Search Results - "Kampen, R L"

Molecular Evaluation of BK Polyomavirus Nephropathy by Mannon, R. B., Hoffmann, S. C., Kampen, R. L., Cheng, O. C., Kleiner, D. E., Ryschkewitsch, C., Curfman, B., Major, E., Hale, D. A., Kirk, A. D.

“…Understanding at a molecular level, the immunologic response of polyomavirus nephropathy (PVN), a critical cause of kidney graft loss, could lead to new…”
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Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (Campath-1H) by KIRK, Allan D, HALE, Douglas A, MANNON, Roslyn B, KLEINER, David E, HOFFMANN, Steven C, KAMPEN, Robert L, CENDALES, Linda K, TADAKI, Douglas K, HARLAN, David M, SWANSON, S. John

“…Profound T-cell depletion before allotransplantation with gradual posttransplant T-cell repopulation induces a state of donor-specific immune…”
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Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin by KIRK, Allan D, MANNON, Roslyn B, HALE, Douglas A, KLEINER, David E, SWANSON, John S, KAMPEN, Robert L, CENDALES, Linda K, ELSTER, Eric A, WAKEFIELD, Terri, CHAMBERLAIN, Christine, HOFFMANN, Steven C

“…Perioperative lymphocyte depletion induces allograft tolerance in some animal models, but in humans has only been shown to reduce immunosuppressive…”
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Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates by Kirk, Allan D, Burkly, Linda C, Batty, D. Scott, Baumgartner, Roxanne E, Berning, Justin D, Buchanan, Kelvin, Fechner, John H, Germond, Rhonda L, Kampen, Robert L, Patterson, Noelle B, Swanson, S. John, Tadaki, Douglas K, TenHoor, Christopher N, White, Leonard, Knechtle, Stuart J, Harlan, David M

“…CD154 is the ligand for the receptor CD40. This ligand-receptor pair mediates endothelial and antigen-presenting cell activation, and facilitates the…”
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Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury by HOFFMANN, Steven C, KAMPEN, Robert L, KIRK, Allan D, AMUR, Shashi, SHARAF, Muhammad A, KLEINER, David E, HUNTER, Keith, SWANSON, S. John, HALE, Douglas A, MANNON, Roslyn B, BLAIR, Patrick J

“…BACKGROUND Following allotransplantation, renal ischemia-reperfusion (I/R) injury initiates a series of events that provokes counter-adaptive immunity. Though…”
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Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates by Kirk, A D, Tadaki, D K, Celniker, A, Batty, D S, Berning, J D, Colonna, J O, Cruzata, F, Elster, E A, Gray, G S, Kampen, R L, Patterson, N B, Szklut, P, Swanson, J, Xu, H, Harlan, D M

“…CD80 and CD86 (also known as B7-1 and B7-2, respectively) are both ligands for the T cell costimulatory receptors CD28 and CD152. Both CD80 and CD86 mediate T…”
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Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation by MONTGOMERY, Sean P, HE XU, SWANSON, S. John, HARLAN, David M, KIRK, Allan D, TADAKI, Douglas K, CELNIKER, Abbie, BURKLY, Linda C, BERNING, Justin D, CRUZATA, Francis, ELSTER, Eric A, GRAY, Gary, KAMPEN, Robert L

“…Antibodies and fusion proteins specific for CD80, CD86, and CD154 have shown promise as agents capable of inducing donor-specific tolerance in rodents. These…”
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Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates by HE XU, TADAKI, Douglas K, KIRK, Allan D, ELSTER, Eric A, BURKLY, Linda C, BERNING, Justin D, CRUZATA, Francis, KAMPEN, Robert L, MONTGOMERY, Sean P, PATTERSON, Noelle B, HARLAN, David M

“…The anti-CD154 antibody hu5C8 prevents acute allograft rejection and prolongs allograft survival after withdrawal of therapy in nonhuman primates. This study…”
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Human Renal Allograft Rejection Despite the Absence of Allogeneic Passenger Leukocytes by Preston, Edwin H., Light, Jimmy A., Kampen, Robert L., Kirk, Allan D.

“…Passenger leukocytes have been suggested to be both pro‐tolerant and immunogenic. The opportunity to evaluate the role of allogeneic passenger leukocytes in…”
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Effect of Alemtuzumab (CAMPATH 1-H) in patients with inclusion-body myositis by Dalakas, Marinos C., Rakocevic, Goran, Schmidt, Jens, Salajegheh, Mohammad, McElroy, Beverly, Harris-Love, Michael O., Shrader, Joseph A., Levy, Ellen W., Dambrosia, James, Kampen, Robert L., Bruno, David A., Kirk, Allan D.

“…Sporadic inclusion-body myositis (sIBM) is the most common disabling, adult-onset, inflammatory myopathy histologically characterized by intense inflammation…”
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A comparative study of the cell cycle status and primitive cell adhesion molecule profile of human CD34 + cells cultured in stroma-free versus porcine microvascular endothelial cell cultures by Chute, John P, Saini, Abha A, Kampen, Robert L, Wells, Mark R, Davis, Thomas A

“…Porcine microvascular endothelial cells (PMVECs) plus cytokines support a rapid proliferation and expansion of human CD34 +CD38 − cells that are capable of…”
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Functionally Significant Renal Allograft Rejection Is Defined by Transcriptional Criteria by Hoffmann, Steven C., Hale, Douglas A., Kleiner, David E., Mannon, Roslyn B., Kampen, Robert L., Jacobson, Lynn M., Cendales, Linda C., Swanson, S. John, Becker, Bryan N., Kirk, Allan D.

“…Renal allograft acute cellular rejection (ACR) is a T‐cell mediated disease that is diagnosed histologically. However, many normally functioning allografts…”
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Disruption of CD40/CD40-Ligand Interactions in a Retinal Autoimmunity Model Results in Protection without Tolerance by Bagenstose, Lee M, Agarwal, Rajeev K, Silver, Phyllis B, Harlan, David M, Hoffmann, Steven C, Kampen, Robert L, Chan, Chi-Chao, Caspi, Rachel R

“…We examined the role of CD40/CD40L interactions on the development of experimental autoimmune uveoretinitis (EAU), a cell-mediated, Th1-driven autoimmune…”
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