Fecal metabolite of a gnotobiotic mouse transplanted with gut microbiota from a patient with Alzheimer's disease

Fecal metabolite of a gnotobiotic mouse transplanted with gut microbiota from a patient with Alzheimer's disease

Studies of Alzheimer's disease are based on model mice that have been altered by transgenesis and other techniques to elicit pathogenesis. However, changes in the gut microbiota were recently suggested to diminish cognitive function in patients, as well as in model mice. Accordingly, we have cr...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry Vol. 83; no. 11; pp. 2144 - 2152
Main Authors: Fujii, Yusuke, Nguyen, Thuy Tien Thi, Fujimura, Yuta, Kameya, Naotaka, Nakamura, Shoji, Arakawa, Kensuke, Morita, Hidetoshi
Format: Journal Article
Language:English
Published: England Taylor & Francis 02-11-2019
Oxford University Press
Subjects:
16S rRNA gene sequencing
Alzheimer Disease - microbiology
Alzheimer's disease
Animals
behavior
Behavior, Animal
Disease Models, Animal
Feces - chemistry
Feces - microbiology
Gastrointestinal Microbiome
Germ-Free Life
gut microbiota
Humans
Male
metabolome
Metabolomics
Mice
Time Factors
16S rRNA gene sequencing
Alzheimer’s disease
behavior
gut microbiota
metabolome
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Summary:Studies of Alzheimer's disease are based on model mice that have been altered by transgenesis and other techniques to elicit pathogenesis. However, changes in the gut microbiota were recently suggested to diminish cognitive function in patients, as well as in model mice. Accordingly, we have created model mice of the human gut microbiota by transplanting germ-free C57BL/6N mice with fecal samples from a healthy volunteer and from an affected patient. These humanized mice were stably colonized and reproduced the bacterial diversity in donors. Remarkably, performance on Object Location Test and Object Recognition Test was significantly reduced in the latter than in the former at 55 weeks of age, suggesting that gut microbiota transplanted from an affected patient affects mouse behavior. In addition, metabolites related to the nervous system, including γ-aminobutyrate, taurine, and valine, were significantly less abundant in the feces of mice transplanted with microbiota from the affected patient. Transplantation of fecal microbiota from patients with Alzheimer's disease alters fecal metabolome and behavior in recipient mice.
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ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2019.1644149