Search Results - "Kaminski, Robert W."

Bioactivity and efficacy of a hyperimmune bovine colostrum product- Travelan, against shigellosis in a non-Human primate model (Macaca mulatta) by Islam, Dilara, Ruamsap, Nattaya, Imerbsin, Rawiwan, Khanijou, Patchariya, Gonwong, Siriphan, Wegner, Matthew D, McVeigh, Annette, Poly, Frédéric M, Crawford, John M, Swierczewski, Brett E, Kaminski, Robert W, Laird, Renee M

“…Infectious diarrhea is a World Health Organization public health priority area due to the lack of effective vaccines and an accelerating global antimicrobial…”
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Evaluation of the reactogenicity, adjuvanticity and antigenicity of LT(R192G) and LT(R192G/L211A) by intradermal immunization in mice by Maciel, Jr, Milton, Smith, Mark, Poole, Steven T, Laird, Renee M, Rollenhagen, Julianne E, Kaminski, Robert W, Wenzel, Heather, Bourgeois, A Louis, Savarino, Stephen J

“…The development of an effective subunit vaccine is frequently complicated by the difficulty of eliciting protective immune responses, often requiring the…”
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Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protection by Talaat, Kawsar R., Alaimo, Cristina, Martin, Patricia, Bourgeois, A. Louis, Dreyer, Anita M., Kaminski, Robert W., Porter, Chad K., Chakraborty, Subhra, Clarkson, Kristen A., Brubaker, Jessica, Elwood, Daniel, Frölich, Rahel, DeNearing, Barbara, Weerts, Hailey, Feijoo, Brittany L., Halpern, Jane, Sack, David, Riddle, Mark S., Fonck, Veronica Gambillara

“…Shigellosis is a major cause of moderate to severe diarrhoea and dysentery in children under 5 years of age in low and middle-income countries. The Flexyn2a…”
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Vaccines for Protecting Infants from Bacterial Causes of Diarrheal Disease by Walker, Richard, Kaminski, Robert W, Porter, Chad, Choy, Robert K M, White, Jessica A, Fleckenstein, James M, Cassels, Fred, Bourgeois, Louis

“…The global diarrheal disease burden for , enterotoxigenic (ETEC), and is estimated to be 88M, 75M, and 75M cases annually, respectively. A vaccine against this…”
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Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score by Porter, Chad K, Lynen, Amanda, Riddle, Mark S, Talaat, Kawsar, Sack, David, Gutiérrez, Ramiro L, McKenzie, Robin, DeNearing, Barbara, Feijoo, Brittany, Kaminski, Robert W, Taylor, David N, Kirkpatrick, Beth D, Bourgeois, A Louis

“…Since 1946 the controlled human infection model (CHIM) for Shigella has been used to improve understanding of disease pathogenesis, describe clinical and…”
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Immune response characterization in a human challenge study with a Shigella flexneri 2a bioconjugate vaccine by Clarkson, Kristen A., Talaat, Kawsar R., Alaimo, Cristina, Martin, Patricia, Bourgeois, A. Louis, Dreyer, Anita, Porter, Chad K., Chakraborty, Subhra, Brubaker, Jessica, Elwood, Daniel, Frölich, Rahel, DeNearing, Barbara, Weerts, Hailey P., Feijoo, Brittany, Halpern, Jane, Sack, David, Riddle, Mark S., Fonck, Veronica Gambillara, Kaminski, Robert W.

“…Diarrheal diseases are a leading cause of global morbidity and mortality affecting all ages, but especially children under the age of five in resource-limited…”
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Development of the Shigella flexneri 2a, 3a, 6, and S. sonnei artificial Invaplex (Invaplex AR ) vaccines by Turbyfill, K Ross, Clarkson, Kristen A, Oaks, Edwin V, Zurawski, Daniel V, Vortherms, Anthony R, Kaminski, Robert W

“…The artificial invasin complex (Invaplex ) vaccine is a subunit approach that effectively induces robust immunogenicity directed to serotype-specific…”
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Efficacy, safety, and immunogenicity of the Shigella sonnei 1790GAHB GMMA candidate vaccine: Results from a phase 2b randomized, placebo-controlled challenge study in adults by Frenck, Robert W., Conti, Valentino, Ferruzzi, Pietro, Ndiaye, Augustin G.W., Parker, Susan, McNeal, Monica Malone, Dickey, Michelle, Granada, Juan Paolo, Cilio, Giulia Luna, De Ryck, Iris, Necchi, Francesca, Suvarnapunya, Akamol E., Rossi, Omar, Acquaviva, Alessandra, Chandrasekaran, Lakshmi, Clarkson, Kristen A., Auerbach, Joachim, Marchetti, Elisa, Kaminski, Robert W., Micoli, Francesca, Rappuoli, Rino, Saul, Allan, Martin, Laura B., Podda, Audino

“…Shigellosis accounts for substantial morbidity and mortality worldwide and is the second most common cause of moderate and severe diarrhoea in children. This…”
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Immunization of Rabbits with a Quadrivalent Shigella Bioconjugate Vaccine Induces Functional Antibodies Reactive with Shigella Isolates from Kenya by Odundo, Elizabeth A, Weerts, Hailey P, Musila, Lillian, Ogonda, Lilian, Dreyer, Anita M, Schneider, Joerg, Carranza, Paula, Kaminski, Robert W

“…Diarrheal diseases are a leading cause of global morbidity and mortality, disproportionately affecting children in resource-limited settings. Although…”
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From Concept to Clinical Product: A Brief History of the Novel Shigella Invaplex Vaccine's Refinement and Evolution by Turbyfill, K Ross, Clarkson, Kristen A, Oaks, Edwin V, Kaminski, Robert W

