Search Results - "Kamenšek, Urška"

Interleukins and interferons in mesenchymal stromal stem cell-based gene therapy of cancer by Švajger, Urban, Kamenšek, Urška

“…The tumor microenvironment is importantly shaped by various cytokines, where interleukins (ILs) and interferons (IFNs) shape the balance of immune activity…”
Get full text

Human amniotic membrane inhibits migration and invasion of muscle-invasive bladder cancer urothelial cells by downregulating the FAK/PI3K/Akt/mTOR signalling pathway by Janev, Aleksandar, Ramuta, Taja Železnik, Jerman, Urška Dragin, Obradović, Hristina, Kamenšek, Urška, Čemažar, Maja, Kreft, Mateja Erdani

“…Bladder cancer is the 10th most commonly diagnosed cancer with the highest lifetime treatment costs. The human amniotic membrane (hAM) is the innermost foetal…”
Get full text

How Cancer Cells Invade Bladder Epithelium and Form Tumors: The Mouse Bladder Tumor Model as a Model of Tumor Recurrence in Patients by Erman, Andreja, Kamenšek, Urška, Dragin Jerman, Urška, Pavlin, Mojca, Čemažar, Maja, Veranič, Peter, Romih, Rok

“…Non-muscle-invasive bladder cancer is the most common form of bladder cancer. The main problem in managing bladder tumors is the high recurrence after the…”
Get full text

Human Omental Mature Adipocytes used as Paclitaxel Reservoir for Cell‐Based Therapy in Ovarian Cancer by Andele, Pacome K., Palazzolo, Stefano, Corona, Giuseppe, Caligiuri, Isabella, Kamensek, Urska, Cemazar, Maja, Canzonieri, Vincenzo, Rizzolio, Flavio

“…Primary human omental adipocytes and ovarian cancer(OC) cells establish a bidirectional communication in which tumor driven lipolysis is induced in adipocytes…”
Get full text

Polymer-Mediated Delivery of siRNAs to Hepatocellular Carcinoma: Variables Affecting Specificity and Effectiveness by Farra, Rossella, Musiani, Francesco, Perrone, Francesca, Čemažar, Maja, Kamenšek, Urška, Tonon, Federica, Abrami, Michela, Ručigaj, Aleš, Grassi, Mario, Pozzato, Gabriele, Bonazza, Deborah, Zanconati, Fabrizio, Forte, Giancarlo, El Boustani, Maguie, Scarabel, Lucia, Garziera, Marica, Russo Spena, Concetta, De Stefano, Lucia, Salis, Barbara, Toffoli, Giuseppe, Rizzolio, Flavio, Grassi, Gabriele, Dapas, Barbara

“…Despite the advances in anticancer therapies, their effectiveness for many human tumors is still far from being optimal. Significant improvements in treatment…”
Get full text

Adipose tissue stem cell-derived hepatic progenies as an in vitro model for genotoxicity testing by Tomc, Jana, Kološa, Katja, Žegura, Bojana, Kamenšek, Urška, Breznik, Barbara, Turnšek, Tamara Lah, Filipič, Metka

“…The problem of the currently used routine genotoxicity tests is relatively low predictivity of in vitro tests for in vivo genotoxicity and carcinogenicity. An…”
Get full text

Evaluation of shRNA-mediated gene silencing by electroporation in LPB fibrosarcoma cells by Mesojednik, Suzana, Kamenšek, Urška, Čemažar, Maja

“…Evaluation of shRNA-mediated gene silencing by electroporation in LPB fibrosarcoma cells [Background.] Silencing oncogenes or other genes that contribute to…”
Get full text

Tumor Radiosensitization by Gene Electrotransfer-Mediated Double Targeting of Tumor Vasculature by Savarin, Monika, Znidar, Katarina, Sersa, Gregor, Komel, Tilen, Cemazar, Maja, Kamensek, Urska

“…Targeting the tumor vasculature through specific endothelial cell markers involved in different signaling pathways represents a promising tool for tumor…”
Get full text

Evaluation of a Novel Plasmid for Simultaneous Gene Electrotransfer-Mediated Silencing of CD105 and CD146 in Combination with Irradiation by Savarin, Monika, Kamensek, Urska, Znidar, Katarina, Todorovic, Vesna, Sersa, Gregor, Cemazar, Maja

“…Targeting tumor vasculature through specific endothelial cell markers represents a promising approach for cancer treatment. Here our aim was to construct an…”
Get full text

Gene Immunotherapy of Colon Carcinoma with IL-2 and IL-12 Using Gene Electrotransfer by Komel, Tilen, Omerzel, Masa, Kamensek, Urska, Znidar, Katarina, Lampreht Tratar, Ursa, Kranjc Brezar, Simona, Dolinar, Klemen, Pirkmajer, Sergej, Sersa, Gregor, Cemazar, Maja

“…Gene immunotherapy has become an important approach in the treatment of cancer. One example is the introduction of genes encoding immunostimulatory cytokines,…”
Get full text

Non-clinical evaluation of pmIL12 gene therapy for approval of the phase I clinical study by Markelc, Bostjan, Jesenko, Tanja, Kranjc Brezar, Simona, Omerzel, Masa, Lampreht Tratar, Ursa, Rencelj, Andrej, Matkovic, Urska, Znidar, Katarina, Kos, Spela, Levpuscek, Kristina, Pisljar, Ziva, Kesar, Ursa, Komel, Tilen, Bozic, Tim, Tuljak, Aneja, Hudej, Rosana, Peterka, Matjaz, Kamensek, Urska, Cör, Andrej, Gasljevic, Gorana, Nemec Svete, Alenka, Tozon, Natasa, Sersa, Gregor, Cemazar, Maja

