Search Results - "Kan, Anita"

Human placental exosomes induce maternal systemic immune tolerance by reprogramming circulating monocytes by Bai, Kunfeng, Lee, Cheuk-Lun, Liu, Xiaofeng, Li, Jianlin, Cao, Dandan, Zhang, Li, Hu, Duanlin, Li, Hong, Hou, Yanqing, Xu, Yue, Kan, Anita S Y, Cheung, Ka-Wang, Ng, Ernest H Y, Yeung, William S B, Chiu, Philip C N

“…The maternal immune system needs to tolerate the semi-allogeneic fetus in pregnancy. The adaptation occurs locally at the maternal-fetal interface as well as…”
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Whole-genome array CGH evaluation for replacing prenatal karyotyping in Hong Kong by Kan, Anita S Y, Lau, Elizabeth T, Tang, W F, Chan, Sario S Y, Ding, Simon C K, Chan, Kelvin Y K, Lee, C P, Hui, Pui Wah, Chung, Brian H Y, Leung, K Y, Ma, Teresa, Leung, Wing C, Tang, Mary H Y

“…To evaluate the effectiveness of whole-genome array comparative genomic hybridization (aCGH) in prenatal diagnosis in Hong Kong. Array CGH was performed on 220…”
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Biallelic TMEM260 variants cause truncus arteriosus, with or without renal defects by Pagnamenta, Alistair T., Jackson, Adam, Perveen, Rahat, Beaman, Glenda, Petts, Gemma, Gupta, Asheeta, Hyder, Zerin, Chung, Brian Hon‐Yin, Kan, Anita Sik‐Yau, Cheung, Ka Wang, Kerstjens‐Frederikse, Wilhelmina S., Abbott, Kristin M., Elpeleg, Orly, Taylor, Jenny C., Banka, Siddharth, Ta‐Shma, Asaf

“…Only two families have been reported with biallelic TMEM260 variants segregating with structural heart defects and renal anomalies syndrome (SHDRA). With a…”
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Revealing parental mosaicism: the hidden answer to the recurrence of apparent de novo variants by Lee, Mianne, Lui, Adrian C. Y., Chan, Joshua C. K., Doong, Phoenix H. L., Kwong, Anna K. Y., Mak, Christopher C. Y., Li, Raymond H. W., Kan, Anita S. Y., Chung, Brian H. Y.

“…Abstract Mosaicism refers to the presence of two or more populations of genetically distinct cells within an individual, all of which originate from a single…”
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Clinical and molecular characteristics of hemophilia A affected individuals and carriers: A 24 years experience from three centers by Ho, Stephanie K. L., Ng, Samuel Y. L., Yung, Tsz‐Kwai, Mok, Myth T. S., Yiu, Wing‐Chung, Cheng, Heidi H. Y., Cheng, Shirley S. W., Luk, Ho‐ming, Lo, Ivan F. M., Kan, Anita S. Y.

“…Hemophilia A is a rare bleeding disorder with variable expressivity and allelic heterogeneity. Despite the advancement of prenatal diagnostics and molecular…”
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Prenatal diagnosis of Myhre syndrome with a heterozygous pathogenic variant in SMAD4 gene presented with thick nuchal translucency and cardiac abnormalities by Hui, Pui Wah, Mok, Yin Kwan, Luk, Ho Ming, Au, Sandy Leung Kuen, Lau, Eunice Yuen Ting, Chung, Brian, Kan, Anita Sik Yau

“…Prenatal testing was performed in a 39-year-old Chinese pregnant woman referred for increased nuchal translucency measuring 5.7 mm. Non-invasive prenatal…”
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Prenatal and postnatal diagnosis of Schuurs‐Hoeijmakers syndrome: Case series and review of the literature by Seto, Mimi Tin‐Yan, Bertoli‐Avella, Aida M., Cheung, Ka Wang, Chan, Kelvin Yuen‐Kwong, Yeung, Kit San, Fung, Jasmine Lee‐Fong, Beetz, Christian, Bauer, Peter, Luk, Ho Ming, Lo, Ivan Fai‐Man, Lee, Chin Peng, Chung, Brian Hon‐Yin, Kan, Anita Sik‐Yau

