Search Results - "Kamino, Hiroki"

Generation of antagonistic monoclonal antibodies against the neoepitope of active mouse interleukin (IL)-18 cleaved by inflammatory caspases by Uchida, Yuki, Nariai, Yuko, Obayashi, Eiji, Tajima, Yoshitsugu, Koga, Tomohiro, Kawakami, Atsushi, Urano, Takeshi, Kamino, Hiroki

“…Interleukin 18 (IL-18) is a member of the IL-1 family and plays an important role in both the innate and acquired immune systems. It is constitutively…”
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Possible role of p53/Mieap‐regulated mitochondrial quality control as a tumor suppressor in human breast cancer by Gaowa, Siqin, Futamura, Manabu, Tsuneki, Masayuki, Kamino, Hiroki, Tajima, Jesse Y., Mori, Ryutaro, Arakawa, Hirofumi, Yoshida, Kazuhiro

“…Mitochondria‐eating protein (Mieap), encoded by a p53‐target gene, plays an important role in mitochondrial quality control (MQC). Mieap has been reported to…”
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Generation of the novel anti-FXYD5 monoclonal antibody and its application to the diagnosis of pancreatic and lung cancer by Hotta, Takamasa, Nariai, Yuko, Kajitani, Naoyo, Kadota, Kyuichi, Maruyama, Riruke, Tajima, Yoshitsugu, Isobe, Takeshi, Kamino, Hiroki, Urano, Takeshi

“…Despite recent advances in cancer treatments, pancreatic cancer has a dismal prognosis globally. Early detection of cancer cells and effective treatments for…”
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p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers by Sano, Hitoya, Futamura, Manabu, Gaowa, Siqin, Kamino, Hiroki, Nakamura, Yasuyuki, Yamaguchi, Kazuya, Tanaka, Yoshihiro, Yasufuku, Itaru, Nakakami, Akira, Arakawa, Hirofumi, Yoshida, Kazuhiro

“…Mitochondria-eating protein (Mieap) plays a critical role in mitochondrial quality control (MQC) and functions as a p53-inducible tumor suppressor. This study…”
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BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria by Nakamura, Yasuyuki, Kitamura, Noriaki, Shinogi, Daisuke, Yoshida, Masaki, Goda, Olga, Murai, Ryuya, Kamino, Hiroki, Arakawa, Hirofumi

“…Mieap, a p53-inducible protein, controls mitochondrial quality by repairing unhealthy mitochondria. During repair, Mieap induces the accumulation of…”
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Precise epitope determination of the anti-vimentin monoclonal antibody V9 by Tomiyama, Lucia, Kamino, Hiroki, Fukamachi, Hiroki, Urano, Takeshi

“…Vimentin is a type III intermediate filament protein that is typically expressed in mesenchymal cells. Overexpression of vimentin is frequently observed in…”
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Kinetics of Anti-SARS-CoV-2 Antibody Response Following Two Doses of the BNT162b2 mRNA Vaccine: A Japanese Single-Center Primary Care Clinic Report Involving Volunteers and Patients with Autoimmune Disease by Sugiura, Tomoko, Sugiura, Hiroaki, Kato, Hiroaki, Nariai, Yuko, Mizumoto, Yuuki, Hanada, Kozue, Takahashi, Rieko, Hinotubo, Yukari, Tanaka, Naoko, Sasaki, Mutsumi, Eguchi, Haruki, Kamino, Hiroki, Urano, Takeshi

“…Despite the promising effectiveness of the coronavirus disease 2019 vaccination using an mRNA vaccine, the short efficacy duration and some poor responses to…”
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Possible role of semaphorin 3F, a candidate tumor suppressor gene at 3p21.3, in p53-regulated tumor angiogenesis suppression by FUTAMURA, Manabu, KAMINO, Hiroki, MIYAMOTO, Yuji, KITAMURA, Noriaki, NAKAMURA, Yasuyuki, OHNISHI, Shiho, MASUDA, Yoshiko, ARAKAWA, Hirofumi

“…Although the regulation of tumor angiogenesis is believed to be one of the core functions of p53, the mechanism still remains to be elucidated. Here, we report…”
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The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage by Masuda, Yoshiko, Futamura, Manabu, Kamino, Hiroki, Nakamura, Yasuyuki, Kitamura, Noriaki, Ohnishi, Shiho, Miyamoto, Yuji, Ichikawa, Hitoshi, Ohta, Tsutomu, Ohki, Misao, Kiyono, Tohru, Egami, Hiroshi, Baba, Hideo, Arakawa, Hirofumi

“…The tumor suppressor p53 plays a crucial role in the cellular response to DNA damage by transcriptional activation of numerous downstream genes. Although a…”
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B‐cell linker protein prevents aneuploidy by inhibiting cytokinesis by Kamino, Hiroki, Futamura, Manabu, Nakamura, Yasuyuki, Kitamura, Noriaki, Kabu, Koki, Arakawa, Hirofumi

