Search Results - "Kamiya, Akihide"

A Deactivation Factor of Fibrogenic Hepatic Stellate Cells Induces Regression of Liver Fibrosis in Mice by Nakano, Yasuhiro, Kamiya, Akihide, Sumiyoshi, Hideaki, Tsuruya, Kota, Kagawa, Tatehiro, Inagaki, Yutaka

“…Background and Aims Hepatic stellate cells (HSCs), a key player in the progression of liver fibrosis, are activated by various inflammatory stimuli and…”
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Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts by Anzai, Kazuya, Tsuruya, Kota, Ida, Kinuyo, Kagawa, Tatehiro, Inagaki, Yutaka, Kamiya, Akihide

“…The liver is an important metabolic organ that controls homeostasis in the body. Moreover, it functions as a hematopoietic organ, while its metabolic function…”
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Liver-specific knockout of B cell lymphoma 6 suppresses progression of non-alcoholic steatohepatitis in mice by Chikada, Hiromi, Ida, Kinuyo, Nishikawa, Yuji, Inagaki, Yutaka, Kamiya, Akihide

“…The prevalence of non-alcoholic steatohepatitis (NASH) rapidly increases with metabolic disorders such as dyslipidaemia, high blood pressure, and…”
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An in vitro expansion system for generation of human iPS cell-derived hepatic progenitor-like cells exhibiting a bipotent differentiation potential by Yanagida, Ayaka, Ito, Keiichi, Chikada, Hiromi, Nakauchi, Hiromitsu, Kamiya, Akihide

“…Hepatoblasts, hepatic stem/progenitor cells in liver development, have a high proliferative potential and the ability to differentiate into both hepatocytes…”
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Liver Injury and Cell Survival in Non-Alcoholic Steatohepatitis Regulated by Sex-Based Difference through B Cell Lymphoma 6 by Kamiya, Akihide, Ida, Kinuyo

“…The liver is a crucial organ for maintaining homeostasis in living organisms and is the center of various metabolic functions. Therefore, abnormal metabolic…”
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Branched-chain amino acids govern the high learning ability phenotype in Tokai high avoider (THA) rats by Shida, Yukari, Endo, Hitoshi, Owada, Satoshi, Inagaki, Yutaka, Sumiyoshi, Hideaki, Kamiya, Akihide, Eto, Tomoo, Tatemichi, Masayuki

“…To fully understand the mechanisms governing learning and memory, animal models with minor interindividual variability and higher cognitive function are…”
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Enrichment and Clonal Culture of Progenitor Cells During Mouse Postnatal Liver Development in Mice by Kamiya, Akihide, Kakinuma, Sei, Yamazaki, Yuji, Nakauchi, Hiromitsu

“…Background & Aims Stem and progenitor cells exist in normal postnatal livers. However, it has not been possible to clonally isolate or analyze postnatal liver…”
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Abcb4-defect cholangitis mouse model with hydrophobic bile acid composition by in vivo liver-specific gene deletion by Tsuruya, Kota, Yokoyama, Keiko, Mishima, Yusuke, Ida, Kinuyo, Araki, Takuma, Ieda, Satsuki, Ohtsuka, Masato, Inagaki, Yutaka, Honda, Akira, Kagawa, Tatehiro, Kamiya, Akihide

“…Progressive familial intrahepatic cholestasis (PFIC) is a liver disease that occurs during childhood and requires liver transplantation. ABCB4 is localized…”
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Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells by Tsuneishi, Ruri, Saku, Noriaki, Miyata, Shoko, Akiyama, Saeko, Javaregowda, Palaksha Kanive, Ite, Kenta, Takashima, Nagisa, Toyoda, Masashi, Kimura, Tohru, Kuroda, Masahiko, Nakazawa, Atsuko, Kasahara, Mureo, Nonaka, Hidenori, Kamiya, Akihide, Kiyono, Tohru, Yamauchi, Junji, Umezawa, Akihiro

“…Ammonia has a cytotoxic effect and can therefore be used as a selection agent for enrichment of zone I hepatocytes. However, it has not yet been determined…”
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Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver by AlOgayil, Najla, Bauermeister, Klara, Galvez, Jose Hector, Venkatesh, Varun S., Zhuang, Qinwei Kim-wee, Chang, Matthew L., Davey, Rachel A., Zajac, Jeffrey D., Ida, Kinuyo, Kamiya, Akihide, Taketo, Teruko, Bourque, Guillaume, Naumova, Anna K.

