Search Results - "Kamioka, Hiroki"

Functional Alterations of Multidrug Resistance-Associated Proteins 2 and 5, and Breast Cancer Resistance Protein upon Snail-Induced Epithelial–Mesenchymal Transition in HCC827 Cells by Yano, Kentaro, Todokoro, Itsuki, Kamioka, Hiroki, Tomono, Takumi, Ogihara, Takuo

“…Our previous report indicated that Snail-induced epithelial–mesenchymal transition (EMT) enhanced P-glycoprotein (P-gp) function and drug resistance to P-gp…”
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Physiological Roles of ERM Proteins and Transcriptional Regulators in Supporting Membrane Expression of Efflux Transporters as Factors of Drug Resistance in Cancer by Ogihara, Takuo, Mizoi, Kenta, Kamioka, Hiroki, Yano, Kentaro

“…One factor contributing to the malignancy of cancer cells is the acquisition of drug resistance during chemotherapy via increased expression of efflux…”
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Preliminary Evaluation of Three-Dimensional Primary Human Hepatocyte Culture System for Assay of Drug-Metabolizing Enzyme-Inducing Potential by Arakawa, Hiroshi, Kamioka, Hiroki, Jomura, Tomoko, Koyama, Satoshi, Idota, Yoko, Yano, Kentaro, Kojima, Hajime, Ogihara, Takuo

“…Drug-induced liver injury (DILI) is a common reason for withdrawal of candidate drugs from clinical trials, or of approved drugs from the market. DILI may be…”
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Drug resistance via radixin-mediated increase of P-glycoprotein membrane expression during SNAI1-induced epithelial-mesenchymal transition in HepG2 cells by Kamioka, Hiroki, Edaki, Kazue, Kasahara, Haruka, Tomono, Takumi, Yano, Kentaro, Ogihara, Takuo

“…Epithelial-mesenchymal transition (EMT) plays a role in cancer metastasis as well as in drug resistance through various mechanisms, including increased drug…”
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Effect of metformin on 18F-fluorodeoxyglucose uptake and positron emission tomographic imaging by Zhang, Xieyi, Ogihara, Takuo, Zhu, Min, Gantumur, Dolgormaa, Li, Yang, Mizoi, Kenta, Kamioka, Hiroki, Tsushima, Yoshito

“…Metformin is widely used to treat diabetes, but induces changes in glucose uptake in both normal organs and tumors. Here, we review the effects of metformin on…”
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Entinostat reverses P-glycoprotein activation in snail-overexpressing adenocarcinoma HCC827 cells by Tomono, Takumi, Machida, Tatsuya, Kamioka, Hiroki, Shibasaki, Yumi, Yano, Kentaro, Ogihara, Takuo

“…Epithelial-to-mesenchymal transition (EMT) in cancer cells facilitates tumor progression by promoting invasion and metastasis. Snail is a transcriptional…”
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P229 - P-glycoprotein activation mechanism by snail-induced epithelial-to-mesenchymal transition in lung cancer cells by Kamioka, Hiroki, Tomono, Takumi, Yano, Kentaro, Fujita, Yukiyoshi, Fujita, Atsushi, Onozato, Ryoichi, Iijima, Misa, Tsuchida, Shigeru, Arai, Takahiro, Ogihara, Takuo

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Correlations of mRNA Levels among Efflux Transporters, Transcriptional Regulators, and Scaffold Proteins in Non-Small-Cell Lung Cancer by Zhang, Xieyi, Liu, Wangyang, Edaki, Kazue, Nakazawa, Yuta, Kamioka, Hiroki, Fujita, Atsushi, Onozato, Ryoichi, Iijima, Misa, Tsuchida, Shigeru, Arai, Takahiro, Fujita, Yukiyoshi, Mizoi, Kenta, Ogihara, Takuo

“…Multidrug resistance (MDR) due to enhanced drug efflux activity of tumor cells can severely impact the efficacy of antitumor therapies. We recently showed that…”
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Evaluation of a Thiodipeptide, l-Phenylalanyl-Ψ[CS-N]-l-alanine, as a Novel Probe for Peptide Transporter 1 by Arakawa, Hiroshi, Saito, Sachi, Kanagawa, Masahiko, Kamioka, Hiroki, Yano, Kentaro, Morimoto, Kaori, Ogihara, Takuo

“…l-Phenylalanyl-Ψ[CS-N]-l-alanine (Phe-Ψ-Ala), a thiourea dipeptide, was evaluated as a probe for peptide transporter 1 (PEPT1). Uptake of Phe-Ψ-Ala in…”
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Evaluation of a Thiodipeptide, L-Phenylalanyl-Ψ[CS-N]-L-alanine, as a Novel Probe for Peptide Transporter 1 by Hiroshi ARAKAWA, Sachi SAITO, Masahiko KANAGAWA, Hiroki KAMIOKA, Kentaro YANO, Kaori MORIMOTO, Takuo OGIHARA

“…Summary: L-Phenylalanyl-Ψ[CS-N]-L-alanine (Phe-Ψ-Ala), a thiourea dipeptide, was evaluated as a probe for peptide transporter 1 (PEPT1). Uptake of Phe-Ψ-Ala in…”
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Testosterone and androstenedione are endogenous substrates of P-glycoprotein by Yano, Kentaro, Seto, Saeka, Kamioka, Hiroki, Mizoi, Kenta, Ogihara, Takuo

“…Raised brain levels of testosterone (Tes), as well as single nucleotide polymorphisms of P-glycoprotein (P-gp) that cause impaired transport function, are…”
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Effect of metformin on 18 F-fluorodeoxyglucose uptake and positron emission tomographic imaging by Zhang, Xieyi, Ogihara, Takuo, Zhu, Min, Gantumur, Dolgormaa, Li, Yang, Mizoi, Kenta, Kamioka, Hiroki, Tsushima, Yoshito

“…Metformin is widely used to treat diabetes, but induces changes in glucose uptake in both normal organs and tumors. Here, we review the effects of metformin on…”
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Interaction of Peptide Transporter 1 With D-Glucose and L-Glutamic Acid; Possible Involvement of Taste Receptors by Arakawa, Hiroshi, Ohmachi, Taichi, Ichiba, Kiko, Kamioka, Hiroki, Tomono, Takumi, Kanagawa, Masahiko, Idota, Yoko, Hatano, Yasuko, Yano, Kentaro, Morimoto, Kaori, Ogihara, Takuo

“…We investigated the influence of sweet and umami (savory) tastants on the intestinal absorption of cephalexin (CEX), a substrate of peptide transporter 1…”
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Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs by Arakawa, Hiroshi, Kamioka, Hiroki, Kanagawa, Masahiko, Hatano, Yasuko, Idota, Yoko, Yano, Kentaro, Morimoto, Kaori, Ogihara, Takuo

“…The study investigated whether quinolone antibiotics inhibit the PEPT1‐mediated uptake of its substrates. Among the quinolones examined, lomefloxacin,…”
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