Search Results - "Kaminker, Joshua"

Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function by Jung, Min, Dourado, Michelle, Maksymetz, James, Jacobson, Amanda, Laufer, Benjamin I., Baca, Miriam, Foreman, Oded, Hackos, David H., Riol-Blanco, Lorena, Kaminker, Joshua S.

“…Sensory neurons of the dorsal root ganglion (DRG) are critical for maintaining tissue homeostasis by sensing and initiating responses to stimuli. While most…”
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Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models by Friedman, Brad A., Srinivasan, Karpagam, Ayalon, Gai, Meilandt, William J., Lin, Han, Huntley, Melanie A., Cao, Yi, Lee, Seung-Hye, Haddick, Patrick C.G., Ngu, Hai, Modrusan, Zora, Larson, Jessica L., Kaminker, Joshua S., van der Brug, Marcel P., Hansen, David V.

“…Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum of their possible activation states is not well understood. We…”
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Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching by Strasser, Geraldine A., Kaminker, Joshua S., Tessier-Lavigne, Marc

“…The development of the vertebrate vascular system is mediated by both genetic patterning of vessels and by angiogenic sprouting in response to hypoxia. Both of…”
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Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses by Srinivasan, Karpagam, Friedman, Brad A., Larson, Jessica L., Lauffer, Benjamin E., Goldstein, Leonard D., Appling, Laurie L., Borneo, Jovencio, Poon, Chungkee, Ho, Terence, Cai, Fang, Steiner, Pascal, van der Brug, Marcel P., Modrusan, Zora, Kaminker, Joshua S., Hansen, David V.

“…A common approach to understanding neurodegenerative disease is comparing gene expression in diseased versus healthy tissues. We illustrate that expression…”
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MicrobiomeExplorer: an R package for the analysis and visualization of microbial communities by Reeder, Janina, Huang, Mo, Kaminker, Joshua S, Paulson, Joseph N

“…Abstract Summary We developed the MicrobiomeExplorer R package to facilitate the analysis and visualization of microbial communities. The MicrobiomeExplorer R…”
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Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation by Chang, Michael C, Srinivasan, Karpagam, Friedman, Brad A, Suto, Eric, Modrusan, Zora, Lee, Wyne P, Kaminker, Joshua S, Hansen, David V, Sheng, Morgan

“…Loss-of-function mutations in cause frontotemporal dementia (FTD) with transactive response DNA-binding protein of 43 kD (TDP-43)-positive inclusions and…”
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DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury by Watkins, Trent A., Wang, Bei, Huntwork-Rodriguez, Sarah, Yang, Jing, Jiang, Zhiyu, Eastham-Anderson, Jeffrey, Modrusan, Zora, Kaminker, Joshua S., Tessier-Lavigne, Marc, Lewcock, Joseph W.

“…The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. Here we show…”
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Identification and functional analysis of endothelial tip cell–enriched genes by del Toro, Raquel, Prahst, Claudia, Mathivet, Thomas, Siegfried, Geraldine, Kaminker, Joshua S., Larrivee, Bruno, Breant, Christiane, Duarte, Antonio, Takakura, Nobuyuki, Fukamizu, Akiyoshi, Penninger, Josef, Eichmann, Anne

“…Sprouting of developing blood vessels is mediated by specialized motile endothelial cells localized at the tips of growing capillaries. Following behind the…”
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Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes by Kowanetz, Marcin, Wu, Xiumin, Lee, John, Tan, Martha, Hagenbeek, Thijs, Qu, Xueping, Yu, Lanlan, Ross, Jed, Korsisaari, Nina, Cao, Tim, Bou-Reslan, Hani, Kallop, Dara, Weimer, Robby, Ludlam, Mary J. C., Kaminker, Joshua S., Modrusan, Zora, van Bruggen, Nicholas, Peale, Franklin V., Carano, Richard, Meng, Y. Gloria, Ferrara, Napoleone

“…Priming of the organ-specific premetastatic sites is thought to be an important yet incompletely understood step during metastasis. In this study, we show that…”
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Single-Cell Transcriptomic Analysis Links Nonmyelinating Schwann Cells to Proinflammatory Response in the Lung by Heredia, Jose E, Jung, Min, Balestrini, Alessia, Doerr, Jonas, Paler-Martinez, Andres, Mozzarelli, Alessandro, Riol-Blanco, Lorena, Kaminker, Joshua S, Ding, Ning

“…The lung is a barrier tissue with constant exposure to the inhaled environment. Therefore, innate immunity against particulates and pathogens is of critical…”
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A resource for cell line authentication, annotation and quality control by Yu, Mamie, Selvaraj, Suresh K., Liang-Chu, May M. Y., Aghajani, Sahar, Busse, Matthew, Yuan, Jean, Lee, Genee, Peale, Franklin, Klijn, Christiaan, Bourgon, Richard, Kaminker, Joshua S., Neve, Richard M.