“…Sexual dimorphism in gene regulation, including DNA methylation, is the main driver of sexual dimorphism in phenotypes. However, the questions of how and when…”
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Cancer stem cells in hepatocellular carcinoma: Recent progress and perspective by Chiba, Tetsuhiro, Kamiya, Akihide, Yokosuka, Osamu, Iwama, Atsushi

“…Abstract Although the “cancer stem cell (CSC)” hypothesis was first proposed roughly 50 years ago, recent progress in stem cell biology and technologies has…”
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LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells by Miyoshi, Masato, Kakinuma, Sei, Kamiya, Akihide, Tsunoda, Tomoyuki, Tsuchiya, Jun, Sato, Ayako, Kaneko, Shun, Nitta, Sayuri, Kawai-Kitahata, Fukiko, Murakawa, Miyako, Itsui, Yasuhiro, Nakagawa, Mina, Azuma, Seishin, Nakauchi, Hiromitsu, Asahina, Yasuhiro, Watanabe, Mamoru

“…Human induced pluripotent stem (iPS) cells can differentiate into hepatocyte lineages, although the phenotype of the differentiated cells is immature compared…”
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Author Correction: Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver by AlOgayil, Najla, Bauermeister, Klara, Galvez, Jose Hector, Venkatesh, Varun S., Zhuang, Qinwei Kim-wee, Chang, Matthew L., Davey, Rachel A., Zajac, Jeffrey D., Ida, Kinuyo, Kamiya, Akihide, Taketo, Teruko, Bourque, Guillaume, Naumova, Anna K.

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Stem and progenitor cell systems in liver development and regeneration by Kamiya, Akihide, Inagaki, Yutaka

“…The liver comprises two stem/progenitor cell systems: fetal and adult liver stem/progenitor cells. Fetal hepatic progenitor cells, derived from foregut…”
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Loss of fibrocystin promotes interleukin-8-dependent proliferation and CTGF production of biliary epithelium by Tsunoda, Tomoyuki, Kakinuma, Sei, Miyoshi, Masato, Kamiya, Akihide, Kaneko, Shun, Sato, Ayako, Tsuchiya, Jun, Nitta, Sayuri, Kawai-Kitahata, Fukiko, Murakawa, Miyako, Itsui, Yasuhiro, Nakagawa, Mina, Azuma, Seishin, Sogo, Tsuyoshi, Komatsu, Haruki, Mukouchi, Ryutaro, Inui, Ayano, Fujisawa, Tomoo, Nakauchi, Hiromitsu, Asahina, Yasuhiro, Watanabe, Mamoru

“…[Display omitted] •We established a human iPS cell-model of congenital hepatic fibrosis.•Loss of fibrocystin increases the production of IL-8 in…”
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The basic helix-loop-helix transcription factor, Mist1, induces maturation of mouse fetal hepatoblasts by Chikada, Hiromi, Ito, Keiichi, Yanagida, Ayaka, Nakauchi, Hiromitsu, Kamiya, Akihide

“…Hepatic stem/progenitor cells, hepatoblasts, have a high proliferative ability and can differentiate into mature hepatocytes and cholangiocytes. Therefore,…”
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Drug metabolic activity is a critical cell-intrinsic determinant for selection of hepatocytes during long-term culture by Akiyama, Saeko, Saku, Noriaki, Miyata, Shoko, Ite, Kenta, Toyoda, Masashi, Kimura, Tohru, Kuroda, Masahiko, Nakazawa, Atsuko, Kasahara, Mureo, Nonaka, Hidenori, Kamiya, Akihide, Kiyono, Tohru, Kobayshi, Tohru, Murakami, Yasufumi, Umezawa, Akihiro

“…The liver plays an important role in various metabolic processes, including protein synthesis, lipid and drug metabolisms and detoxifications. Primary culture…”
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Identification of a Novel Bone Marrow Cell‐Derived Accelerator of Fibrotic Liver Regeneration Through Mobilization of Hepatic Progenitor Cells in Mice by Yanagawa, Takayo, Sumiyoshi, Hideaki, Higashi, Kiyoshi, Nakao, Sachie, Higashiyama, Reiichi, Fukumitsu, Hiroshi, Minakawa, Kaori, Chiba, Yosuke, Suzuki, Yuhei, Sumida, Kayo, Saito, Koichi, Kamiya, Akihide, Inagaki, Yutaka

“…Granulocyte colony stimulating factor (G‐CSF) has been reported to ameliorate impaired liver function in patients with advanced liver diseases through…”
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An in vitro model of polycystic liver disease using genome-edited human inducible pluripotent stem cells by Kamiya, Akihide, Chikada, Hiromi, Ida, Kinuyo, Ando, Emi, Tsuruya, Kota, Kagawa, Tatehiro, Inagaki, Yutaka

“…In the developing liver, bile duct structure is formed through differentiation of hepatic progenitor cells (HPC) into cholangiocytes. A subtype of polycystic…”
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Enrichment and clonal culture of hepatic stem/progenitor cells during mouse liver development by Kamiya, Akihide, Nakauchi, Hiromitsu

“…Liver regenerates after hepatectomy or chemical-induced injury. In contrast to cells in other tissues that can regenerate, mature cells (hepatocytes), but not…”
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