Search Results - "Kammoun, Helene L."

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice by Kammoun, Hélène L, Chabanon, Hervé, Hainault, Isabelle, Luquet, Serge, Magnan, Christophe, Koike, Tatsuro, Ferré, Pascal, Foufelle, Fabienne

“…Hepatic steatosis is present in insulin-resistant obese rodents and is concomitant with active lipogenesis. Hepatic lipogenesis depends on the insulin-induced…”
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Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function? by Kraakman, Michael James, Murphy, Andrew James, Jandeleit-Dahm, Karin, Kammoun, Hélène L

“…Obesity and type 2 diabetes are now recognized as chronic pro-inflammatory diseases. In the last decade, the role of the macrophage in particular has become…”
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IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome by Murphy, Andrew J., Kraakman, Michael J., Kammoun, Helene L., Dragoljevic, Dragana, Lee, Man K.S., Lawlor, Kate E., Wentworth, John M., Vasanthakumar, Ajithkumar, Gerlic, Motti, Whitehead, Lachlan W., DiRago, Ladina, Cengia, Louise, Lane, Rachael M., Metcalf, Donald, Vince, James E., Harrison, Leonard C., Kallies, Axel, Kile, Benjamin T., Croker, Ben A., Febbraio, Mark A., Masters, Seth L.

“…Interleukin-18 (IL-18) is activated by Caspase-1 in inflammasome complexes and has anti-obesity effects; however, it is not known which inflammasome regulates…”
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Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors by Haeusler, Rebecca A., Hartil, Kirsten, Vaitheesvaran, Bhavapriya, Arrieta-Cruz, Isabel, Knight, Colette M., Cook, Joshua R., Kammoun, Helene L., Febbraio, Mark A., Gutierrez-Juarez, Roger, Kurland, Irwin J., Accili, Domenico

“…Insulin integrates hepatic glucose and lipid metabolism, directing nutrients to storage as glycogen and triglyceride. In type 2 diabetes, levels of the former…”
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Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes by Kraakman, Michael J, Lee, Man Ks, Al-Sharea, Annas, Dragoljevic, Dragana, Barrett, Tessa J, Montenont, Emilie, Basu, Debapriya, Heywood, Sarah, Kammoun, Helene L, Flynn, Michelle, Whillas, Alexandra, Hanssen, Nordin Mj, Febbraio, Mark A, Westein, Erik, Fisher, Edward A, Chin-Dusting, Jaye, Cooper, Mark E, Berger, Jeffrey S, Goldberg, Ira J, Nagareddy, Prabhakara R, Murphy, Andrew J

“…Platelets play a critical role in atherogenesis and thrombosis-mediated myocardial ischemia, processes that are accelerated in diabetes. Whether hyperglycemia…”
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Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance by Kraakman, Michael J., Kammoun, Helene L., Allen, Tamara L., Deswaerte, Virginie, Henstridge, Darren C., Estevez, Emma, Matthews, Vance B., Neill, Bronwyn, White, David A., Murphy, Andrew J., Peijs, Lone, Yang, Christine, Risis, Steve, Bruce, Clinton R., Du, Xiao-Jun, Bobik, Alex, Lee-Young, Robert S., Kingwell, Bronwyn A., Vasanthakumar, Ajithkumar, Shi, Wei, Kallies, Axel, Lancaster, Graeme I., Rose-John, Stefan, Febbraio, Mark A.

“…Interleukin-6 (IL-6) plays a paradoxical role in inflammation and metabolism. The pro-inflammatory effects of IL-6 are mediated via IL-6 “trans-signaling,” a…”
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Defective cholesterol metabolism in haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritis by Dragoljevic, Dragana, Kraakman, Michael J, Nagareddy, Prabhakara R, Ngo, Devi, Shihata, Waled, Kammoun, Helene L, Whillas, Alexandra, Lee, Man Kit Sam, Al-Sharea, Annas, Pernes, Gerard, Flynn, Michelle C, Lancaster, Graeme I, Febbraio, Mark A, Chin-Dusting, Jaye, Hanaoka, Beatriz Y, Wicks, Ian P, Murphy, Andrew J

“…Abstract Aim Rheumatoid arthritis (RA) is associated with an approximately two-fold elevated risk of cardiovascular (CV)-related mortality. Patients with RA…”
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Hepatitis C Virus Proteins Induce Lipogenesis and Defective Triglyceride Secretion in Transgenic Mice by Lerat, Hervé, Kammoun, Hélène L., Hainault, Isabelle, Mérour, Emilie, Higgs, Martin R., Callens, Céline, Lemon, Stanley M., Foufelle, Fabienne, Pawlotsky, Jean-Michel

“…Chronic hepatitis C virus (HCV) infection is associated with altered lipid metabolism and hepatocellular steatosis. Virus-induced steatosis is a cytopathic…”
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Come on BAIBA Light My Fire by Kammoun, Helene L., Febbraio, Mark A.

