Search Results - "Kamerzell, Tim J"

Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development by Kamerzell, Tim J., Esfandiary, Reza, Joshi, Sangeeta B., Middaugh, C. Russell, Volkin, David B.

“…The purpose of this review is to demonstrate the critical importance of understanding protein–excipient interactions as a key step in the rational design of…”
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Coarse-Grained Modeling of the Self-Association of Therapeutic Monoclonal Antibodies by Chaudhri, Anuj, Zarraga, Isidro E, Kamerzell, Tim J, Brandt, J. Paul, Patapoff, Thomas W, Shire, Steven J, Voth, Gregory A

“…Coarse-grained computational models of two therapeutic monoclonal antibodies are constructed to understand the effect of domain-level charge–charge…”
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The complex inter-relationships between protein flexibility and stability by Kamerzell, Tim J, Middaugh, C Russell

“…The ability to successfully formulate and manufacture therapeutic protein dosage forms requires a thorough understanding of their physico-chemical properties…”
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The relative rate of immunoglobulin gamma 1 fragmentation by Kamerzell, Tim J, Li, Megan, Arora, Shaily, Ji, Junyan A, Wang, Y John

“…The physicochemical stability of protein therapeutics is of significant pharmaceutical interest. Immunoglobulin gamma (IgG) hinge region fragmentation has…”
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Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization by Connolly, Brian, Patapoff, Thomas W., Wang, Y. John, Moore, Jamie M., Kamerzell, Tim J.

“…Investigating the phase behavior of sugars in ice and lyophilized solids is of significant interest in the pharmaceutical industry. In this study, Raman and…”
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Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability by Ramsey, Joshua D, Gill, Michelle L, Kamerzell, Tim J, Price, E Shane, Joshi, Sangeeta B, Bishop, Steven M, Oliver, Cynthia N, Middaugh, C Russell

“…Understanding the relationship between protein dynamics and stability is of paramount importance to the fields of biology and pharmaceutics. Clarifying this…”
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Conformational Flexibility, Hydration and State Parameter Fluctuations of Fibroblast Growth Factor-10:  Effects of Ligand Binding by Kamerzell, Tim J, Unruh, Jay R, Johnson, Carey K, Middaugh, C. Russell

“…Differential effects of ligand binding on local and global fibroblast growth factor-10 (FGF-10) flexibility and stability have been investigated utilizing a…”
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The structural basis of histone modifying enzyme specificity and promiscuity: Implications for metabolic regulation and drug design by Kamerzell, Tim J, Mikell, Brittney, Chen, Lei, Elias, Harold, Dawn, Buddhadeb, MacRae, Calum, Middaugh, C Russell

“…Histone modifying enzymes regulate chromatin architecture through covalent modifications and ultimately control multiple aspects of cellular function…”
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Polar solvents decrease the viscosity of high concentration IgG1 solutions through hydrophobic solvation and interaction: formulation and biocompatibility considerations by Kamerzell, Tim J, Pace, Amanda L, Li, Megan, Danilenko, Dimitry M, McDowell, Michelle, Gokarn, Yatin R, Wang, Y John

“…Low-volume protein dosage forms for subcutaneous injection pose unique challenges to the pharmaceutical scientist. Indeed, high protein concentrations are…”
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Immunoglobulin Dynamics, Conformational Fluctuations, and Nonlinear Elasticity and Their Effects on Stability by Kamerzell, Tim J, Ramsey, Joshua D, Middaugh, C. Russell

“…The relationships between protein dynamics, function, and stability are incompletely understood. Two external perturbations (temperature and pH) were used to…”
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Increasing IgG Concentration Modulates the Conformational Heterogeneity and Bonding Network that Influence Solution Properties by Kamerzell, Tim J, Kanai, Sonoko, Liu, Jun, Shire, Steven J, Wang, Y. John

“…Multiple molecular driving forces mediate protein stability, association, and recognition in concentrated solutions. Here we investigate the interactions that…”
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Two-Dimensional Correlation Spectroscopy Reveals Coupled Immunoglobulin Regions of Differential Flexibility that Influence Stability by Kamerzell, Tim J, Middaugh, C. Russell

“…Despite the well-accepted importance of protein flexibility and dynamics in molecular recognition and conformational stability, our understanding of these…”
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Thermodynamic and structural characterization of an antibody gel by Esue, Osigwe, Xie, Anna X., Kamerzell, Tim J., Patapoff, Thomas W.

“…Although extensively studied, protein-protein interactions remain highly elusive and are of increasing interest in drug development. We show the assembly of a…”
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Characteristics of rhVEGF Release from Topical Hydrogel Formulations by Ji, Junyan A., Liu, Jun, Shire, Steven J., Kamerzell, Tim J., Hong, Sung, Billeci, Karen, Shen, Ye, Wang, Y. John

“…Purpose To study recombinant human vascular endothelial growth factor (rhVEGF), the release characteristics from topical gel formulations, and its interaction…”
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The interaction of heparin/polyanions with bovine, porcine, and human growth hormone by Joshi, Sangeeta B, Kamerzell, Tim J, McNown, Chris, Middaugh, C Russell

“…The interaction of polyanions with proteins is of potential pharmaceutical and cellular significance. A partial thermodynamic description of the interaction of…”
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Parathyroid hormone is a heparin/polyanion binding protein: Binding energetics and structure modification by Kamerzell, Tim J., Joshi, Sangeeta B., McClean, Donald, Peplinskie, Lori, Toney, Karen, Papac, Damon, Li, Meili, Middaugh, C. Russell

“…The interaction of four representative polyanions with parathyroid hormone (PTH) residues 1–84 has been investigated utilizing a variety of spectroscopic and…”
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Spectroscopy and Photophysics of Indoline and Indoline-2-Carboxylic Acid by Allen, Michael W, Unruh, Jay R, Slaughter, Brian D, Pyszczynski, Sarah J, Hellwig, Thaddaus R, Kamerzell, Tim J, Johnson, Carey K

“…This paper presents a detailed description of the fluorescence and photophysical behavior of indoline and indoline-2-carboxylic acid (I2CA). Indoline is an…”
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Protein―excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development: FORMULATING BIOMOLECULES: MECHANISTICS INSIGHTS IN MOLECULAR INTERACTIONS by KAMERZELL, Tim J, ESFANDIARY, Reza, JOSHI, Sangeeta B, RUSSELL MIDDAUGH, C, VOLKIN, David B

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Toward a better understanding of the relationships between protein flexibility and stability: Effects of temperature, pH and ligand binding by Kamerzell, Tim J

“…The ability to successfully formulate and manufacture therapeutic protein dosage forms requires a thorough understanding of their physico-chemical properties…”
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Toward a better understanding of the relationships between protein flexibility and stability: Effects of temperature,pH and ligand binding by Kamerzell, Tim J

“…The ability to successfully formulate and manufacture therapeutic protein dosage forms requires a thorough understanding of their physico-chemical properties…”
Get full text