“…Cell line misidentification, contamination and poor annotation affect scientific reproducibility. Here we outline simple measures to detect or avoid…”
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Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability by Lauffer, Benjamin E.L., Mintzer, Robert, Fong, Rina, Mukund, Susmith, Tam, Christine, Zilberleyb, Inna, Flicke, Birgit, Ritscher, Allegra, Fedorowicz, Grazyna, Vallero, Roxanne, Ortwine, Daniel F., Gunzner, Janet, Modrusan, Zora, Neumann, Lars, Koth, Christopher M., Lupardus, Patrick J., Kaminker, Joshua S., Heise, Christopher E., Steiner, Pascal

“…Histone deacetylases (HDACs) are critical in the control of gene expression, and dysregulation of their activity has been implicated in a broad range of…”
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Disease-associated oligodendrocyte responses across neurodegenerative diseases by Pandey, Shristi, Shen, Kimberle, Lee, Seung-Hye, Shen, Yun-An A., Wang, Yuanyuan, Otero-García, Marcos, Kotova, Natalya, Vito, Stephen T., Laufer, Benjamin I., Newton, Dwight F., Rezzonico, Mitchell G., Hanson, Jesse E., Kaminker, Joshua S., Bohlen, Christopher J., Yuen, Tracy J., Friedman, Brad A.

“…Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative diseases, so understanding oligodendrocyte activation states would…”
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Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids by Deng, Lunbin, Dourado, Michelle, Reese, Rebecca M., Huang, Kevin, Shields, Shannon D., Stark, Kimberly L., Maksymetz, James, Lin, Han, Kaminker, Joshua S., Jung, Min, Foreman, Oded, Tao, Janet, Ngu, Hai, Joseph, Victory, Roose-Girma, Meron, Tam, Lucinda, Lardell, Susanne, Orrhult, Linnea Strid, Karila, Paul, Allard, Julien, Hackos, David H.

“…Loss-of-function mutations in Nav1.7, a voltage-gated sodium channel, cause congenital insensitivity to pain (CIP) in humans, demonstrating that Nav1.7 is…”
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Complex regulation of ADAR-mediated RNA-editing across tissues by Huntley, Melanie A, Lou, Melanie, Goldstein, Leonard D, Lawrence, Michael, Dijkgraaf, Gerrit J P, Kaminker, Joshua S, Gentleman, Robert

“…RNA-editing is a tightly regulated, and essential cellular process for a properly functioning brain. Dysfunction of A-to-I RNA editing can have catastrophic…”
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Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for histone deacetylase 4 by Chen, Yelin, Wang, Yuanyuan, Modrusan, Zora, Sheng, Morgan, Kaminker, Joshua S

“…Neuronal gene expression is modulated by activity via calcium-permeable receptors such as NMDA receptors (NMDARs). While gene expression changes downstream of…”
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Genomic Landscapes of Human Breast and Colorectal Cancers by Wood, Laura D, Parsons, D. Williams, Jones, Siân, Lin, Jimmy, Sjöblom, Tobias, Leary, Rebecca J, Shen, Dong, Boca, Simina M, Barber, Thomas, Ptak, Janine, Silliman, Natalie, Szabo, Steve, Dezso, Zoltan, Ustyanksky, Vadim, Nikolskaya, Tatiana, Nikolsky, Yuri, Karchin, Rachel, Wilson, Paul A, Kaminker, Joshua S, Zhang, Zemin, Croshaw, Randal, Willis, Joseph, Dawson, Dawn, Shipitsin, Michail, Willson, James K.V, Sukumar, Saraswati, Polyak, Kornelia, Park, Ben Ho, Pethiyagoda, Charit L, Pant, P.V. Krishna, Ballinger, Dennis G, Sparks, Andrew B, Hartigan, James, Smith, Douglas R, Suh, Erick, Papadopoulos, Nickolas, Buckhaults, Phillip, Markowitz, Sanford D, Parmigiani, Giovanni, Kinzler, Kenneth W, Velculescu, Victor E, Vogelstein, Bert

“…Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during…”
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Death Receptors DR6 and TROY Regulate Brain Vascular Development by Tam, Stephen J., Richmond, David L., Kaminker, Joshua S., Modrusan, Zora, Martin-McNulty, Baby, Cao, Tim C., Weimer, Robby M., Carano, Richard A.D., van Bruggen, Nick, Watts, Ryan J.

“…Signaling events that regulate central nervous system (CNS) angiogenesis and blood-brain barrier (BBB) formation are only beginning to be elucidated. By…”
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Single-molecule nanopore sequencing reveals extreme target copy number heterogeneity in arylomycin-resistant mutants by Girgis, Hany S., DuPai, Cory D., Lund, Jessica, Reeder, Janina, Guillory, Joseph, Durinck, Steffen, Liang, Yuxin, Kaminker, Joshua, Smith, Peter A., Skippington, Elizabeth

“…Tandem gene amplification is a frequent and dynamic source of antibiotic resistance in bacteria. Ongoing expansions and contractions of repeat arrays during…”
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Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy by Khan, Zia, Jung, Min, Crow, Megan, Mohindra, Rajat, Maiya, Vidya, Kaminker, Joshua S, Hackos, David H, Chandler, G Scott, McCarthy, Mark I, Bhangale, Tushar

“…Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with…”
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