“…Schuurs‐Hoeijmakers syndrome (SHS) is a rare syndrome involving a de novo variant in the PACS1 gene on chromosome 11q13. There are 36 individuals published in…”
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Experience of chromosomal microarray applied in prenatal and postnatal settings in Hong Kong by Cheng, Shirley S. W., Chan, Kelvin Y. K., Leung, Kelphen K. P., Au, Patrick K. C., Tam, Wai‐Keung, Li, Samuel K. M., Luk, Ho‐Ming, Kan, Anita S. Y., Chung, Brian H. Y., Lo, Ivan F. M., Tang, Mary H. Y.

“…Chromosomal microarray (CMA) is recommended as a first tier investigation for patients with developmental delay (DD), intellectual disability (ID), autistic…”
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The clinical impact of chromosomal microarray on paediatric care in Hong Kong by Tao, Victoria Q, Chan, Kelvin Y K, Chu, Yoyo W Y, Mok, Gary T K, Tan, Tiong Y, Yang, Wanling, Lee, So Lun, Tang, Wing Fai, Tso, Winnie W Y, Lau, Elizabeth T, Kan, Anita S Y, Tang, Mary H, Lau, Yu-Lung, Chung, Brian H Y

“…To evaluate the clinical impact of chromosomal microarray (CMA) on the management of paediatric patients in Hong Kong. We performed NimbleGen 135k…”
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Prenatal diagnosis of 5p deletion syndrome: Report of five cases by Mak, Annisa S. L., Ma, Teresa W. L., Chan, Kelvin Y. K., Kan, Anita S. Y., Tang, Mary H. Y., Leung, Kwok Y.

“…It is difficult to prenatally identify 5p deletion (−) syndrome. Here, we report five cases of 5p‐ syndrome diagnosed by invasive prenatal diagnosis. Of them,…”
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Optimal timing of hepatitis B virus DNA quantification and clinical predictors for higher viral load during pregnancy by Cheung, Ka W, Seto, Mimi T Y, So, Po L, Wong, Daniel, Mak, Annisa S L, Lau, Wai L, Wang, Weilan, Kan, Anita S Y, Lee, Chin P, Ng, Ernest H Y

“…Authorities publish recommendations on the hepatitis B virus (HBV) viral load threshold to initiate antiviral treatment but the timing of quantification during…”
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Diagnostic potential of the amniotic fluid cells transcriptome in deciphering mendelian disease: a proof-of-concept by Lee, Mianne, Kwong, Anna K. Y., Chui, Martin M. C., Chau, Jeffrey F. T., Mak, Christopher C. Y., Au, Sandy L. K., Lo, Hei Man, Chan, Kelvin Y. K., Yépez, Vicente A., Gagneur, Julien, Kan, Anita S. Y., Chung, Brian H. Y.

“…RNA sequencing (RNA-seq) is emerging in genetic diagnoses as it provides functional support for the interpretation of variants of uncertain significance…”
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Dysregulation of the CD147 complex confers defective placental development: A pathogenesis of early‐onset preeclampsia by Lee, Cheuk‐Lun, Chen, Zhilong, Zhang, Qingqing, Guo, Yue, Ng, Vivian W.Y., Zhang, Baozhen, Bai, Kunfeng, Ruan, Degong, Kan, Anita S.Y., Cheung, Ka‐Wang, Mak, Annisa S.L., Yeung, William S.B., Su, Rui, Yang, Qing, Chen, Min, Du, Mei‐Rong, Jian, Zhang, Fan, Xiujun, Chiu, Philip C.N.

