Search Results - "Kamp, David W."

Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways by Suryadevara, Vidyani, Ramchandran, Ramaswamy, Kamp, David W, Natarajan, Viswanathan

“…Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown etiology characterized by distorted distal lung architecture, inflammation, and…”
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Molecular basis of asbestos-induced lung disease by Liu, Gang, Cheresh, Paul, Kamp, David W

“…Asbestos causes asbestosis and malignancies by molecular mechanisms that are not fully understood. The modes of action underlying asbestosis, lung cancer, and…”
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Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts by Huang, Long Shuang, Sudhadevi, Tara, Fu, Panfeng, Punathil-Kannan, Prasanth-Kumar, Ebenezer, David Lenin, Ramchandran, Ramaswamy, Putherickal, Vijay, Cheresh, Paul, Zhou, Guofei, Ha, Alison W, Harijith, Anantha, Kamp, David W, Natarajan, Viswanathan

“…The sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) signaling axis is emerging as a key player in the development of idiopathic pulmonary fibrosis…”
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Pro-inflammatory response and oxidative stress induced by specific components in ambient particulate matter in human bronchial epithelial cells by Yang, Lawei, Liu, Gang, Lin, Ziying, Wang, Yahong, He, Huijuan, Liu, Tie, Kamp, David W.

“…ABSTRACT Previous studies have shown that biological effect of particulate matter (PM2.5) is involved in including chemical composition and mass concentration,…”
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SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis by Akamata, Kaname, Wei, Jun, Bhattacharyya, Mitra, Cheresh, Paul, Bonner, Michael Y, Arbiser, Jack L, Raparia, Kirtee, Gupta, Mahesh P, Kamp, David W, Varga, John

“…Constitutive fibroblast activation is responsible for organ fibrosis in fibrotic disorders including systemic sclerosis (SSc), but the underlying mechanisms…”
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SIRT3 Overexpression Ameliorates Asbestos-Induced Pulmonary Fibrosis, mt-DNA Damage, and Lung Fibrogenic Monocyte Recruitment by Cheresh, Paul, Kim, Seok-Jo, Jablonski, Renea, Watanabe, Satoshi, Lu, Ziyan, Chi, Monica, Helmin, Kathryn A, Gius, David, Budinger, G R Scott, Kamp, David W

“…Alveolar epithelial cell (AEC) mitochondrial (mt) DNA damage and fibrotic monocyte-derived alveolar macrophages (Mo-AMs) are implicated in the pathobiology of…”
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The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis by Kim, Seok-Jo, Cheresh, Paul, Jablonski, Renea P, Williams, David B, Kamp, David W

“…Convincing evidence has emerged demonstrating that impairment of mitochondrial function is critically important in regulating alveolar epithelial cell (AEC)…”
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Mitochondria-targeted Ogg1 and Aconitase-2 Prevent Oxidant-induced Mitochondrial DNA Damage in Alveolar Epithelial Cells by Kim, Seok-Jo, Cheresh, Paul, Williams, David, Cheng, Yuan, Ridge, Karen, Schumacker, Paul T., Weitzman, Sigmund, Bohr, Vilhelm A., Kamp, David W.

“…Mitochondria-targeted human 8-oxoguanine DNA glycosylase (mt-hOgg1) and aconitase-2 (Aco-2) each reduce oxidant-induced alveolar epithelial cell (AEC)…”
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miR-5100 promotes tumor growth in lung cancer by targeting Rab6 by Huang, Haili, Jiang, Yun, Wang, Yahong, Chen, Ting, Yang, Lawei, He, Huijuan, Lin, Ziying, Liu, Tie, Yang, Teng, Kamp, David W, Wu, Bin, Liu, Gang

“…Highlights • Exogenous expression of miR-5100 promotes tumor growth in vitro and in vivo. • Exogenous expression of miR-5100 promotes G1/S transition. • Rab6…”
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Long Noncoding RNA FENDRR Inhibits Lung Fibroblast Proliferation via a Reduction of β-Catenin by Senavirathna, Lakmini Kumari, Liang, Yurong, Huang, Chaoqun, Yang, Xiaoyun, Bamunuarachchi, Gayan, Xu, Dao, Dang, Quanjin, Sivasami, Pulavendran, Vaddadi, Kishore, Munteanu, Maria Cristina, Hewawasam, Sankha, Cheresh, Paul, Kamp, David W., Liu, Lin

