Search Results - "Kamen, Douglas E."

Low pKa of Lys promotes glycation at one complementarity-determining region of a bispecific antibody by Xu, Xiaobin, O'Callaghan, Jessica Ann, Guarnero, Zachary, Qiu, Haibo, Li, Ning, Potocky, Terra, Kamen, Douglas E., Graham, Kenneth S., Shameem, Mohammed, Yang, Teng-Chieh

“…Protein glycation is a common, normally innocuous, post-translational modification in therapeutic monoclonal antibodies. However, when glycation occurs on…”
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Low pK a of Lys promotes glycation at one complementarity-determining region of a bispecific antibody by Xu, Xiaobin, O'Callaghan, Jessica Ann, Guarnero, Zachary, Qiu, Haibo, Li, Ning, Potocky, Terra, Kamen, Douglas E, Graham, Kenneth S, Shameem, Mohammed, Yang, Teng-Chieh

“…Protein glycation is a common, normally innocuous, post-translational modification in therapeutic monoclonal antibodies. However, when glycation occurs on…”
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An Intercompany Perspective on Compatibility and In-use Stability Studies to Enable Administration Of Biopharmaceutical Drug Products by Kamen, Douglas E, Crotts, George, Narasimhan, Chakravarthy, Hu, Qingyan, Bhargava, Adithi C, Muthurania, Kevin, Burton, Lori, Gbormittah, Francisca O, Mathews, Ligi, Mills, Brittney, Hodge, Tamara, Saluja, Sonal, Singh, Shubhadra N, Tabish, Tanvir, Wu, Yongmei, Stokes, Elaine S E

“…In-use stability and compatibility studies are often used in biotherapeutic development to assess stability and compatibility of biologic drugs with diluents…”
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An Intercompany Perspective on Practical Experiences of Predicting, Optimizing and Analyzing High Concentration Biologic Therapeutic Formulations by Desai, Preeti G, Garidel, Patrick, Gbormittah, Francisca O, Kamen, Douglas E, Mills, Brittney J, Narasimhan, Chakravarthy N, Singh, Shubhadra, Stokes, Elaine S E, Walsh, Erika R

“…Developing high-dose biologic drugs for subcutaneous injection often requires high-concentration formulations and optimizing viscosity, solubility, and…”
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Structural Basis for the Physiological Temperature Dependence of the Association of VP16 with the Cytoplasmic Tail of Herpes Simplex Virus Glycoprotein H by KAMEN, Douglas E, GROSS, Sarah T, GIRVIN, Mark E, WILSON, Duncan W

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Multiple Alignment of Membrane Proteins for Measuring Residual Dipolar Couplings Using Lanthanide Ions Bound to a Small Metal Chelator by Kamen, Douglas E, Cahill, Sean M, Girvin, Mark E

“…NMR structure determination of helical integral membrane proteins is one of the most challenging undertakings in modern structural biology. The solubilizing…”
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GFT projection NMR based resonance assignment of membrane proteins: application to subunit c of E. coli F₁F₀ ATP synthase in LPPG micelles by Zhang, Qi, Atreya, Hanudatta S, Kamen, Douglas E, Girvin, Mark E, Szyperski, Thomas

“…G-matrix FT projection NMR spectroscopy was employed for resonance assignment of the 79-residue subunit c of the Escherichia coli F₁F₀ ATP synthase embedded in…”
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Folding Kinetics of the Protein Pectate Lyase C Reveal Fast-Forming Intermediates and Slow Proline Isomerization by Kamen, Douglas E, Woody, Robert W

“…Pectate lyase C (pelC) is a member of the class of proteins that possess a parallel β-helix folding motif. A study of the kinetic folding mechanism is…”
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Identification of Proline Residues Responsible for the Slow Folding Kinetics in Pectate Lyase C by Mutagenesis by Kamen, Douglas E, Woody, Robert W

“…The folding mechanism of pectate lyase C (pelC) involves two slow phases that have been attributed to proline isomerization. To have a more detailed and…”
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The Stability, Structural Organization, and Denaturation of Pectate Lyase C, a Parallel β-Helix Protein by Kamen, Douglas E, Griko, Yuri, Woody, Robert W

“…Pectate lyase C (pelC) was the first protein in which the parallel β-helix structure was recognized. The unique features of parallel β-helix-containing…”
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GFT projection NMR based resonance assignment of membrane proteins: application to subunit C of E. coli F(1)F (0) ATP synthase in LPPG micelles by Zhang, Qi, Atreya, Hanudatta S, Kamen, Douglas E, Girvin, Mark E, Szyperski, Thomas

“…G-matrix FT projection NMR spectroscopy was employed for resonance assignment of the 79-residue subunit c of the Escherichia coli F(1)F(0) ATP synthase…”
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GFT projection NMR based resonance assignment of membrane proteins: application to subunit c of E. coli F sub(1)F sub(0) ATP synthase in LPPG micelles by Zhang, Qi, Atreya, Hanudatta S, Kamen, Douglas E, Girvin, Mark E, Szyperski, Thomas

“…G-matrix FT projection NMR spectroscopy was employed for resonance assignment of the 79-residue subunit c of the Escherichia coli F sub(1)F sub(0) ATP synthase…”
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A partially folded intermediate conformation is induced in pectate lyase C by the addition of 8‐anilino‐1‐naphthalenesulfonate (ANS) by Kamen, Douglas E., Woody, Robert W.

“…Addition of 8‐anilino‐1‐naphthalenesulfonate (ANS) to acid‐denatured pectate lyase C (pelC) leads to a large increase in the fluorescence quantum yield near…”
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Energetic and kinetic folding mechanisms of the parallel β-helix protein pectate lyase C by Kamen, Douglas E

“…Pectate lyase C (pelC) was the first protein in which the parallel β-helix structure was recognized. The unique features of parallel β-helix-containing…”
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