Search Results - "Kammen, Rob A."

The Par-Tiam1 Complex Controls Persistent Migration by Stabilizing Microtubule-Dependent Front-Rear Polarity by Pegtel, D. Michiel, Ellenbroek, Saskia I.J., Mertens, Alexander E.E., van der Kammen, Rob A., de Rooij, Johan, Collard, John G.

“…The establishment and maintenance of cell polarity is crucial for many biological functions and is regulated by conserved protein complexes. The Par polarity…”
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RhoA activation promotes transendothelial migration of monocytes via ROCK by Honing, Henk, Berg, Timo K., Pol, Susanne M. A., Dijkstra, Christine D., Kammen, Rob A., Collard, John G., Vries, Helga E.

“…Monocyte infiltration into inflamed tissue requires the initial arrest of the cells on the endothelium followed by firm adhesion and their subsequent…”
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The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho by van Leeuwen, Frank N., Hendrie E. T. Kain, van der Kammen, Rob A., Michiels, Frits, Kranenburg, Onno W., Collard, John G.

“…The invasion-inducing T-lymphoma invasion and metastasis 1 (Tiam1) protein functions as a guanine nucleotide exchange factor (GEF) for the small GTPase Rac1…”
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Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours by Collard, John G, Malliri, Angeliki, van der Kammen, Rob A, Clark, Kristopher, van der Valk, Maarten, Michiels, Frits

“…Proteins of the Rho family control signalling pathways that regulate the actin cytoskeleton and gene transcription. In vitro studies have implicated Rho-like…”
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Par polarity complex regulates Rap1- and chemokine-induced T cell polarization by Gérard, Audrey, Mertens, Alexander E.E, van der Kammen, Rob A, Collard, John G

“…Cell polarization is required for virtually all functions of T cells, including transendothelial migration in response to chemokines. However, the molecular…”
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The Rac Activator Tiam1 Is a Wnt-responsive Gene That Modifies Intestinal Tumor Development by Malliri, Angeliki, Rygiel, Tomasz P., van der Kammen, Rob A., Song, Ji-Ying, Engers, Rainer, Hurlstone, Adam F.L., Clevers, Hans, Collard, John G.

“…Mutations in the canonical Wnt signaling pathway leading to its activation are known to cause the majority of intestinal tumors. However, few genes targeted by…”
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Inhibition of invasion of epithelial cells by Tiam1-Rac signaling by HORDIJK, P. L, TEN KLOOSTER, J. P, VAN DER KAMMEN, R. A, MICHIELS, F, OOMEN, L. C. J. M, COLLARD, J. G

“…Tiam1 encodes an exchange factor for the Rho-like guanosine triphosphatase Rac. Both Tiam1 and activated RacV12 promote invasiveness of T lymphoma cells. In…”
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A role for Rac in Tiaml-induced membrane ruffling and invasion by Michiels, Frits, Habets, Gaston G. M, Stam, Jord C, van der Kammen, Rob A, Collard, John G

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The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration by Gérard, Audrey, van der Kammen, Rob A., Janssen, Hans, Ellenbroek, Saskia I., Collard, John G.

“…Migration toward chemoattractants is a hallmark of T-cell trafficking and is essential to produce an efficient immune response. Here, we have analyzed the…”
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Regulated Membrane Localization of Tiam1, Mediated by the NH2-Terminal Pleckstrin Homology Domain, Is Required for Rac-Dependent Membrane Ruffling and C-Jun NH2-Terminal Kinase Activation by Michiels, Frits, Stam, Jord C., Hordijk, Peter L., van der Kammen, Rob A., Stalle, Lisette Ruuls-Van, Feltkamp, Constance A., Collard, John G.

