Search Results - "Kamme, Fredrik"

Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81 by Liu, Changlu, Wu, Jiejun, Zhu, Jessica, Kuei, Chester, Yu, Jingxue, Shelton, Jonathan, Sutton, Steven W., Li, Xiaorong, Yun, Su Jin, Mirzadegan, Taraneh, Mazur, Curt, Kamme, Fredrik, Lovenberg, Timothy W.

“…Lactic acid is a well known metabolic by-product of intense exercise, particularly under anaerobic conditions. Lactate is also a key source of energy and an…”
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A modular analysis of microglia gene expression, insights into the aged phenotype by Cho, Christine E, Damle, Sagar S, Wancewicz, Edward V, Mukhopadhyay, Swagatam, Hart, Christopher E, Mazur, Curt, Swayze, Eric E, Kamme, Fredrik

“…Microglia are multifunctional cells that are key players in brain development and homeostasis. Recent years have seen tremendous growth in our understanding of…”
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Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice by Yukawa, Kayo, Yamamoto-Mcguire, Satomi, Cafaro, Louis, Hong, Christine, Kamme, Fredrik, Ikezu, Tsuneya, Ikezu, Seiko

“…Tau tubulin kinase-1 (TTBK1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau pathology…”
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Single-Cell Microarray Analysis in Hippocampus CA1: Demonstration and Validation of Cellular Heterogeneity by Kamme, Fredrik, Salunga, Ranelle, Yu, Jingxue, Tran, Da-Thao, Zhu, Jessica, Luo, Lin, Bittner, Anton, Guo, Hong-Qing, Miller, Nancy, Wan, Jackson, Erlander, Mark

“…Laser capture microdissection in combination with microarrays allows for the expression analysis of thousands of genes in selected cells. Here we describe…”
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INSL5 Is a High Affinity Specific Agonist for GPCR142 (GPR100) by Liu, Changlu, Kuei, Chester, Sutton, Steven, Chen, Jingcai, Bonaventure, Pascal, Wu, Jiejun, Nepomuceno, Diane, Kamme, Fredrik, Tran, Da-Thao, Zhu, Jessica, Wilkinson, Tracey, Bathgate, Ross, Eriste, Elo, Sillard, Rannar, Lovenberg, Timothy W.

“…Insulin-like peptide 5 (INSL5) is a peptide that belongs to the relaxin/insulin family, and its receptor has not been identified. In this report, we…”
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Dopamine Depletion Induces Distinct Compensatory Gene Expression Changes in DARPP-32 Signal Transduction Cascades of Striatonigral and Striatopallidal Neurons by Meurers, Bernhard H, Dziewczapolski, Gustavo, Shi, Tao, Bittner, Anton, Kamme, Fredrik, Shults, Clifford W

“…Functional alterations in striatal projection neurons play a critical role in the development of motor symptoms in Parkinson's disease (PD), but their…”
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Dopamine depletion induced up-regulation of HCN3 enhances rebound excitability of basal ganglia output neurons by Meurers, Bernhard H, Dziewczapolski, Gustavo, Bittner, Anton, Shi, Tao, Kamme, Fredrik, Shults, Clifford W

“…Abstract Motor symptoms in Parkinson's disease (PD) are associated with complex changes of firing properties in basal ganglia output neurons (BGON). The…”
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Biphasic expression of the fos and jun families of transcription factors following transient forebrain ischaemia in the rat. Effect of hypothermia by Kamme, F, Campbell, K, Wieloch, T

“…Transient global ischaemia induces the expression of immediate early genes. Using in situ hybridization, the expression of c-fos, fosB, fra-1, fra-2, c-jun and…”
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R3(BΔ23–27)R/I5 Chimeric Peptide, a Selective Antagonist for GPCR135 and GPCR142 over Relaxin Receptor LGR7 by Kuei, Chester, Sutton, Steven, Bonaventure, Pascal, Pudiak, Cindy, Shelton, Jonathan, Zhu, Jessica, Nepomuceno, Diane, Wu, Jiejun, Chen, Jingcai, Kamme, Fredrik, Seierstad, Mark, Hack, Michael D., Bathgate, Ross A.D., Hossain, Mohammed Akhter, Wade, John D., Atack, John, Lovenberg, Timothy W., Liu, Changlu

“…Both relaxin-3 and its receptor (GPCR135) are expressed predominantly in brain regions known to play important roles in processing sensory signals. Recent…”
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Interferon-a receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy by Viengkhou, Barney, Hong, Christine, Mazur, Curt, Damle, Sagar, Gallo, Nicholas B, Fang, Terry C, Henry, Kate, Campbell, Iain L, Kamme, Fredrik, Hofer, Markus J