“…The invasin complex or Invaplex vaccine is a unique subunit approach to generate a protective immune response. Invaplex is a large, macromolecular complex…”
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Shigella -Specific Immune Profiles Induced after Parenteral Immunization or Oral Challenge with Either Shigella flexneri 2a or Shigella sonnei by Clarkson, Kristen A, Porter, Chad K, Talaat, Kawsar R, Frenck, Jr, Robert W, Alaimo, Cristina, Martin, Patricia, Bourgeois, A Louis, Kaminski, Robert W

“…spp. are a leading cause of diarrhea-associated global morbidity and mortality. Development and widespread implementation of an efficacious vaccine remain the…”
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Immune Response Characterization after Controlled Infection with Lyophilized Shigella sonnei 53G by Clarkson, Kristen A., Frenck, Robert W., Dickey, Michelle, Suvarnapunya, Akamol E., Chandrasekaran, Lakshmi, Weerts, Hailey P., Heaney, Christopher D., McNeal, Monica, Detizio, Kate, Parker, Susan, Hoeper, Amy, Bourgeois, August L., Porter, Chad K., Venkatesan, Malabi M., Kaminski, Robert W.

“…Correlate(s) of immunity have yet to be defined for shigellosis. As previous disease protects against subsequent infection in a serotype-specific manner,…”
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IpaD Localizes to the Tip of the Type III Secretion System Needle of Shigella flexneri by Espina, Marianela, Olive, Andrew J, Kenjale, Roma, Moore, David S, Ausar, S. Fernando, Kaminski, Robert W, Oaks, Edwin V, Middaugh, C. Russell, Picking, William D, Picking, Wendy L

“…Shigella flexneri, the causative agent of shigellosis, is a gram-negative bacterial pathogen that initiates infection by invading cells within the colonic…”
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Putative correlates of protection against shigellosis assessing immunomarkers across responses to S. sonnei investigational vaccine by Conti, Valentino, Rossi, Omar, Clarkson, Kristen A., Mancini, Francesca, Nakakana, Usman N., Sarakinou, Eleanna, Callegaro, Andrea, Ferruzzi, Pietro, Acquaviva, Alessandra, Arora, Ashwani Kumar, Marchetti, Elisa, Necchi, Francesca, Frenck, Robert W., Martin, Laura B., Kaminski, Robert W., Podda, Audino, Micoli, Francesca

“…Shigella spp. are a leading bacterial cause of diarrhea. No widely licensed vaccines are available and there is no generally accepted correlate of protection…”
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Invaplex functions as an intranasal adjuvant for subunit and DNA vaccines co-delivered in the nasal cavity of nonhuman primates by Camp, Jeremy V., Wilson, Robert L., Singletary, Morgan, Blanchard, James L., Aldovini, Anna, Kaminski, Robert W., Oaks, Edwin V., Kozlowski, Pamela A.

“…Development of intranasal vaccines for HIV-1 and other mucosal pathogens has been hampered by the lack of adjuvants that can be given safely to humans. We have…”
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Establishment of a Controlled Human Infection Model with a Lyophilized Strain of Shigella sonnei 53G by Frenck, Robert W., Dickey, Michelle, Suvarnapunya, Akamol E., Chandrasekaran, Lakshmi, Kaminski, Robert W., Clarkson, Kristen A., McNeal, Monica, Lynen, Amanda, Parker, Susan, Hoeper, Amy, Mani, Sachin, Fix, Alan, Maier, Nicole, Venkatesan, Malabi M., Porter, Chad K.

“…Controlled human infection models (CHIMs) are invaluable tools utilized to understand the human response to infection, potentially leading to protective immune…”
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Virulence, Inflammatory Potential, and Adaptive Immunity Induced by Shigella flexneri msbB Mutants by Ranallo, Ryan T, Kaminski, Robert W, George, Tonia, Kordis, Alexis A, Chen, Qing, Szabo, Kathleen, Venkatesan, Malabi M

“…The ability of genetically detoxified lipopolysaccharide (LPS) to stimulate adaptive immune responses is an ongoing area of investigation with significant…”
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A broadly immunogenic polyvalent Shigella multiepitope fusion antigen protein protects against Shigella sonnei and Shigella flexneri lethal pulmonary challenges in mice by Li, Siqi, Anvari, Shaghayegh, Ptacek, Galen, Upadhyay, Ipshita, Kaminski, Robert W., Sack, David A., Zhang, Weiping

“…ABSTRACT There are no licensed vaccines for Shigella , a leading cause of children’s diarrhea and a common etiology of travelers’ diarrhea. To develop a…”
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Safety and Immunogenicity of a Candidate Bioconjugate Vaccine against Shigella flexneri 2a Administered to Healthy Adults: a Single-Blind, Randomized Phase I Study by Riddle, Mark S, Kaminski, Robert W, Di Paolo, Claudio, Porter, Chad K, Gutierrez, Ramiro L, Clarkson, Kristen A, Weerts, Hailey E, Duplessis, Christopher, Castellano, Amy, Alaimo, Cristina, Paolino, Kristopher, Gormley, Robert, Gambillara Fonck, Veronica

“…Several candidate vaccines against Shigella spp. are in development, but the lack of a clear correlate of protection from challenge with the induction of…”
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Mucosal Adjuvant Properties of the Shigella Invasin Complex by Kaminski, Robert W, Turbyfill, K. Ross, Oaks, Edwin V

“…The Shigella invasin complex (Invaplex) is an effective mucosal vaccine capable of protecting against Shigella challenge in animal models. The major antigenic…”
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