“…Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, and usually lethal lung disease and it has been widely accepted that fibroblast proliferation is…”
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Asbestos-induced alveolar epithelial cell apoptosis. The role of endoplasmic reticulum stress response by Kamp, David W, Liu, Gang, Cheresh, Paul, Kim, Seok-Jo, Mueller, Amanda, Lam, Anna P, Trejo, Humberto, Williams, David, Tulasiram, Sandhya, Baker, Margaret, Ridge, Karen, Chandel, Navdeep S, Beri, Rohinee

“…Asbestos exposure results in pulmonary fibrosis (asbestosis) and malignancies (bronchogenic lung cancer and mesothelioma) by mechanisms that are not fully…”
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Role of Mutagenicity in Asbestos Fiber-Induced Carcinogenicity and Other Diseases by Huang, Sarah X. L., Jaurand, Marie-Claude, Kamp, David W., Whysner, John, Hei, Tom K.

“…The cellular and molecular mechanisms of how asbestos fibers induce cancers and other diseases are not well understood. Both serpentine and amphibole asbestos…”
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The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes by Cheresh, Paul, Kim, Seok-Jo, Huang, Long Shuang, Watanabe, Satoshi, Joshi, Nikita, Williams, Kinola J N, Chi, Monica, Lu, Ziyan, Harijith, Anantha, Yeldandi, Anjana, Lam, Anna P, Gottardi, Cara, Misharin, Alexander V, Budinger, G R Scott, Natarajan, Viswanathan, Kamp, David W

“…Idiopathic pulmonary fibrosis (IPF) is a chronic disease for which novel approaches are urgently required. We reported increased sphingosine kinase 1 (SPHK1)…”
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Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice by Cheresh, Paul, Morales-Nebreda, Luisa, Kim, Seok-Jo, Yeldandi, Anjana, Williams, David B, Cheng, Yuan, Mutlu, Gökhan M, Budinger, G R Scott, Ridge, Karen, Schumacker, Paul T, Bohr, Vilhelm A, Kamp, David W

“…Asbestos causes asbestosis and malignancies by mechanisms that are not fully established. Alveolar epithelial cell (AEC) injury and repair are crucial…”
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Mitochondrial Complex III-generated Oxidants Activate ASK1 and JNK to Induce Alveolar Epithelial Cell Death following Exposure to Particulate Matter Air Pollution by Soberanes, Saul, Urich, Daniela, Baker, Christina M., Burgess, Zach, Chiarella, Sergio E., Bell, Eric L., Ghio, Andrew J., De Vizcaya-Ruiz, Andrea, Liu, Jing, Ridge, Karen M., Kamp, David W., Chandel, Navdeep S., Schumacker, Paul T., Mutlu, Gökhan M., Budinger, G.R. Scott

“…We have previously reported that airborne particulate matter air pollution (PM) activates the intrinsic apoptotic pathway in alveolar epithelial cells through…”
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Oxidative stress and pulmonary fibrosis by Cheresh, Paul, Kim, Seok-Jo, Tulasiram, Sandhya, Kamp, David W.

“…Oxidative stress is implicated as an important molecular mechanism underlying fibrosis in a variety of organs, including the lungs. However, the causal role of…”
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Asbestos-induced lung diseases: an update by Kamp, David W

“…Asbestos causes asbestosis (pulmonary fibrosis caused by asbestos inhalation) and malignancies (bronchogenic carcinoma and mesothelioma) by mechanisms that are…”
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p53 Mediates Particulate Matter-induced Alveolar Epithelial Cell Mitochondria-regulated Apoptosis by Soberanes, Saul, Panduri, Vijayalakshmi, Mutlu, Gokhan M, Ghio, Andrew, Bundinger, G. R. Scott, Kamp, David W

“…Exposure to particulate matter (PM) causes lung cancer by mechanisms that are unknown, but p53 dysfunction is implicated. We determined whether p53 is required…”
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Mitigating Lung Fibrosis by Targeting Dysfunctional Alveolar Epithelial Cell Lipid Metabolism by Kamp, David W

“…Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, age-related, and fatal lung disease with a median survival of 3-5 years. Although two drugs…”
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Mitochondrial-derived free radicals mediate asbestos-induced alveolar epithelial cell apoptosis by Panduri, Vijayalakshmi, Weitzman, Sigmund A, Chandel, Navdeep S, Kamp, David W

“…Asbestos causes pulmonary toxicity by mechanisms that in part involve reactive oxygen species (ROS). However, the precise source of ROS is unclear. We showed…”
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