“…Chronic and elevated levels of the antiviral cytokine IFN-[alpha] in the brain are neurotoxic. This is best observed in patients with genetic cerebral…”
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Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy by Viengkhou, Barney, Hong, Christine, Mazur, Curt, Damie, Sagar, Gallo, Nicholas B, Fang, Terry C, Henry, Kate, Campbell, Iain L, Kamme, Fredrik, Hofer, Markus J

“…Chronic and elevated levels of the antiviral cytokine IFN-α in the brain are neurotoxic. This is best observed in patients with genetic cerebral…”
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A Novel Form of Neurotensin Post-translationally Modified by Arginylation by Eriste, Elo, Norberg, Åke, Nepomuceno, Diane, Kuei, Chester, Kamme, Fredrik, Tran, Da-Thao, Strupat, Kerstin, Jörnvall, Hans, Liu, Changlu, Lovenberg, Timothy W., Sillard, Rannar

“…A novel bioactive form of neurotensin post-translationally modified at a Glu residue was isolated from porcine intestine. Purification of the peptide was…”
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Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy by Viengkhou, Barney, Hong, Christine, Mazur, Curt, Damle, Sagar, Gallo, Nicholas B, Fang, Terry C, Henry, Kate, Campbell, Iain L, Kamme, Fredrik, Hofer, Markus J

“…Chronic and elevated levels of the antiviral cytokine IFN-α in the brain are neurotoxic. This is best observed in patients with genetic cerebral…”
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Development of a simple, rapid, and robust intrathecal catheterization method in the rat by Mazur, Curt, Fitzsimmons, Bethany, Kamme, Fredrik, Nichols, Brandon, Powers, Berit, Wancewicz, Ed

“…•A simple, rapid and robust method for the intrathecal catheterization of rats was developed.•The method uses a lumbar spinal approach minimizing insertion of…”
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Abstract 1162: RNA expression analysis of rare tumor cells by laser-mediated lysis by Kamme, Fredrik, Bright, Gary

“…Abstract Molecular analysis of live rare cells, such as circulating tumor cells (CTCs) is challenging. Current strategies include antibody-mediated capture and…”
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An Asymmetric Polymer Nanopore for Single Molecule Detection by Mara, Abraham, Siwy, Zuzanna, Trautmann, Christina, Wan, Jackson, Kamme, Fredrik

“…We describe a sensor capable of detecting single DNA molecules. The sensor is based on a single nanopore prepared in a polymer film by a latent ion…”
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Kinetics of ASO Distribution and Pharmacodynamics in the CNS after an Intrathecal Bolus Dose in Rat (S38.008) by Swayze, Eric, Powers, Berit, Kamme, Fredrik, Mazur, Curt, Wolf, Daniel, Sullivan, Jenna, Verma, Ajay

“…Abstract only…”
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Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging by Mazur, Curt, Powers, Berit, Zasadny, Kenneth, Sullivan, Jenna M., Dimant, Hemi, Kamme, Fredrik, Hesterman, Jacob, Matson, John, Oestergaard, Michael, Seaman, Marc, Holt, Robert W., Qutaish, Mohammed, Polyak, Ildiko, Coelho, Richard, Gottumukkala, Vijay, Gaut, Carolynn M., Berridge, Marc, Albargothy, Nazira J., Kelly, Louise, Carare, Roxana O., Hoppin, Jack, Kordasiewicz, Holly, Swayze, Eric E., Verma, Ajay

“…Intrathecal (IT) delivery and pharmacology of antisense oligonucleotides (ASOs) for the CNS have been successfully developed to treat spinal muscular atrophy…”
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R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization by Kuei, Chester, Sutton, Steven, Bonaventure, Pascal, Pudiak, Cindy, Shelton, Jonathan, Zhu, Jessica, Nepomuceno, Diane, Wu, Jiejun, Chen, Jingcai, Kamme, Fredrik, Seierstad, Mark, Hack, Michael D, Bathgate, Ross A D, Hossain, Mohammed Akhter, Wade, John D, Atack, John, Lovenberg, Timothy W, Liu, Changlu

“…Both relaxin-3 and its receptor (GPCR135) are expressed predominantly in brain regions known to play important roles in processing sensory signals. Recent…”
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Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1 by Chen, Jingcai, Kuei, Chester, Sutton, Steven, Wilson, Sandy, Yu, Jingxue, Kamme, Fredrik, Mazur, Curt, Lovenberg, Timothy, Liu, Changlu

“…Prokineticins 1 and 2 (PK1 and PK2) have been recently identified from humans and other mammals and play multiple functional roles. PK proteins are ligands for…”
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