Search Results - "Kaminski Schierle, Gabriele S."

Fluorescent Nanoparticles for Super-Resolution Imaging by Li, Wei, Kaminski Schierle, Gabriele S., Lei, Bingfu, Liu, Yingliang, Kaminski, Clemens F.

“…Super-resolution imaging techniques that overcome the diffraction limit of light have gained wide popularity for visualizing cellular structures with…”
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The Cellular Environment Affects Monomeric α-Synuclein Structure by Stephens, Amberley D., Zacharopoulou, Maria, Kaminski Schierle, Gabriele S.

“…The presynaptic protein α-synuclein (aSyn) is an ‘intrinsically disordered protein’ that is highly dynamic in conformation. Transient intramolecular…”
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Design of a Functionalized Metal–Organic Framework System for Enhanced Targeted Delivery to Mitochondria by Haddad, Salame, Abánades Lázaro, Isabel, Fantham, Marcus, Mishra, Ajay, Silvestre-Albero, Joaquin, Osterrieth, Johannes W. M, Kaminski Schierle, Gabriele S, Kaminski, Clemens F, Forgan, Ross S, Fairen-Jimenez, David

“…Mitochondria play a key role in oncogenesis and constitute one of the most important targets for cancer treatments. Although the most effective way to deliver…”
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Structural basis of synaptic vesicle assembly promoted by α-synuclein by Fusco, Giuliana, Pape, Tillmann, Stephens, Amberley D., Mahou, Pierre, Costa, Ana Rita, Kaminski, Clemens F., Kaminski Schierle, Gabriele S., Vendruscolo, Michele, Veglia, Gianluigi, Dobson, Christopher M., De Simone, Alfonso

“…α-synuclein (αS) is an intrinsically disordered protein whose fibrillar aggregates are the major constituents of Lewy bodies in Parkinson’s disease. Although…”
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C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction by Lautenschläger, Janin, Stephens, Amberley D., Fusco, Giuliana, Ströhl, Florian, Curry, Nathan, Zacharopoulou, Maria, Michel, Claire H., Laine, Romain, Nespovitaya, Nadezhda, Fantham, Marcus, Pinotsi, Dorothea, Zago, Wagner, Fraser, Paul, Tandon, Anurag, St George-Hyslop, Peter, Rees, Eric, Phillips, Jonathan J., De Simone, Alfonso, Kaminski, Clemens F., Schierle, Gabriele S. Kaminski

“…Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus, which forms an amphipathic alpha-helix upon membrane interaction…”
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Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity by Stephens, Amberley D., Zacharopoulou, Maria, Moons, Rani, Fusco, Giuliana, Seetaloo, Neeleema, Chiki, Anass, Woodhams, Philippa J., Mela, Ioanna, Lashuel, Hilal A., Phillips, Jonathan J., De Simone, Alfonso, Sobott, Frank, Schierle, Gabriele S. Kaminski

“…As an intrinsically disordered protein, monomeric alpha-synuclein (aSyn) occupies a large conformational space. Certain conformations lead to aggregation prone…”
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The role of water in amyloid aggregation kinetics by Stephens, Amberley D, Kaminski Schierle, Gabriele S

“…[Display omitted] •Water and protein mobility are inextricably linked and therefore water itself plays an essential role in protein function.•IDPs have a…”
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Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry Approach to Correlate Local Structure and Aggregation in α‑Synuclein by Seetaloo, Neeleema, Zacharopoulou, Maria, Stephens, Amberley D., Kaminski Schierle, Gabriele S., Phillips, Jonathan J.

“…In Parkinson’s disease and other synucleinopathies, α-synuclein misfolds and aggregates. Its intrinsically disordered nature, however, causes it to adopt…”
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Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy by Pinotsi, Dorothea, Buell, Alexander K, Galvagnion, Celine, Dobson, Christopher M, Kaminski Schierle, Gabriele S, Kaminski, Clemens F

“…The self-assembly of normally soluble proteins into fibrillar amyloid structures is associated with a range of neurodegenerative disorders, such as Parkinson’s…”
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Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies by Hardenberg, Maarten C, Sinnige, Tessa, Casford, Sam, Dada, Samuel T, Poudel, Chetan, Robinson, Elizabeth A, Fuxreiter, Monika, Kaminksi, Clemens F, Kaminski Schierle, Gabriele S, Nollen, Ellen A A, Dobson, Christopher M, Vendruscolo, Michele

“…Misfolded α-synuclein is a major component of Lewy bodies, which are a hallmark of Parkinson's disease (PD). A large body of evidence shows that α-synuclein…”
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Fluorescence Self-Quenching from Reporter Dyes Informs on the Structural Properties of Amyloid Clusters Formed in Vitro and in Cells by Chen, WeiYue, Young, Laurence J, Lu, Meng, Zaccone, Alessio, Ströhl, Florian, Yu, Na, Kaminski Schierle, Gabriele S, Kaminski, Clemens F

“…The characterization of the aggregation kinetics of protein amyloids and the structural properties of the ensuing aggregates are vital in the study of the…”
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A Label-Free, Quantitative Assay of Amyloid Fibril Growth Based on Intrinsic Fluorescence by Pinotsi, Dorothea, Buell, Alexander K., Dobson, Christopher M., Kaminski Schierle, Gabriele S., Kaminski, Clemens F.

