Search Results - "Kaminski, Rafal M."

Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? by Klein, Pavel, Friedman, Alon, Hameed, Mustafa Q., Kaminski, Rafal M., Bar‐Klein, Guy, Klitgaard, Henrik, Koepp, Mathias, Jozwiak, Sergiusz, Prince, David A., Rotenberg, Alexander, Twyman, Roy, Vezzani, Annamaria, Wong, Michael, Löscher, Wolfgang

“…Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults such as traumatic brain injury (TBI), cerebrovascular accidents (CVA),…”
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Neuroinflammatory targets and treatments for epilepsy validated in experimental models by Aronica, Eleonora, Bauer, Sebastian, Bozzi, Yuri, Caleo, Matteo, Dingledine, Raymond, Gorter, Jan A., Henshall, David C., Kaufer, Daniela, Koh, Sookyong, Löscher, Wolfgang, Louboutin, Jean‐Pierre, Mishto, Michele, Norwood, Braxton A., Palma, Eleonora, Poulter, Michael O., Terrone, Gaetano, Vezzani, Annamaria, Kaminski, Rafal M.

“…Summary A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy…”
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Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment by Klitgaard, Henrik, Matagne, Alain, Nicolas, Jean‐Marie, Gillard, Michel, Lamberty, Yves, De Ryck, Marc, Kaminski, Rafal M., Leclercq, Karine, Niespodziany, Isabelle, Wolff, Christian, Wood, Martyn, Hannestad, Jonas, Kervyn, Sophie, Kenda, Benoit

“…Summary Despite availability of effective antiepileptic drugs (AEDs), many patients with epilepsy continue to experience refractory seizures and adverse…”
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Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy by Mazzuferi, Manuela, Kumar, Gaurav, van Eyll, Jonathan, Danis, Benedicte, Foerch, Patrik, Kaminski, Rafal M.

“…Objective Epigenetic mechanisms involved in transcriptional regulation of multiple molecular pathways are potentially attractive therapeutic interventions for…”
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Rapid epileptogenesis in the mouse pilocarpine model: Video-EEG, pharmacokinetic and histopathological characterization by Mazzuferi, Manuela, Kumar, Gaurav, Rospo, Chiara, Kaminski, Rafal M.

“…Temporal lobe epilepsy (TLE) is the most common form of drug-resistant epilepsy and several rodent models allow studying the pathophysiology of this disorder…”
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n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis by Frigerio, Federica, Pasqualini, Giulia, Craparotta, Ilaria, Marchini, Sergio, van Vliet, Erwin A, Foerch, Patrick, Vandenplas, Catherine, Leclercq, Karin, Aronica, Eleonora, Porcu, Luca, Pistorius, Kimberly, Colas, Romain A, Hansen, Trond V, Perretti, Mauro, Kaminski, Rafal M, Dalli, Jesmond, Vezzani, Annamaria

“…Frigerio et al. report that pro-resolving mechanisms of neuroinflammation are dysregulated during epileptogenesis, thereby promoting a persistent…”
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Discovery of (R)‑N‑Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS‑1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo by Abram, Michał, Jakubiec, Marcin, Reeb, Katelyn, Cheng, Mary Hongying, Gedschold, Robin, Rapacz, Anna, Mogilski, Szczepan, Socała, Katarzyna, Nieoczym, Dorota, Szafarz, Małgorzata, Latacz, Gniewomir, Szulczyk, Bartłomiej, Kalinowska-Tłuścik, Justyna, Gawel, Kinga, Esguerra, Camila V., Wyska, Elżbieta, Müller, Christa E., Bahar, Ivet, Fontana, Andréia C. K., Wlaź, Piotr, Kamiński, Rafał M., Kamiński, Krzysztof

“…( R )-7 [( R )-AS-1] showed broad-spectrum antiseizure activity across in vivo mouse seizure models: maximal electroshock (MES), 6 Hz (32/44 mA), acute…”
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TRPV1 channel in the pathophysiology of epilepsy and its potential as a molecular target for the development of new antiseizure drug candidates by Socała, Katarzyna, Jakubiec, Marcin, Abram, Michał, Mlost, Jakub, Starowicz, Katarzyna, Kamiński, Rafał M., Ciepiela, Katarzyna, Andres-Mach, Marta, Zagaja, Mirosław, Metcalf, Cameron S., Zawadzki, Przemysław, Wlaź, Piotr, Kamiński, Krzysztof

