Search Results - "Kampen, Kim"

Hallmarks of ribosomopathies by Kampen, Kim R, Sulima, Sergey O, Vereecke, Stijn, De Keersmaecker, Kim

“…Abstract Ribosomopathies are diseases caused by defects in ribosomal constituents or in factors with a role in ribosome assembly. Intriguingly, congenital…”
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The DMT1 isoform lacking the iron‐response element regulates normal and malignant hematopoiesis via NOTCH pathway activation by Hounjet, Judith, Van Aerschot, Linde, De Keersmaecker, Kim, Vooijs, Marc, Kampen, Kim R.

“…Natural resistance‐associated macrophage protein 2 (NRAMP 2; also known as DMT1 and encoded by SLC11A2) is mainly known for its iron transport activity…”
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The ins and outs of serine and glycine metabolism in cancer by Geeraerts, Shauni L., Heylen, Elien, De Keersmaecker, Kim, Kampen, Kim R.

“…Cancer cells reprogramme their metabolism to support unrestrained proliferation and survival in nutrient-poor conditions. Whereas non-transformed cells often…”
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Membrane Proteins: The Key Players of a Cancer Cell by Kampen, Kim R.

“…Membrane proteins are involved in the prognosis of the most common forms of cancer. Membrane proteins are the hallmark of a cancer cell. The overexpressed…”
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Cancer Biogenesis in Ribosomopathies by Sulima, Sergey O, Kampen, Kim R, De Keersmaecker, Kim

“…Ribosomopathies are congenital diseases with defects in ribosome assembly and are characterized by elevated cancer risks. Additionally, somatic mutations in…”
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The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types by Fancello, Laura, Kampen, Kim R, Hofman, Isabel J F, Verbeeck, Jelle, De Keersmaecker, Kim

“…For many years, defects in the ribosome have been associated to cancer. Recently, somatic mutations and deletions affecting ribosomal protein genes were…”
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Linking Serine/Glycine Metabolism to Radiotherapy Resistance by Sánchez-Castillo, Anaís, Vooijs, Marc, Kampen, Kim R

“…The activation of de novo serine/glycine biosynthesis in a subset of tumors has been described as a major contributor to tumor pathogenesis, poor outcome, and…”
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Understanding serine and glycine metabolism in cancer: a path towards precision medicine to improve patient’s outcomes by Sánchez-Castillo, Anaís, Kampen, Kim R.

“…In this perspective, we highlight and reflect on the current knowledge with respect to serine/glycine metabolism in cancer, therapeutic resistance, and…”
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The discovery and early understanding of leukemia by Kampen, Kim R

“…Abstract The early history of leukemia reaches back 200 years. In 1811, Peter Cullen defined a case of splenitis acutus with unexplainable milky blood. Alfred…”
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Ribosomal Lesions Promote Oncogenic Mutagenesis by Sulima, Sergey O, Kampen, Kim R, Vereecke, Stijn, Pepe, Daniele, Fancello, Laura, Verbeeck, Jelle, Dinman, Jonathan D, De Keersmaecker, Kim

“…Ribosomopathies are congenital disorders caused by mutations in ribosomal proteins (RP) or assembly factors and are characterized by cellular hypoproliferation…”
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Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells by Kampen, Kim R., Fancello, Laura, Girardi, Tiziana, Rinaldi, Gianmarco, Planque, Mélanie, Sulima, Sergey O., Loayza-Puch, Fabricio, Verbelen, Benno, Vereecke, Stijn, Verbeeck, Jelle, Op de Beeck, Joyce, Royaert, Jonathan, Vermeersch, Pieter, Cassiman, David, Cools, Jan, Agami, Reuven, Fiers, Mark, Fendt, Sarah-Maria, De Keersmaecker, Kim

“…Somatic ribosomal protein mutations have recently been described in cancer, yet their impact on cellular transcription and translation remains poorly…”
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The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL by Kampen, Kim R., Sulima, Sergey O., Verbelen, Benno, Girardi, Tiziana, Vereecke, Stijn, Rinaldi, Gianmarco, Verbeeck, Jelle, Op de Beeck, Joyce, Uyttebroeck, Anne, Meijerink, Jules P. P., Moorman, Anthony V., Harrison, Christine J., Spincemaille, Pieter, Cools, Jan, Cassiman, David, Fendt, Sarah-Maria, Vermeersch, Pieter, De Keersmaecker, Kim