“…Aneuploidy is a hallmark of human cancers. Although the maintenance of genomic integrity by p53 is important in preventing aneuploidy, its mechanism remains to…”
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Identification of p53–46F as a super p53 with an enhanced ability to induce p53‐dependent apoptosis by Nakamura, Yasuyuki, Futamura, Manabu, Kamino, Hiroki, Yoshida, Koji, Nakamura, Yusuke, Arakawa, Hirofumi

“…More than half of human cancers contain mutations in the tumor suppressor protein p53, most of which accumulate in the DNA binding domain of the protein. Here…”
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Searching for Genes Involved in Arteriosclerosis: Proteomic Analysis of Cultured Human Umbilical Vein Endothelial Cells Undergoing Replicative Senescence by Kamino, Hiroki, Hiratsuka, Masaharu, Toda, Tosifusa, Nishigaki, Ryuichi, Osaki, Mitsuhiko, Ito, Hisao, Inoue, Toshiaki, Oshimura, Mitsuo

“…It is known that replicative senescence of endothelium in vivo contributes at least partially to age-related vascular disorders such as arteriosclerosis…”
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Screening of a Panel of Low Molecular Weight Compounds That Inhibit Synovial Fibroblast Invasion in Rheumatoid Arthritis by Sugiura, Tomoko, Kamino, Hiroki, Nariai, Yuko, Murakawa, Yohko, Kondo, Masahiro, Kawakami, Makoto, Ikeda, Noboru, Uchio, Yuji, Urano, Takeshi

“…Increased invasion of synovial fibroblasts and their involvement in cartilage damage are characteristic phenotypes of rheumatoid arthritis (RA). To identify…”
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Identification of a 600-kb region on human chromosome 1q42.3 inducing cellular senescence by YAWATA, Toshio, KAMINO, Hiroki, KUGOH, Hiroyuki, KATOH, Motonobu, NOMURA, Nobuo, OISHI, Michio, HORIKAWA, Izumi, BARRETT, J. Carl, OSHIMURA, Mitsuo

“…The introduction of a human chromosome 1 via microcell-mediated chromosome transfer (MMCT) induces the cellular senescence in mouse melanoma B16-F10 cells. The…”
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Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function by Mu, Jingxi, Maeda, Keiko, Ohashi, Ayako, Urano, Takeshi, Nariai, Yuko, Kamino, Hiroki, Nakamura, Masanao, Yamamura, Takeshi, Sawada, Tsunaki, Ishikawa, Eri, Murate, Kentaro, Yamamoto, Kenta, Hirose, Takashi, Furukawa, Kazuhiro, Fujishiro, Mitsuhiro, Kawashima, Hiroki

“…Background Numerous biological interventions and small molecules are used to treat Crohn’s disease; however, the effectiveness of these treatments varies…”
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Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18 by Nariai, Yuko, Kamino, Hiroki, Obayashi, Eiji, Kato, Hiroaki, Sakashita, Gyosuke, Sugiura, Tomoko, Migita, Kiyoshi, Koga, Tomohiro, Kawakami, Atsushi, Sakamoto, Kazuma, Kadomatsu, Kenji, Nakakido, Makoto, Tsumoto, Kouhei, Urano, Takeshi

“…Interleukin‐18 (IL‐18) is a pro-inflammatory cytokine that evokes both innate and acquired immune responses. IL-18 is initially synthesized as an inactive…”
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The nuclear receptor constitutive active/androstane receptor arrests DNA-damaged human hepatocellular carcinoma Huh7 cells at the G2/M phase by Kamino, Hiroki, Negishi, Masahiko

“…Here, we have demonstrated that xenobiotic activation of the nuclear receptor (CAR, NR1I3) can result in arresting DNA‐damaged human hepatocellular carcinoma…”
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Abstract 2465: p53-dependent and independent functions of Mieap by Nakamura, Yasuyuki, Kamino, Hiroki, Saito, Yuri, Sano, Hitoya, Arakawa, Hirofumi

“…Abstract Mieap, a p53-inducible protein, plays a pivotal role in mitochondrial quality control (MQC) by repairing or eliminating unhealthy mitochondria1-4. To…”
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Abstract LB-131: Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria by Nakamura, Yasuyuki, Kamino, Hiroki, Sano, Hitoya, Arakawa, Hirofumi

“…Abstract The accumulation of unhealthy mitochondria results in mitochondrial dysfunction, which has been implicated in aging, cancer, and a variety of…”
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Abstract 318: Specific role of Mieap α in Mieap-induced vacuole generation through an interaction with UVRAG by Nakamura, Yasuyuki, Kamino, Hiroki, Saito, Yuri, Kitamura, Noriaki, Sano, Hitoya, Arakawa, Hirofumi

“…Abstract Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria via Mieap-induced accumulation of…”
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