“…Identification of transient receptor potential cation channel, subfamily V member 1 (TRPV1), also known as capsaicin receptor, in 1997 was a milestone…”
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The Search for New Anticonvulsants in a Group of (2,5-Dioxopyrrolidin-1-yl)(phenyl)Acetamides with Hybrid Structure-Synthesis and In Vivo/In Vitro Studies by Abram, Michał, Jakubiec, Marcin, Rapacz, Anna, Mogilski, Szczepan, Latacz, Gniewomir, Kamiński, Rafał M, Kamiński, Krzysztof

“…Epilepsy belongs to the most common and debilitating neurological disorders with multifactorial pathophysiology and a high level of drug resistance. Therefore,…”
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KA‐104, a new multitargeted anticonvulsant with potent antinociceptive activity in preclinical models by Kamiński, Krzysztof, Mogilski, Szczepan, Abram, Michał, Rapacz, Anna, Latacz, Gniewomir, Szulczyk, Bartłomiej, Walczak, Maria, Kuś, Kamil, Matyjaszczyk, Karolina, Kamiński, Rafał M.

“…Objective The main objective of the present work was to assess the utility of KA‐104 as potential therapy for drug‐resistant seizures and neuropathic pain, and…”
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A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target by Srivastava, Prashant K., van Eyll, Jonathan, Godard, Patrice, Mazzuferi, Manuela, Delahaye-Duriez, Andree, Van Steenwinckel, Juliette, Gressens, Pierre, Danis, Benedicte, Vandenplas, Catherine, Foerch, Patrik, Leclercq, Karine, Mairet-Coello, Georges, Cardenas, Alvaro, Vanclef, Frederic, Laaniste, Liisi, Niespodziany, Isabelle, Keaney, James, Gasser, Julien, Gillet, Gaelle, Shkura, Kirill, Chong, Seon-Ah, Behmoaras, Jacques, Kadiu, Irena, Petretto, Enrico, Kaminski, Rafal M., Johnson, Michael R.

“…The identification of drug targets is highly challenging, particularly for diseases of the brain. To address this problem, we developed and experimentally…”
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Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides by Abram, Michał, Jakubiec, Marcin, Rapacz, Anna, Mogilski, Szczepan, Latacz, Gniewomir, Szulczyk, Bartłomiej, Szafarz, Małgorzata, Socała, Katarzyna, Nieoczym, Dorota, Wyska, Elżbieta, Wlaź, Piotr, Kamiński, Rafał M, Kamiński, Krzysztof

“…We report herein a series of water-soluble analogues of previously described anticonvulsants and their detailed in vivo and in vitro characterization. The…”
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Novel Alaninamide Derivatives with Drug-like Potential for Development as Antiseizure and Antinociceptive TherapiesIn Vitro and In Vivo Characterization by Jakubiec, Marcin, Abram, Michał, Zagaja, Mirosław, Andres-Mach, Marta, Szala-Rycaj, Joanna, Latacz, Gniewomir, Honkisz-Orzechowska, Ewelina, Mogilski, Szczepan, Kubacka, Monika, Szafarz, Małgorzata, Pociecha, Krzysztof, Przejczowska-Pomierny, Katarzyna, Wyska, Elżbieta, Socała, Katarzyna, Nieoczym, Dorota, Szulczyk, Bartłomiej, Wlaź, Piotr, Metcalf, Cameron S., Wilcox, Karen, Kamiński, Rafał M., Kamiński, Krzysztof