“…PE is a multifactorial gestational complication affecting 4.6% of pregnancies worldwide.1 It is the top cause of prenatal morbidity/mortality and is associated…”
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Prenatal presentation in two fetuses with features of Beckwith Wiedemann syndrome—An unexpected diagnosis of androgenetic chimera and its clinical implications by Yu, Pui‐Tak, Shu, Wendy, Mok, Sau‐Lan, Hui, Pui‐Wah, Chan, Lin‐Wai, Kwok, Ka‐Yin, Chan, Kelvin Y. K., Lo, Tsz‐Kin, Chung, Brian H. Y., Luk, Ho‐Ming, Kan, Anita S. Y.

“…Beckwith Wiedemann Syndrome (BWS, OMIM 130650) is an imprinting disorder that may present antenatally with a constellation of sonographic features namely…”
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Increasing prenatal diagnosis of chimeras with the use of noninvasive prenatal screening: Report of two cases by Yu, Florrie N. Y., Li, Elizabeth Y. Y., Kong, Meliza C. W., Ma, Teresa W. L., Chan, Kelvin Y. K., Man, Elim, Chung, Brian H. Y., Kan, Anita S. Y.

“…Bulleted Statements: What's already known about this topic? The incidence of discordant fetal sex was estimated to be 1 in 1500–2000. Comprehensive evaluation…”
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Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia by Zhang, Qingqing, Lee, Cheuk-Lun, Yang, Tingyu, Li, Jianlin, Zeng, Qunxiong, Liu, Xiaofeng, Liu, Zhongzhen, Ruan, Degong, Li, Zhuoxuan, Kan, Anita S Y, Cheung, Ka-Wang, Mak, Annisa S L, Ng, Vivian W Y, Zhao, Huashan, Fan, Xiujun, Duan, Yong-Gang, Zhong, Liuying, Chen, Min, Du, Meirong, Li, Raymond H W, Liu, Pengtao, Ng, Ernest H Y, Yeung, William S B, Gao, Ya, Yao, Yuanqing, Chiu, Philip C N

“…Early-onset preeclampsia (EOPE) is a severe pregnancy complication associated with defective trophoblast differentiation and functions at implantation, but…”
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Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES) by Leung, Gordon K C, Mak, Christopher C Y, Fung, Jasmine L F, Wong, Wilfred H S, Tsang, Mandy H Y, Yu, Mullin H C, Pei, Steven L C, Yeung, K S, Mok, Gary T K, Lee, C P, Hui, Amelia P W, Tang, Mary H Y, Chan, Kelvin Y K, Liu, Anthony P Y, Yang, Wanling, Sham, P C, Kan, Anita S Y, Chung, Brian H Y

“…Whole-exome sequencing (WES) has become an invaluable tool for genetic diagnosis in paediatrics. However, it has not been widely adopted in the prenatal…”
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Expanded Carrier Screening in Chinese Population - A Survey on Views and Acceptance of Pregnant and Non-Pregnant Women by Cheng, Hiu Yee Heidi, Wong, Grace Ching Yin, Chan, Yuen-Kwong Kelvin, Lee, Chin Peng, Tang, Mary Hoi Yin, Ng, Ernest Hung-Yu, Kan, Anita Sik-Yau

“…Recessive genetic diseases impose physical and psychological impacts to both newborns and parents who may not be aware of being carriers. Expanded carrier…”
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Decision outcomes in women offered noninvasive prenatal test (NIPT) for positive Down screening results by Lo, Tsz-Kin, Chan, Kelvin Yuen-Kwong, Kan, Anita Sik-Yau, So, Po-Lam, Kong, Choi-Wah, Mak, Shui-Lam, Lee, Chung-Nin

“…In this first Asian study, the decision outcomes (decision conflict, decision regret, and anxiety) of 262 pregnant women offered noninvasive prenatal test…”
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Antenatal counselling of congenital surgical anomalies: A decade of experience in a local tertiary centre by Fung, Adrian Chi Heng, Kan, Anita Sik Yau, Chung, Patrick HY, Shek, Noel Wing Man, Chan, Ivy Hau Yee, Wong, Kenneth Kak Yuen

“…Aim This study reviewed the experience of a tertiary paediatric surgery and obstetric centre on prenatal counselling of congenital surgical anomalies and to…”
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