“…Kinetic assay of seeded growth: The graph shows the variation in intrinsic fluorescence intensity of amyloid fibrils. Fluorescence increases during the seeded…”
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Short hydrogen bonds enhance nonaromatic protein-related fluorescence by Stephens, Amberley D., Qaisrani, Muhammad Nawaz, Ruggiero, Michael T., Mirón, Gonzalo Díaz, Morzan, Uriel N., Lebrero, Mariano C. González, Jones, Saul T. E., Poli, Emiliano, Bond, Andrew D., Woodhams, Philippa J., Kleist, Elyse M., Grisanti, Luca, Gebauer, Ralph, Zeitler, J. Axel, Credgington, Dan, Hassanali, Ali, Schierle, Gabriele S. Kaminski

“…Fluorescence in biological systems is usually associated with the presence of aromatic groups. Here, by employing a combined experimental and computational…”
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Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells by Novo, Clara Lopes, Wong, Emily V., Hockings, Colin, Poudel, Chetan, Sheekey, Eleanor, Wiese, Meike, Okkenhaug, Hanneke, Boulton, Simon J., Basu, Srinjan, Walker, Simon, Kaminski Schierle, Gabriele S., Narlikar, Geeta J., Rugg-Gunn, Peter J.

“…Heterochromatin maintains genome integrity and function, and is organised into distinct nuclear domains. Some of these domains are proposed to form by phase…”
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Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox by Avezov, Edward, Cross, Benedict C S, Kaminski Schierle, Gabriele S, Winters, Mikael, Harding, Heather P, Melo, Eduardo Pinho, Kaminski, Clemens F, Ron, David

“…Interfering with disulfide bond formation impedes protein folding and promotes endoplasmic reticulum (ER) stress. Due to limitations in measurement techniques,…”
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The carbonyl-lock mechanism underlying non-aromatic fluorescence in biological matter by Mirón, Gonzalo Díaz, Semelak, Jonathan A., Grisanti, Luca, Rodriguez, Alex, Conti, Irene, Stella, Martina, Velusamy, Jayaramakrishnan, Seriani, Nicola, Došlić, Nadja, Rivalta, Ivan, Garavelli, Marco, Estrin, Dario A., Kaminski Schierle, Gabriele S., González Lebrero, Mariano C., Hassanali, Ali, Morzan, Uriel N.

“…Challenging the basis of our chemical intuition, recent experimental evidence reveals the presence of a new type of intrinsic fluorescence in biomolecules that…”
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Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons by Pinotsi, Dorothea, Michel, Claire H., Buell, Alexander K., Laine, Romain F., Mahou, Pierre, Dobson, Christopher M., Kaminski, Clemens F., Schierle, Gabriele S. Kaminski

“…New strategies for visualizing self-assembly processes at the nanoscale give deep insights into the molecular origins of disease. An example is the…”
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Sea cucumber-derived extract can protect skin cells from oxidative DNA damage and mitochondrial degradation, and promote wound healing by Mazumder, Bismoy, Lu, Meng, Rahmoune, Hassan, Fernandez-Villegas, Ana, Ward, Edward, Wang, Min, Ren, Jiaoyan, Yu, Yi, Zhang, Ting, Liang, Ming, Li, Wenzhi, Läubli, Nino F., Kaminski, Clemens F., Kaminski Schierle, Gabriele S.

“…Our skin serves as the primary barrier against external environmental insults, the latter of which can cause oxidative stress within cells, while various…”
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A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. elegans by Jung, Raimund, Lechler, Marie C, Fernandez-Villegas, Ana, Chung, Chyi Wei, Jones, Harry C, Choi, Yoon Hee, Thompson, Maximilian A, Rödelsperger, Christian, Röseler, Waltraud, Kaminski Schierle, Gabriele S, Sommer, Ralf J, David, Della C

“…During aging, proteostasis capacity declines and distinct proteins become unstable and can accumulate as protein aggregates inside and outside of cells. Both…”
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CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation by Davies, Tim, Kodera, Noriyuki, Kaminski Schierle, Gabriele S, Rees, Eric, Erdelyi, Miklos, Kaminski, Clemens F, Ando, Toshio, Mishima, Masanori

“…Centralspindlin, a constitutive 2:2 heterotetramer of MKLP1 (a kinesin-6) and the non-motor subunit CYK4, plays important roles in cytokinesis. It is crucial…”
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