“…Rho-like GTPases, including Cdc42, Rac, and Rho, regulate signaling pathways that control actin cytoskeletal structures and transcriptional activation. The…”
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Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling by Hajdo-Milasinovic, Amra, van der Kammen, Rob A, Moneva, Zvezdana, Collard, John G

“…Rac1 and Rac3 are highly homologous regulatory proteins that belong to the small GTPases of the Rho family. Previously, we showed that Rac3 induces cell…”
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Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading by Collard, John G, van Leeuwen, Frank N, van Delft, Sanne, Kain, Hendrie E, van der Kammen, Rob A

“…GTPases of the Rho family regulate actinomyosin-based contraction in non-muscle cells. Activation of Rho increases contractility, leading to cell rounding and…”
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Rac Downregulates Rho Activity: Reciprocal Balance between Both GTPases Determines Cellular Morphology and Migratory Behavior by Sander, Eva E., Jean P. ten Klooster, van Delft, Sanne, van der Kammen, Rob A., Collard, John G.

“…Using biochemical assays to determine the activation state of Rho-like GTPases, we show that the guanine nucleotide exchange factor Tiam1 functions as a…”
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Matrix-Dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell-Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase by Sander, Eva E., van Delft, Sanne, Jean P. ten Klooster, Reid, Tim, van der Kammen, Rob A., Michiels, Frits, Collard, John G.

“…We previously demonstrated that both Tiam1, an activator of Rac, and constitutively active V12Rac promote E-cadherin-mediated cell-cell adhesion in epithelial…”
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The Rac Activator Tiam1 Is Required for α3β1-mediated laminin-5 Deposition, Cell Spreading, and Cell Migration by Irene H. L. Hamelers, Olivo, Cristina, Alexander E. E. Mertens, Pegtel, D. Michiel, van der Kammen, Rob A., Sonnenberg, Arnoud, Collard, John G.

“…The Rho-like guanosine triphosphatase Rac1 regulates various signaling pathways, including integrin-mediated adhesion and migration of cells. However, the…”
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Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial-Mesenchymal Transition by Gerben C. M. Zondag, Evers, Eva E., Jean P. ten Klooster, Janssen, Lennert, van der Kammen, Rob A., Collard, John G.

“…Proteins of the Rho family regulate cytoskeletal rearrangements in response to receptor stimulation and are involved in the establishment and maintenance of…”
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Rac activator Tiam1 is required for [alpha]3{szligbeta}1-mediated laminin-5 deposition, cell spreading, and cell migration by Hamelers, Irene H.L, Olivo, Cristina, Mertens, Alexander E.E, Pegtel, D. Michiel, Kammen, Rob A. van der, Sonnenberg, Arnoud, Collard, John G

“…The Rho-like guanosine triphosphatase Rac1 regulates various signaling pathways, including integrin-mediated adhesion and migration of cells. However, the…”
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Targeting of Tiam1 to the Plasma Membrane Requires the Cooperative Function of the N-terminal Pleckstrin Homology Domain and an Adjacent Protein Interaction Domain by Stam, Jord C., Sander, Eva E., Michiels, Frits, van Leeuwen, Frank N., Kain, Hendrie E.T., van der Kammen, Rob A., Collard, John G.

“…The Rho-like GTPases Cdc42, Rac, and Rho play key roles in the regulation of the actin cytoskeleton and are implicated in transcriptional activation and cell…”
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Inhibition of Invasion of Epithelial Cells by Tiam 1-Rac Signaling by Hordijk, Peter L., Jean Paul ten Klooster, van der Kammen, Rob A., Michiels, Frits, Lauran C. J. M. Oomen, Collard, John G.

“…Tiam1 encodes an exchange factor for the Rho-like guanosine triphosphatase Rac. Both Tiam1 and activated RacV12 promote invasiveness of T lymphoma cells. In…”
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The Rac activator Tiam1 is required for alpha 3 beta 1-mediated laminin-5 deposition, cell spreading, and cell migration by Hamelers, Irene HL, Olivo, Cristina, Mertens, Alexander EE, Pegtel, DMichiel, van der Kammen, Rob A, Sonnenberg, Arnoud, Collard, John G

“…The Rho-like guanosine triphosphatase Rac1 regulates various signaling pathways, including integrin-mediated adhesion and migration of cells. However, the…”
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