“…The R98S mutation in ribosomal protein L10 (RPL10 R98S) affects 8% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) cases, and was previously described…”
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Transcription factor NKX2–1 drives serine and glycine synthesis addiction in cancer by Heylen, Elien, Verstraete, Paulien, Van Aerschot, Linde, Geeraerts, Shauni L., Venken, Tom, Timcheva, Kalina, Nittner, David, Verbeeck, Jelle, Royaert, Jonathan, Gijbels, Marion, Uyttebroeck, Anne, Segers, Heidi, Lambrechts, Diether, Cools, Jan, De Keersmaecker, Kim, Kampen, Kim R.

“…Background One-third of cancers activate endogenous synthesis of serine/glycine, and can become addicted to this pathway to sustain proliferation and survival…”
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Iron‐responsive element of Divalent metal transporter 1 (Dmt1) controls Notch‐mediated cell fates by Hounjet, Judith, Groot, Arjan J., Piepers, Jolanda P., Kranenburg, Onno, Zwijnenburg, Danny A., Rapino, Francesca A., Koster, Jan B., Kampen, Kim R., Vooijs, Marc A.

“…Notch receptor activation is regulated by the intramembrane protease γ‐secretase, which cleaves and liberates the Notch intracellular domain (Nicd) that…”
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Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer by Sánchez-Castillo, Anaís, Heylen, Elien, Hounjet, Judith, Savelkouls, Kim G., Lieuwes, Natasja G., Biemans, Rianne, Dubois, Ludwig J., Reynders, Kobe, Rouschop, Kasper M., Vaes, Rianne D. W., De Keersmaecker, Kim, Lambrecht, Maarten, Hendriks, Lizza E. L., De Ruysscher, Dirk K. M., Vooijs, Marc, Kampen, Kim R.

“…Background Lung cancer is the most lethal cancer, and 85% of cases are classified as non-small cell lung cancer (NSCLC). Metabolic rewiring is a cancer…”
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Vascular endothelial growth factor signaling in acute myeloid leukemia by Kampen, Kim R., ter Elst, Arja, de Bont, Eveline S. J. M.

“…This review is designed to provide an overview of the current literature concerning vascular endothelial growth factor signaling (VEGF) in acute myeloid…”
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Correction: Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer by Sánchez-Castillo, Anaís, Heylen, Elien, Hounjet, Judith, Savelkouls, Kim G., Lieuwes, Natasja G., Biemans, Rianne, Dubois, Ludwig J., Reynders, Kobe, Rouschop, Kasper M., Vaes, Rianne D. W., De Keersmaecker, Kim, Lambrecht, Maarten, Hendriks, Lizza E. L., De Ruysscher, Dirk K. M., Vooijs, Marc, Kampen, Kim R.

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Growth-factor-driven rescue to receptor tyrosine kinase (RTK) inhibitors through Akt and Erk phosphorylation in pediatric low grade astrocytoma and ependymoma by Sie, Mariska, den Dunnen, Wilfred F A, Lourens, Harm Jan, Meeuwsen-de Boer, Tiny G J, Scherpen, Frank J G, Zomerman, Walderik W, Kampen, Kim R, Hoving, Eelco W, de Bont, Eveline S J M

“…Up to now, several clinical studies have been started investigating the relevance of receptor tyrosine kinase (RTK) inhibitors upon progression free survival…”
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Rise of the specialized onco-ribosomes by Kampen, Kim R, Sulima, Sergey O, De Keersmaecker, Kim

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Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas by Sánchez-Castillo, Anaís, Savelkouls, Kim G., Baldini, Alessandra, Hounjet, Judith, Sonveaux, Pierre, Verstraete, Paulien, De Keersmaecker, Kim, Dewaele, Barbara, Björkblom, Benny, Melin, Beatrice, Wu, Wendy Y., Sjöberg, Rickard L., Rouschop, Kasper M. A., Broen, Martijn P. G., Vooijs, Marc, Kampen, Kim R.

“…The serine/glycine (ser/gly) synthesis pathway branches from glycolysis and is hyperactivated in approximately 30% of cancers. In ~13% of glioblastoma cases,…”
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