The Prognostic Role of Fibulin-2 and Ki-67 Index in Patients with Meningioma: A Study among Minangkabau Ethnicity

To analyze the association between fibulin-2 and Ki-67 index with histopathological grade and other clinicopathological factors in patients with meningioma among the Minangkabau ethnic group. This cross-sectional observational study uses 50 specimens comprising 25 low-risk meningioma cases and 25 hi...

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Bibliographic Details
Published in:	Asian Pacific journal of cancer prevention : APJCP Vol. 25; no. 8; pp. 2735 - 2742
Main Authors:	Setiawati, Yessy, Alimuddin, Tofrizal, Mulyani, Henny, Kamelia, Muthia
Format:	Journal Article
Language:	English
Published:	Thailand West Asia Organization for Cancer Prevention 01-08-2024
Subjects:	Adult Aged Biomarkers, Tumor - metabolism Calcium-Binding Proteins - metabolism Cross-Sectional Studies Ethnicity Extracellular Matrix Proteins Female Follow-Up Studies Humans Indonesia - epidemiology Ki-67 Antigen - metabolism Male Meningeal Neoplasms - metabolism Meningeal Neoplasms - pathology Meningioma - metabolism Meningioma - pathology Middle Aged Neoplasm Grading Prognosis Indonesia meningioma Ki-67 Protein expression histopathological grade Fibulin-2
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Summary:	To analyze the association between fibulin-2 and Ki-67 index with histopathological grade and other clinicopathological factors in patients with meningioma among the Minangkabau ethnic group. This cross-sectional observational study uses 50 specimens comprising 25 low-risk meningioma cases and 25 high-risk meningioma cases obtained at three anatomical pathology laboratories in Padang, West Sumatra, Indonesia, between 2019 and 2022. All samples were stained using an immunohistochemistry procedure with Ki-67 and fibulin-2. The chi-square test was used to assess IBM SPSS statistics version 26 for Windows was used to assess the association of Ki-67 and fibulin-2 with the histopathological grade. The p-value of <0.05 was considered significant. We found a significant association between Ki-67 (p = 0.013) or fibulin-2 (p = 0.001) expression with histopathological grade of meningioma. High histopathological grade has high expression of Ki-67 and fibulin-2, with Odds ratio (OR) of 13.500 (1.556-117.137) and 10.028 (2,738-36,722), respectively. Fibulin-2 expression was also associated with the age of patients (p = 0.020). The low age group (<50) has high expression of fibulin-2 (OR 0.196 (0.056-0.691). Conclusion: Ki-67 and fibulin-2 were associated with the histopathological grade of meningioma, while fibulin-2 is also associated with age in the Minangkabau ethnic group.
ISSN:	1513-7368 2476-762X
DOI:	10.31557/APJCP.2024.25.8.2735