Search Results - "Kamm, D"

Engineered 3D vascular and neuronal networks in a microfluidic platform by Osaki, Tatsuya, Sivathanu, Vivek, Kamm, Roger D.

“…Neurovascular coupling plays a key role in the pathogenesis of neurodegenerative disorders including motor neuron disease (MND). In vitro models provide an…”
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Impact of the physical microenvironment on tumor progression and metastasis by Spill, Fabian, Reynolds, Daniel S, Kamm, Roger D, Zaman, Muhammad H

“…Graphical abstract…”
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Biology and Models of the Blood-Brain Barrier by Hajal, Cynthia, Le Roi, Baptiste, Kamm, Roger D, Maoz, Ben M

“…The blood-brain barrier (BBB) is one of the most selective endothelial barriers. An understanding of its cellular, morphological, and biological properties in…”
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Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices by Malandrino, Andrea, Trepat, Xavier, Kamm, Roger D, Mak, Michael

“…The mechanical properties of the extracellular matrix (ECM)-a complex, 3D, fibrillar scaffold of cells in physiological environments-modulate cell behavior and…”
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Interstitial flow influences direction of tumor cell migration through competing mechanisms by Polacheck, William J, Charest, Joseph L, Kamm, Roger D

“…Interstitial flow is the convective transport of fluid through tissue extracellular matrix. This creeping fluid flow has been shown to affect the morphology…”
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Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons by Osaki, Tatsuya, Uzel, Sebastien G M, Kamm, Roger D

“…Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease involving loss of motor neurons (MNs) and muscle atrophy, still has no effective…”
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Rethinking organoid technology through bioengineering by Garreta, Elena, Kamm, Roger D., Chuva de Sousa Lopes, Susana M., Lancaster, Madeline A., Weiss, Ron, Trepat, Xavier, Hyun, Insoo, Montserrat, Nuria

“…In recent years considerable progress has been made in the development of faithful procedures for the differentiation of human pluripotent stem cells (hPSCs)…”
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Cell contraction induces long-ranged stress stiffening in the extracellular matrix by Han, Yu Long, Ronceray, Pierre, Xu, Guoqiang, Malandrino, Andrea, Kamm, Roger D., Lenz, Martin, Broedersz, Chase P., Guo, Ming

“…Animal cells in tissues are supported by biopolymer matrices, which typically exhibit highly nonlinear mechanical properties. While the linear elasticity of…”
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Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation by Jeon, Jessie S., Bersini, Simone, Gilardi, Mara, Dubini, Gabriele, Charest, Joseph L., Moretti, Matteo, Kamma, Roger D.

“…Significance The cancer biology seed-and-soil paradigm recognizes the existence of organ-specific patterns of metastasization that drive the spread of selected…”
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On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics by Chen, Michelle B, Whisler, Jordan A, Fröse, Julia, Yu, Cathy, Shin, Yoojin, Kamm, Roger D

“…This protocol describes how to set up and use an in vitro model of the human microcirculation with the capability to recapitulate discrete steps of early…”
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Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy by Scarcelli, Giuliano, Polacheck, William J, Nia, Hadi T, Patel, Kripa, Grodzinsky, Alan J, Kamm, Roger D, Yun, Seok Hyun

“…Brillouin microscopy can be used to analyze the mechanical properties of cells in a contact-free fashion. Cells in 2D and 3D environments are accessible to…”
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Optogenetic skeletal muscle-powered adaptive biological machines by Raman, Ritu, Cvetkovic, Caroline, Uzel, Sebastien G. M., Platt, Randall J., Sengupta, Parijat, Kamm, Roger D., Bashir, Rashid

“…Complex biological systems sense, process, and respond to their surroundings in real time. The ability of such systems to adapt their behavioral response to…”
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Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function by Zervantonakis, Ioannis K, Hughes-Alford, Shannon K, Charest, Joseph L, Condeelis, John S, Gertler, Frank B, Kamm, Roger D

“…Entry of tumor cells into the blood stream is a critical step in cancer metastasis. Although significant progress has been made in visualizing tumor cell…”
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Mechanotransduction of fluid stresses governs 3D cell migration by Polacheck, William J., German, Alexandra E., Mammoto, Akiko, Ingber, Donald E., Kamm, Roger D.

“…Solid tumors are characterized by high interstitial fluid pressure, which drives fluid efflux from the tumor core. Tumor-associated interstitial flow (IF) at a…”
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Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade by Chen, Michelle B, Lamar, John M, Li, Ran, Hynes, Richard O, Kamm, Roger D

“…Tumor integrin β1 (ITGB1) contributes to primary tumor growth and metastasis, but its specific roles in extravasation have not yet been clearly elucidated. In…”
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Computational modeling of three-dimensional ECM-rigidity sensing to guide directed cell migration by Kim, Min-Cheol, Silberberg, Yaron R., Abeyaratne, Rohan, Kamm, Roger D., Asada, H. Harry

“…Filopodia have a key role in sensing both chemical and mechanical cues in surrounding extracellular matrix (ECM). However, quantitative understanding is still…”
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Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation by Chen, Michelle B., Hajal, Cynthia, Benjamin, David C., Yu, Cathy, Azizgolshani, Hesham, Hynes, Richard O., Kamm, Roger D.

“…Systemic inflammation occurring around the course of tumor progression and treatment are often correlatedwith adverse oncological outcomes. As such, it is…”
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A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines by Song, Jiho, Miermont, Agnès, Lim, Chwee Teck, Kamm, Roger D.

“…Hypoxia is a common feature of the tumor microenvironment. Accumulating evidence has demonstrated hypoxia to be an important trigger of tumor cell invasion or…”
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A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs by Kim, Choong, Kasuya, Junichi, Jeon, Jessie, Chung, Seok, Kamm, Roger D

“…Anti-angiogenic therapy, which suppresses tumor growth by disrupting oxygen and nutrient supply from blood to the tumor, is now widely accepted as a treatment…”
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The bioprinting roadmap by Sun, Wei, Starly, Binil, Daly, Andrew C, Burdick, Jason A, Groll, Jürgen, Skeldon, Gregor, Shu, Wenmiao, Sakai, Yasuyuki, Shinohara, Marie, Nishikawa, Masaki, Jang, Jinah, Cho, Dong-Woo, Nie, Minghao, Takeuchi, Shoji, Ostrovidov, Serge, Khademhosseini, Ali, Kamm, Roger D, Mironov, Vladimir, Moroni, Lorenzo, Ozbolat, Ibrahim T

“…This bioprinting roadmap features salient advances in selected applications of the technique and highlights the status of current developments and challenges,…”
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