Search Results - "Kamendi, Harriet W."

An integrative pharmacological approach to radio telemetry and blood sampling in pharmaceutical drug discovery and safety assessment by Litwin, Dennis C, Lengel, David J, Kamendi, Harriet W, Bialecki, Russell A

“…A successful integration of the automated blood sampling (ABS) and telemetry (ABST) system is described. The new ABST system facilitates concomitant collection…”
Get full text

Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity by Lamore, Sarah D, Kamendi, Harriet W, Scott, Clay W, Dragan, Yvonne P, Peters, Matthew F

“…Cardiovascular (CV) toxicity is a leading contributor to drug attrition. Implementing earlier testing has successfully reduced human Ether-à-go-go-Related…”
Get full text

5HT1A receptors inhibit glutamate inputs to cardiac vagal neurons post-hypoxia/hypercapnia by Dergacheva, Olga, Kamendi, Harriet W, Wang, Xin, Mendelowitz, David

“…Highlights ► 5HT1A receptors do not alter excitatory neurotransmission to cardiac vagal neurons (CVNs) under control conditions. ► During recovery from…”
Get full text

Multi-compartmental PK-PD modeling of baclofen by Kamendi, Harriet W., Bui, Khanh, Lengel, David J., Bialecki, Russell

Get full text

Combining radio telemetry and automated blood sampling: A novel approach for integrative pharmacology and toxicology studies by Kamendi, Harriet W., Brott, David A., Chen, Yafei, Litwin, Dennis C., Lengel, David J., Fonck, Carlos, Bui, Khanh H., Gorko, Mary Ann, Bialecki, Russell A.

“…A novel automated blood sampling and telemetry (ABST) system was developed to integrate pharmacokinetic (PK), pharmacodynamic (PD) and toxicology studies. The…”
Get full text

Reactive Oxygen Species Mediate Central Cardiorespiratory Network Responses to Acute Intermittent Hypoxia by Griffioen, Kathleen J. S, Kamendi, Harriet W, Gorini, Christopher J, Bouairi, Evguenia, Mendelowitz, David

“…Department of Pharmacology and Physiology, George Washington University, Washington, District of Columbia Submitted 12 September 2006; accepted in final form 1…”
Get full text

5HT1A Receptor Mediated Inhibition of Glutamatergic Neurotransmission to Cardiac Vagal Neurons Following Hypoxia and Hypercapnia by Mendelowitz, David, Kamendi, Harriet W

“…Abstract only Cardiac vagal neurons (CVNs) are excited by serotonergic and purinergic pathways recruited post hypoxia / hypercapnia (H/H). Surprisingly,…”
Get full text