Search Results - "Kamishohara, Masaru"

KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth by Nakamura, Kazuhide, Yamamoto, Atsushi, Kamishohara, Masaru, Takahashi, Kazumi, Taguchi, Eri, Miura, Toru, Kubo, Kazuo, Shibuya, Masabumi, Isoe, Toshiyuki

“…Vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 play a central role in angiogenesis, which is necessary for solid tumors to expand and…”
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Is Lymphoid Leukemia Less Susceptible to Busulfan Than Myeloid Leukemia? Comparison of Cytotoxicities of Busulfan, Melphalan, Fludarabine, Clofarabine, Cytosine Arabinoside, and Etoposide in Human Myeloid and Lymphoid Leukemia Cell Lines by Kamishohara, Masaru, DVM, PhD, Komatsubara, Hirofumi, PhD, Kakinuma, Hayato, Tanaka, Ryo, Nakamura, Yuki, Kobayashi, Hiroyuki, MD, PhD

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Selective Accumulation of the Endoplasmic Reticulum–Golgi Intermediate Compartment Induced by the Antitumor Drug KRN5500 by Kamishohara, Masaru, Kenney, Susan, Domergue, Renee, Vistica, David T., Sausville, Edward A.

“…KRN5500 is a semisynthetic spicamycin analogue consisting of a seven-carbon amino sugar linked to a C14 unsaturated fatty acid through glycine and to the amino…”
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Vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic by Shindo, K, Kamishohara, M, Odagawa, A, Matsuoka, M, Kawai, H

“…A new antitumor antibiotic vicenistatin was isolated from the culture broth of Streptomyces sp. HC34. The structure of vicenistatin was elucidated by NMR…”
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Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice by Nakagawa, R, Nagafune, I, Tazunoki, Y, Ehara, H, Tomura, H, Iijima, R, Motoki, K, Kamishohara, M, Seki, S

“…The role of mouse liver NK1.1 Ag(+) T (NKT) cells in the antitumor effect of alpha-galactosylceramide (alpha-GalCer) has been unclear. We now show that,…”
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The Molecular Interaction of Fas and FAP-1 by Yanagisawa, Junn, Takahashi, Motoo, Kanki, Hiroaki, Yano-Yanagisawa, Hiroko, Tazunoki, Tetsushi, Sawa, Eiji, Nishitoba, Tsuyoshi, Kamishohara, Masaru, Kobayashi, Eiichi, Kataoka, Shiro, Sato, Takaaki

“…Fas (APO-1/CD95), which is a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that induces apoptosis. A protein tyrosine…”
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Structure-antitumor activity relationship of semi-synthetic spicamycin analogues by Kamishohara, M, Kawai, H, Odagawa, A, Isoe, T, Mochizuki, J, Uchida, T, Hayakawa, Y, Seto, H, Tsuruo, T, Otake, N

“…Spicamycin, a nucleoside antibiotic containing fatty acids with a variety of chain lengths (C12-C18), showed potent antitumor activity against human gastric…”
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Pharmacological characteristics and clinical outcomes of ponatinib (Iclusig ® ), a third-generation tyrosine kinase inhibitor by Yoshida, Takahiro, Leen Liew, Ei, Ota, Mihoko, Nakayama, Hiroshi, Yanagihara, Yasuo, Nakamura, Yuki, Seriu, Taku, Kamishohara, Masaru

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Structure-antitumor activity relationship of semi-synthetic Spicamycin derivatives by Sakai, T, Kawai, H, Kamishohara, M, Odagawa, A, Suzuki, A, Uchida, T, Kawasaki, T, Tsuruo, T, Otake, N

“…New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined…”
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Antitumor activity of SPM VIII, a derivative of the nucleoside antibiotic spicamycin, against human tumor xenografts by Kamishohara, M, Kawai, H, Odagawa, A, Isoe, T, Mochizuki, J, Uchida, T, Hayakawa, Y, Seto, H, Tsuruo, T, Otake, N

“…The antitumor activity of spicamycin analogue SPM VIII against human stomach, breast, lung, colon and esophageal cancers was compared to that of mitomycin C…”
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Synthesis and antitumor activities of glycine-exchanged analogs of spicamycin by Sakai, T, Kawai, H, Kamishohara, M, Odagawa, A, Suzuki, A, Uchida, T, Kawasaki, T, Tsuruo, T, Otake, N

“…A series of SPM VIII analogs were synthesized to investigate the effect of the amino acid moiety on the antitumor activity. The L-threonine analog and the…”
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The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis by Yanagisawa, J, Takahashi, M, Kanki, H, Yano-Yanagisawa, H, Tazunoki, T, Sawa, E, Nishitoba, T, Kamishohara, M, Kobayashi, E, Kataoka, S, Sato, T

“…Fas (APO-1/CD95), which is a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that induces apoptosis. A protein tyrosine…”
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Intravenous Busulfan-Based Myeloablative Conditioning Regimens Prior to Hematopoietic Cell Transplantation for Hematologic Malignancies by Pasquini, Marcelo C, Le-Rademacher, Jennifer, Zhu, Xiaochun, Artz, Andrew, DiPersio, John, Fernandez, Hugo F, Mineishi, Shin, Kamishohara, Masaru, Mehta, Jayesh, Nakamura, Yuki, Ratanatharathorn, Voravit, Sobecks, Ronald, Burkart, Jeanne, Bredeson, Christopher

“…Abstract Busulfan (Bu)-containing regimens are commonly used in myeloablative conditioning regimens before allogeneic hematopoietic cell transplantation (HCT)…”
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Structural Modification of Fas C-Terminal Tripeptide and Its Effects on the Inhibitory Activity of Fas/FAP-1 Binding by Sawa, Eiji, Takahashi, Motoo, Kamishohara, Masaru, Tazunoki, Tetsushi, Kimura, Kaname, Arai, Midori, Miyazaki, Tetsuko, Kataoka, Shiro, Nishitoba, Tsuyoshi

“…We report the structural requirements of the C-terminal tripeptide derivative of Fas (Ac-Ser-Leu-Val-OH, 1) for the inhibitory activity of Fas/FAP-1 binding…”
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Inhibitory effect of a spicamycin derivative, KRN5500, on the growth of hepatic metastasis of human colon cancer-producing tissue polypeptide antigen by KAMISHOHARA, M, KAWAI, H, SAKAI, T, UCHIDA, T, TSURUO, T, OTAKE, N

“…The inhibitory effect of KRN5500, a spicamycin derivative, on the growth of hepatic metastasis of the tissue polypeptide antigen (TPA)-producing human colon…”
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Antitumor activity of a spicamycin derivative, KRN5500, and its active metabolite in tumor cells by Kamishohara, M, Kawai, H, Sakai, T, Isoe, T, Hasegawa, K, Mochizuki, J, Uchida, T, Kataoka, S, Yamaki, H, Tsuruo, T

“…KRN5500, (6-[4-Deoxy-4-(2E,4E)-tetradecadienoylglycyl]amino-L-glycero - beta-L-mannoheptopyranosyl]amino-9H-purine), was semi-synthesized in an attempt to…”
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Mechanisms of the Antimetastatic Effect in the Liver and of the Hepatocyte Injury Induced by {{alpha}}-Galactosylceramide in Mice by Nakagawa, Ryusuke, Nagafune, Ikuko, Tazunoki, Yoshiko, Ehara, Hiromi, Tomura, Hitomi, Iijima, Rieko, Motoki, Kazuhiro, Kamishohara, Masaru, Seki, Shuhji

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