Limosilactobacillus reuteri DSM 17938 supplementation and SARS-CoV-2 specific antibody response in healthy adults: a randomized, triple-blinded, placebo-controlled trial

Limosilactobacillus reuteri DSM 17938 supplementation and SARS-CoV-2 specific antibody response in healthy adults: a randomized, triple-blinded, placebo-controlled trial

Studies have shown that probiotics can decrease the symptoms of respiratory tract infections as well as increase antibody responses following certain vaccinations. We examined the effect of probiotic supplementation on anti-SARS-CoV-2 specific antibody responses upon SARS-CoV-2 infection as well as...

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Bibliographic Details
Published in:Gut microbes Vol. 15; no. 1; p. 2229938
Main Authors: Forsgård, Richard A., Rode, Julia, Lobenius-Palmér, Karin, Kamm, Annalena, Patil, Snehal, Tacken, Mirriam G. J., Lentjes, Marleen A. H., Axelsson, Jakob, Grompone, Gianfranco, Montgomery, Scott, Brummer, Robert J.
Format: Journal Article
Language:English
Published: United States Taylor & Francis 2023
Taylor & Francis Group
Subjects:
Adult
Antibodies, Viral
antibody
Antibody Formation
Cholecalciferol
COVID-19
COVID-19 Vaccines
Gastrointestinal Microbiome
Humans
Immunoglobulin A
Immunoglobulin G
immunology
Limosilactobacillus reuteri
Medicin och hälsovetenskap
Probiotics
Research Paper
RNA, Messenger
SARS-CoV-2
COVID-19
Probiotics
SARS-CoV-2
antibody
immunology
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Summary:Studies have shown that probiotics can decrease the symptoms of respiratory tract infections as well as increase antibody responses following certain vaccinations. We examined the effect of probiotic supplementation on anti-SARS-CoV-2 specific antibody responses upon SARS-CoV-2 infection as well as after COVID-19 vaccination. In this randomized, triple-blinded, placebo-controlled intervention study with a parallel design, 159 healthy adults without prior SARS-CoV-2 infection or COVID-19 vaccination and any known risk factors for severe COVID-19 were randomly allocated into two study arms. The active treatment arm consumed a probiotic product containing a minimum of 1 × 10 8 colony-forming units of Limosilactobacillus reuteri DSM 17938 + 10 μg vitamin D3 twice daily for 6 months. The placebo arm consumed identical tablets containing only 10 μg vitamin D3. Anti-SARS-CoV-2 specific antibodies and virus neutralizing antibody titers were analyzed from blood samples collected at baseline, after 3 months, and after 6 months. Differences in serum antibody titers between the two study arms were tested with independent t-test using log-transformed values. In the intention-to-treat (ITT) analysis, SARS-CoV-2 infected individuals in the active treatment arm (n = 6) tended to have higher serum anti-spike IgG (609 [168-1480] BAU/ml vs 111 [36.1-1210] BAU/ml, p = 0.080) and anti-receptor binding domain (RBD) IgG (928 [212-3449] BAU/ml vs (83.7 [22.8-2094] BAU/ml, p = 0.066) levels than individuals in the placebo arm (n = 6). Considering individuals who were fully vaccinated with mRNA-based COVID-19 vaccines, the active treatment arm (n = 10) exhibited significantly higher serum levels of anti-RBD IgA (135 [32.9-976] BAU/ml vs 61.3 [26.7-97.1] BAU/ml, p = 0.036) than the placebo arm (n = 7) >28 days postvaccination. Supplementation with specific probiotics might improve the long-term efficacy of mRNA-based COVID-19 vaccines via enhanced IgA response.
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ISSN:1949-0976
1949-0984
1949-0984
DOI:10.1080/19490976.2023.2229938