Search Results - "Kamendulis, L M"

Role of the Kupffer Cell in Mediating Hepatic Toxicity and Carcinogenesis by Roberts, Ruth A., Ganey, Patricia E., Ju, Cynthia, Kamendulis, Lisa M., Rusyn, Ivan, Klaunig, James E.

“…Kupffer cells are resident macrophages of the liver and play an important role in its normal physiology and homeostasis as well as participating in the acute…”
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Epigenetic mechanisms of chemical carcinogenesis by Klaunig, J E, Kamendulis, L M, Xu, Y

“…Chemically induced cancer is a multi-step process involving damage to the genome initially followed by clonal expansion of the DNA damaged cell eventually…”
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Mode of action of butoxyethanol-induced mouse liver hemangiosarcomas and hepatocellular carcinomas by Klaunig, J.E., Kamendulis, L.M.

“…Chronic exposure to 2-butoxyethanol resulted in an increase in liver hemangiosarcomas and hepatic carcinomas in male mouse liver. No increase in liver…”
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Inhibition of cellular transformation by berry extracts by Xue, Hongwei, Aziz, Robeena M., Sun, Nanjun, Cassady, John M., Kamendulis, Lisa M., Xu, Yong, Stoner, Gary D., Klaunig, James E.

“…Recent studies have examined and demonstrated the potential cancer chemopreventive activity of freeze-dried berries including strawberries and black…”
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Induction of oxidative stress and oxidative damage in rat glial cells by acrylonitrile by Kamendulis, L.M., Jiang, J., Xu, Y., Klaunig, J.E.

“…Chronic treatment of rats with acrylonitrile (ACN) resulted in a dose-related increase in glial cell tumors (astrocytomas). While the exact mechanism(s) for…”
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Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases by Kamendulis, L M, Brzezinski, M R, Pindel, E V, Bosron, W F, Dean, R A

“…Concomitant i.v. use of cocaine and heroin ("speedballing") is prevalent among drug-abusing populations. Heroin is rapidly metabolized by sequential…”
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Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeys by PUGH, G. JR, ISENBERG, J. S, KAMENDULIS, L. M, ACKLEY, D. C, CLARE, L. J, BROWN, R, LINGTON, A. W, SMITH, J. H, KLAUNIG, J. E

“…The effects of the peroxisome proliferators di-isononyl phthalate (DINP) and di-2-ethylhexyl phthalate (DEHP) were evaluated in young adult male cynomolgus…”
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Acrylonitrile-induced morphological transformation in Syrian hamster embryo cells by Zhang, Haizhou, Kamendulis, Lisa M., Jiang, Jiazhong, Xu, Yong, Klaunig, James E.

“…Acrylonitrile (ACN) is a monomer used in the synthesis of rubber, fibers and plastics. Previous studies demonstrated that ACN induces brain neoplasms…”
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Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen by Ray, S D, Kamendulis, L M, Gurule, M W, Yorkin, R D, Corcoran, G B

“…Ca2+ accumulates in the nucleus and DNA undergoes enzymatic cleavage into internucleosome-length fragments before acetaminophen and dimethylnitrosamine produce…”
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Ca(++)-activated DNA fragmentation and dimethylnitrosamine-induced hepatic necrosis: effects of Ca(++)-endonuclease and poly(ADP-ribose) polymerase inhibitors in mice by Ray, S D, Sorge, C L, Kamendulis, L M, Corcoran, G B

“…Several hepatotoxic agents damage Ca++ regulation and produce toxic cell death in a manner consistent with a cause-and-effect relationship; however, vital…”
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Effects of Di-2-ethylhexyl phthalate (DEHP) on gap-junctional intercellular communication (GJIC), DNA synthesis, and peroxisomal beta oxidation (PBOX) in rat, mouse, and hamster liver by ISENBERG, J. S, KAMENDULIS, L. M, SMITH, J. H, ACKLEY, D. C, PUGH, G. JR, LINGTON, A. W, KLAUNIG, J. E

“…The present study evaluated the effect of di-2-ethylhexyl phthalate (DEHP) on gap-junctional intercellular communication (GJIC), peroxisomal beta-oxidation…”
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Morphological transformation by 8-hydroxy-2'-deoxyguanosine in Syrian hamster embryo (SHE) cells by HAIZHOU ZHANG, YONG XU, KAMENDULIS, L. M, KLAUNIG, J. E

“…8-Hydroxy-2'-deoxyguanosine (OH8dG) is one of the most prevalent oxidative DNA modifications found in eukaryotic cells. Previous studies have suggested an…”
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Morphological Transformation and Oxidative Stress Induced by Cyanide in Syrian Hamster Embryo (SHE) Cells by Kamendulis, Lisa M., Zhang, Haizhou, Wang, Yanhong, Klaunig, James E.

“…Cyanide is a well-established poison known for its rapid lethal action and toxicity. Although long-term mammalian studies examining the carcinogenic potential…”
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The effect of acrylonitrile on gap junctional intercellular communication in rat astrocytes by KAMENDULIS, L. M, JIANG, J, ZHANG, H, DEFEIJTER-RUPP, H, TROSKO, J. E, KLAUNIG, J. E

“…Rats chronically exposed to acrylonitrile (ACN) have shown a dose-dependent increase in the incidence of astrocytomas in the brain. The mechanism(s) by which…”
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Monograph: Reassessment of human cancer risk of aldrin/dieldrin by Stevenson, Donald E, Walborg, Earl F, Warner North, D, Sielken, Robert L, Ross, C.E, Wright, Alan S, Xu, Yong, Kamendulis, Lisa M, Klaunig, James E

“…In 1987, the US Environmental Protection Agency (EPA) classified aldrin and dieldrin as category B 2 carcinogens, i.e. probable human carcinogens, based…”
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DNA as a critical target in toxic cell death: enhancement of dimethylnitrosamine cytotoxicity by DNA repair inhibitors by Kamendulis, L M, Corcoran, G B

“…Our working hypothesis states that DNA damage is a critical step in toxic cell death. The DNA hypothesis was tested in cultured mouse hepatocytes by examining…”
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Acrylamide-induced cellular transformation by PARK, Joungjoa, KAMENDULIS, Lisa M, FRIEDMAN, Marvin A, KLAUNIG, James E

“…Acrylamide is a monomer of polyacrylamide, whose products are used in biochemistry, the manufacture of paper, water treatment, and as a soil stabilizer. While…”
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Menadione-induced DNA fragmentation without 8-oxo-2′-deoxyguanosine formation in isolated rat hepatocytes by Fischer-Nielsen, Anne, Corcoran, George B., Poulsen, Henrik E., Kamendulis, Lisa M., Loft, Steffen

“…Menadione (2-methyl-1,4-naphthoquinone) induces oxidative stress in cells causing perturbations in the cytoplasm as well as nicking of DNA. The mechanisms by…”
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Mechanisms of cancer chemoprevention in hepatic carcinogenesis : Modulation of focal lesion growth in mice by KLAUNIG, J. E, KAMENDULIS, L. M

“…Studies in our laboratory have concentrated on further understanding the mechanism by which chemicals induce cancer and the means to prevent or retard this…”
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Subchronic acrylamide treatment induces a tissue-specific increase in DNA synthesis in the rat by Lafferty, Jeffery S., Kamendulis, Lisa M., Kaster, JuLee, Jiang, Jiazhong, Klaunig, James E.

“…Chronic treatment with acrylamide results in increased incidence of adrenal (pheochromocytoma), testicular (mesotheliomas) and thyroid (adenoma) neoplasia in…”
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