“…Immunotherapeutic drugs are promising medicines for cancer treatment. A potential candidate for immunotherapy is interleukin-12 (IL-12), a cytokine well known…”
Get full text

Tumor cell-based vaccine contributes to local tumor irradiation by eliciting a tumor model-dependent systemic immune response by Remic, Tinkara, Sersa, Gregor, Levpuscek, Kristina, Lampreht Tratar, Ursa, Ursic Valentinuzzi, Katja, Cör, Andrej, Kamensek, Urska

“…Multimodal treatment approaches, such as radio-immunotherapy, necessitate regimen optimization and the investigation of the interactions of different…”
Get full text

Gene Electrotransfer of Plasmid-Encoding IL-12 Recruits the M1 Macrophages and Antigen-Presenting Cells Inducing the Eradication of Aggressive B16F10 Murine Melanoma by Signori, Emanuela, Fazio, Vito Michele, Kamensek, Urska, Cemazar, Maja, Loiacono, Luisa, Lampreht Tratar, Ursa, Sersa, Gregor

“…Cancer immunotherapy is currently one of the leading approaches in cancer treatment. Gene electrotransfer of plasmids encoding interleukin 12 (IL-12) into the…”
Get full text

Development of Tumor Cell-Based Vaccine with IL-12 Gene Electrotransfer as Adjuvant by Remic, Tinkara, Sersa, Gregor, Ursic, Katja, Cemazar, Maja, Kamensek, Urska

“…Tumor cell-based vaccines use tumor cells as a source of tumor-associated antigens. In our study, we aimed to develop and test a tumor vaccine composed of…”
Get full text

Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response by Savarin, Monika, Kamensek, Urska, Cemazar, Maja, Heller, Richard, Sersa, Gregor

“…Tumor irradiation combined with adjuvant treatments, either vascular targeted or immunomodulatory, is under intense investigation. Gene electrotransfer of…”
Get full text

Maintenance and gene electrotransfer efficiency of antibiotic resistance gene-free plasmids encoding mouse, canine and human interleukin-12 orthologues by Kamensek, Urska, Rencelj, Andrej, Jesenko, Tanja, Remic, Tinkara, Sersa, Gregor, Cemazar, Maja

“…Interleukin 12 (IL-12) is a cytokine used as a therapeutic molecule in cancer immunotherapy. Gene electrotransfer mediated delivery of IL-12 gene has reached…”
Get full text

Non-Clinical In Vitro Evaluation of Antibiotic Resistance Gene-Free Plasmids Encoding Human or Murine IL-12 Intended for First-in-Human Clinical Study by Kos, Spela, Bosnjak, Masa, Jesenko, Tanja, Markelc, Bostjan, Kamensek, Urska, Znidar, Katarina, Matkovic, Urska, Rencelj, Andrej, Sersa, Gregor, Hudej, Rosana, Tuljak, Aneja, Peterka, Matjaz, Cemazar, Maja

“…Interleukin 12 (IL-12) is a key cytokine that mediates antitumor activity of immune cells. To fulfill its clinical potential, the development is focused on…”
Get full text

5-Azacytidine Downregulates the Proliferation and Migration of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Targeting miR-139-5p/ROCK2 Pathway by Tonon, Federica, Cemazar, Maja, Kamensek, Urska, Zennaro, Cristina, Pozzato, Gabriele, Caserta, Sergio, Ascione, Flora, Grassi, Mario, Guido, Stefano, Ferrari, Cinzia, Cansolino, Laura, Trotta, Francesco, Kuzmanov, Biljana Grcar, Forte, Giancarlo, Martino, Fabiana, Perrone, Francesca, Bomben, Riccardo, Gattei, Valter, Elvassore, Nicola, Murano, Erminio, Truong, Nhung Hai, Olson, Michael, Farra, Rossella, Grassi, Gabriele, Dapas, Barbara

“…For hepatocellular carcinoma (HCC), effective therapeutic approaches are lacking. As aberrant gene methylation is a major contributor to HCC development,…”
Get full text

What We Learned about the Feasibility of Gene Electrotransfer for Vaccination on a Model of COVID-19 Vaccine by Kamensek, Urska, Cemazar, Maja, Kranjc Brezar, Simona, Jesenko, Tanja, Kos, Spela, Znidar, Katarina, Markelc, Bostjan, Modic, Ziva, Komel, Tilen, Gorse, Tim, Rebersek, Eva, Jakopic, Helena, Sersa, Gregor

“…DNA vaccination is one of the emerging approaches for a wide range of applications, including prophylactic vaccination against infectious diseases and…”
Get full text

In Vitro and In Vivo Evaluation of the Effects of Drug 2c and Derivatives on Ovarian Cancer Cells by Maddaloni, Marianna, Farra, Rossella, Dapas, Barbara, Felluga, Fulvia, Benedetti, Fabio, Berti, Federico, Drioli, Sara, Vidali, Mattia, Cemazar, Maja, Kamensek, Urska, Brancolini, Claudio, Murano, Erminio, Maremonti, Francesca, Grassi, Mario, Biasin, Alice, Rizzolio, Flavio, Cavarzerani, Enrico, Scaggiante, Bruna, Bulla, Roberta, Balduit, Andrea, Ricci, Giuseppe, Zito, Gabriella, Romano, Federico, Bonin, Serena, Azzalini, Eros, Baj, Gabriele, Tierno, Domenico, Grassi, Gabriele

“…The identification of novel therapeutic strategies for ovarian cancer (OC), the most lethal gynecological neoplasm, is of utmost urgency. Here, we have tested…”
Get full text