“…The contracting muscle has been shown to act as an endocrine organ, secreting “myokines” that participate in tissue crosstalk. In this issue of Cell…”
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Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis by Flamment, Mélissa, Kammoun, Hélène L, Hainault, Isabelle, Ferré, Pascal, Foufelle, Fabienne

“…To examine the role of endoplasmic reticulum stress in the regulation of hepatic lipid metabolism and its contribution to the development of hepatic steatosis…”
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Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice by Kammoun, Helene L, Allen, Tamara Louise, Henstridge, Darren Colin, Kraakman, Michael James, Peijs, Lone, Rose-John, Stefan, Febbraio, Mark Anthony

“…Non-alcoholic steatohepatitis (NASH) is a liver disease with the potential to lead to cirrhosis and hepatocellular carcinoma. Interleukin-6 (IL-6) has been…”
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Leptin-deficient obesity prolongs survival in a murine model of myelodysplastic syndrome by Kraakman, Michael J, Kammoun, Helene L, Dragoljevic, Dragana, Al-Sharea, Annas, Lee, Man K S, Flynn, Michelle C, Stolz, Christian J, Guirguis, Andrew A, Lancaster, Graeme I, Chin-Dusting, Jaye, Curtis, David J, Murphy, Andrew J

“…Obesity enhances the risk of developing myelodysplastic syndromes. However, the effect of obesity on survival is unclear. Obese people present with monocytosis…”
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Nutritional related liver disease: targeting the endoplasmic reticulum stress by Kammoun, Hélène L, Hainault, Isabelle, Ferré, Pascal, Foufelle, Fabienne

“…PURPOSE OF REVIEWNutritional hepatic disorders are spreading worldwide associated to obesity and type 2 diabetes. The underlying mechanisms leading to the…”
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Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms by Riddy, Darren M, Kammoun, Helene L, Murphy, Andrew J, Bosnyak-Gladovic, Sanja, De la Fuente Gonzalez, Rocio, Merlin, Jon, Ziemann, Mark, Fabb, Stewart, Pierce, Tracie L, Diepenhorst, Natalie, Rueda, Patricia, El-Osta, Assam, Gautier, Jean-Francois, Venteclef, Nicolas, Charman, William N, Christopoulos, Arthur, Sexton, Patrick M, Summers, Roger J, Febbraio, Mark A, Delerive, Philippe, Langmead, Christopher J

“…IntroductionA potential role for the orphan G protein-coupled receptor, GPR21, in linking immune cell infiltration into tissues and obesity-induced insulin…”
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The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice by Lancaster, Graeme I, Kraakman, Michael J, Kammoun, Helene L, Langley, Katherine G, Estevez, Emma, Banerjee, Ashish, Grumont, Raelene J, Febbraio, Mark A, Gerondakis, Steve

“…Alterations in the immune cell profile and the induction of inflammation within adipose tissue are a hallmark of obesity in mice and humans. Dual-specificity…”
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Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism by Lancaster, Graeme I., Langley, Katherine G., Berglund, Nils Anton, Kammoun, Helene L., Reibe, Saskia, Estevez, Emma, Weir, Jacquelyn, Mellett, Natalie A., Pernes, Gerard, Conway, James R.W., Lee, Man K.S., Timpson, Paul, Murphy, Andrew J., Masters, Seth L., Gerondakis, Steve, Bartonicek, Nenad, Kaczorowski, Dominik C., Dinger, Marcel E., Meikle, Peter J., Bond, Peter J., Febbraio, Mark A.

“…Chronic inflammation is a hallmark of obesity and is linked to the development of numerous diseases. The activation of toll-like receptor 4 (TLR4) by…”
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High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice by Heywood, Sarah E, Richart, Adele L, Henstridge, Darren C, Alt, Karen, Kiriazis, Helen, Zammit, Claire, Carey, Andrew L, Kammoun, Helene L, Delbridge, Lea M, Reddy, Medini, Chen, Yi-Ching, Du, Xiao-Jun, Hagemeyer, Christoph E, Febbraio, Mark A, Siebel, Andrew L, Kingwell, Bronwyn A

“…Protecting the heart after an acute coronary syndrome is a key therapeutic goal to support cardiac recovery and prevent progression to heart failure. A…”
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Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice by Jordy, Andreas B, Kraakman, Michael J, Gardner, Tim, Estevez, Emma, Kammoun, Helene L, Weir, Jacqui M, Kiens, Bente, Meikle, Peter J, Febbraio, Mark A, Henstridge, Darren C

“…The accumulation of lipid at ectopic sites, including the skeletal muscle and liver, is a common consequence of obesity and is associated with tissue-specific…”
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Skeletal muscle‐specific overexpression of heat shock protein 72 improves skeletal muscle insulin‐stimulated glucose uptake but does not alter whole body metabolism by Marshall, Jessica P. S., Estevez, Emma, Kammoun, Helene L., King, Emily J., Bruce, Clinton R., Drew, Brian G., Qian, Hongwei, Iliades, Peter, Gregorevic, Paul, Febbraio, Mark A., Henstridge, Darren C.

“…Aims The induction of heat shock protein 72 (Hsp72) via heating, genetic manipulation or pharmacological activation is metabolically protective in the setting…”
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Is the risk of cardiovascular disease altered with anti‐inflammatory therapies? Insights from rheumatoid arthritis by Kraakman, Michael J, Dragoljevic, Dragana, Kammoun, Helene L, Murphy, Andrew J

“…Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. Atherosclerosis is the most common form of CVD, which is complex and…”
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