“…In the present study, a series of original alaninamide derivatives have been designed applying a combinatorial chemistry approach, synthesized, and…”
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Inhibition of CHIT1 as a novel therapeutic approach in idiopathic pulmonary fibrosis by Sklepkiewicz, Piotr, Dymek, Barbara A., Mlacki, Michal, Koralewski, Robert, Mazur, Marzena, Nejman-Gryz, Patrycja, Korur, Serdar, Zagozdzon, Agnieszka, Rymaszewska, Aleksandra, von der Thüsen, Jan H., Siwińska, Anna M., Güner, Nazan Cemre, Cheda, Łukasz, Paplinska-Goryca, Magdalena, Proboszcz, Małgorzata, van den Bosch, Thierry P.P., Górska, Katarzyna, Golab, Jakub, Kamiński, Rafał M., Krenke, Rafał, Golebiowski, Adam, Dzwonek, Karolina, Dobrzanski, Pawel

“…Idiopathic pulmonary fibrosis (IPF) is a progressive and eventually fatal lung disease with a complex etiology. Approved drugs, nintedanib and pirfenidone,…”
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Discovery and Profiling of New Multimodal Phenylglycinamide Derivatives as Potent Antiseizure and Antinociceptive Drug Candidates by Jakubiec, Marcin, Abram, Michał, Zagaja, Mirosław, Socała, Katarzyna, Panic, Vanja, Latacz, Gniewomir, Mogilski, Szczepan, Szafarz, Małgorzata, Szala-Rycaj, Joanna, Saunders, Jerry, West, Peter J., Nieoczym, Dorota, Przejczowska-Pomierny, Katarzyna, Szulczyk, Bartłomiej, Krupa, Anna, Wyska, Elżbieta, Wlaź, Piotr, Metcalf, Cameron S., Wilcox, Karen, Andres-Mach, Marta, Kamiński, Rafał M., Kamiński, Krzysztof

“…We developed a focused series of original phenyl-glycinamide derivatives which showed potent activity across in vivo mouse seizure models, namely, maximal…”
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Inhibiting Epileptiform Activity in Cognitive Disorders: Possibilities for a Novel Therapeutic Approach by Horvath, Andras Attila, Csernus, Emoke Anna, Lality, Sara, Kaminski, Rafal M., Kamondi, Anita

“…Cognitive impairment is a common and seriously debilitating symptom of various mental and neurological disorders including autism, attention deficit…”
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Inhibition of glutamate decarboxylase (GAD) by ethyl ketopentenoate (EKP) induces treatment-resistant epileptic seizures in zebrafish by Zhang, Yifan, Vanmeert, Michiel, Siekierska, Aleksandra, Ny, Annelii, John, Jubi, Callewaert, Geert, Lescrinier, Eveline, Dehaen, Wim, de Witte, Peter A. M., Kaminski, Rafal M.

“…Epilepsy is a chronic brain disorder characterized by recurrent seizures due to abnormal, excessive and synchronous neuronal activities in the brain. It…”
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Asymmetric synthesis and in vivo/in vitro characterization of new hybrid anticonvulsants derived from (2,5-dioxopyrrolidin-1-yl)phenylacetamides by Abram, Michał, Rapacz, Anna, Latacz, Gniewomir, Szulczyk, Bartłomiej, Kalinowska-Tłuścik, Justyna, Otto-Ślusarczyk, Dagmara, Struga, Marta, Kamiński, Rafał M., Kamiński, Krzysztof

“…[Display omitted] •New hybrid anticonvulsants were obtained applying the multistep asymmetric procedure.•X-ray crystallography was used to solve the spatial…”
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Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis by Fritsch, Brita, Reis, Janine, Gasior, Maciej, Kaminski, Rafal M, Rogawski, Michael A

“…Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotransmission in brain regions, such as the amygdala and…”
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Anticonvulsant and antiepileptogenic effects of system xc− inactivation in chronic epilepsy models by Leclercq, Karine, Liefferinge, Joeri Van, Albertini, Giulia, Neveux, Michel, Dardenne, Sylvia, Mairet‐Coello, Georges, Vandenplas, Catherine, Deprez, Tania, Chong, Seon‐Ah, Foerch, Patrik, Bentea, Eduard, Sato, Hideyo, Maher, Pamela, Massie, Ann, Smolders, Ilse, Kaminski, Rafal M.

“…Objective The cystine/glutamate antiporter system xc− could represent a new target for antiepileptogenic treatments due to its crucial roles in glutamate…”
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