhances tyrosine phosphorylation of proteins in the fibrous sheath involving AKAP3 and increases sperm-zona binding by Zhao, Yuewen, Kan, Frederick W. K.

“…Purpose To investigate if the recombinant human oviduct-specific glycoprotein (rHuOVGP1)–enhanced tyrosine-phosphorylated (pY) proteins are components of…”
Get full text

The role of oviduct-specific glycoprotein (OVGP1) in modulating biological functions of gametes and embryos by Zhao, Yuewen, Vanderkooi, Sydney, Kan, Frederick W. K.

“…Diverse lines of evidence indicate that the mammalian oviduct makes important contributions to the complex process of reproduction other than being simply a…”
Get full text

Therapeutic Potentials of Low-Dose Tacrolimus for Aberrant Endometrial Features in Polycystic Ovary Syndrome by Albaghdadi, Ahmad J H, Kan, Frederick W K

“…Polycystic ovary syndrome (PCOS) is a major anovulatory infertility affecting a great proportion of women of childbearing age and is associated with obesity,…”
Get full text

Low-Dose Tacrolimus Promotes the Migration and Invasion and Nitric Oxide Production in the Human-Derived First Trimester Extravillous Trophoblast Cells In Vitro by Albaghdadi, Ahmad J H, Coyle, Kassandra, Kan, Frederick W K

“…Placentation is one of the most important determinants for a successful pregnancy, and this is dependent on the process of trophoblast migration and invasion…”
Get full text

Recombinant human oviductin regulates protein tyrosine phosphorylation and acrosome reaction by Zhao, Yuewen, Yang, Xiaojing, Jia, Zongchao, Reid, Robert L, Leclerc, Pierre, Kan, Frederick W K

“…The mammalian oviduct synthesizes and secretes a major glycoprotein known as oviductin (OVGP1), which has been shown to interact with gametes and early…”
Get full text

Low-Dose Tacrolimus Prevents Dysregulated Peri-Conceptional Ovarian and Systemic Immune Cellular Homeostasis in Subjects with PCOS by Albaghdadi, Ahmad J. H., Feeley, Carolyn Ann, Kan, Frederick W. K.

“…Polycystic ovary syndrome (PCOS) is characterized by failure of ovulation and is associated with obesity and chronic inflammation. Recent evidence suggests…”
Get full text

Immunosuppression with tacrolimus improved implantation and rescued expression of uterine progesterone receptor and its co-regulators FKBP52 and PIASy at nidation in the obese and diabetic mice: Comparative studies with metformin by Albaghdadi, Ahmad J.H., Kan, Frederick W.K.

“…Diabesity is often associated with subfertility and recurrent miscarriages. Evidence links systemic and local uterine cytotoxicity to the pathogenesis of…”
Get full text

Regionalization and Redistribution of Membrane Phospholipids and Cholesterol in Mouse Spermatozoa during in Vitro Capacitation1 by Lin, Yan, Kan, Frederick W.K.

Get full text

Recombinant human OVGP1 increases intracellular calcium and further potentiates the effects of progesterone on human sperm by Vanderkooi, Sydney C., Zhao, Yuewen, Lima, Patricia D. A., Kan, Frederick W. K.

“…Purpose To investigate the effects of recombinant human oviduct–specific glycoprotein (rHuOVGP1) alone and in combination with progesterone (P4) on…”
Get full text

Recombinant hamster oviductin is biologically active and exerts positive effects on sperm functions and sperm-oocyte binding by Yang, Xiaojing, Zhao, Yuewen, Yang, Xiaolong, Kan, Frederick W K

“…Studies carried out in several mammalian species suggest that oviductin, also known as oviduct-specific glycoprotein or OVGP1, plays a key role in sperm…”
Get full text

Role of Egg Sulfolipidimmobilizing Protein 1 on Mouse Sperm-Egg Plasma Membrane Binding by AHNONKITPANIT, V, WHITE, D, SUWAJANAKORN, S, KAN, F. W. K, NAMKING, M, WELLS, G, KAMOLVARIN, N, TANPHAICHITR, N

“…We have shown that sperm sulfolipidimmobilizing protein 1 (SLIP1, molecular mass of 68 kDa), a sulfogalactosylglycerolipid (SGG)-binding protein, is…”
Get full text