Search Results - "Kamelia, Lenny"

In vitro metabolism of naphthalene and its alkylated congeners by human and rat liver microsomes via alkyl side chain or aromatic oxidation by Wang, Danlei, Bruyneel, Ben, Kamelia, Lenny, Wesseling, Sebastiaan, Rietjens, Ivonne M.C.M., Boogaard, Peter J.

“…Mineral oils are widely applied in food production and processing and may contain polycyclic aromatic hydrocarbons (PAHs). The PAHs that may be present in…”
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Predicting the in vivo developmental toxicity of benzo[a]pyrene (BaP) in rats by an in vitro–in silico approach by Wang, Danlei, Rietdijk, Maartje H., Kamelia, Lenny, Boogaard, Peter J., Rietjens, Ivonne M. C. M.

“…Developmental toxicity testing is an animal-intensive endpoints in toxicity testing and calls for animal-free alternatives. Previous studies showed the…”
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The Role of Endocrine and Dioxin-Like Activity of Extracts of Petroleum Substances in Developmental Toxicity as Detected in a Panel of CALUX Reporter Gene Assays by Kamelia, Lenny, Louisse, Jochem, de Haan, Laura, Maslowska-Gornicz, Anna, Ketelslegers, Hans B, Brouwer, Abraham, Rietjens, Ivonne M C M, Boogaard, Peter J

“…Abstract Recent evidence suggests that the interaction of polycyclic aromatic hydrocarbons (PAHs), present in some petroleum substances (PS), with particular…”
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Prenatal developmental toxicity testing of petroleum substances using the zebrafish embryotoxicity test_suppl by Kamelia, Lenny

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Comparison of PAC and MOAH for understanding the carcinogenic and developmental toxicity potential of mineral oils by Carrillo, Juan-Carlos, Kamelia, Lenny, Romanuka, Julija, Kral, Olaf, Isola, Allison, Niemelä, Helena, Steneholm, Anna

“…The carcinogenicity and developmental toxicity of unrefined mineral oil is related to its 3–7 ring polycyclic aromatic compounds (PAC) content. Therefore,…”
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Interindividual Differences in Human Intestinal Microbial Conversion of (−)-Epicatechin to Bioactive Phenolic Compounds by Liu, Chen, Vervoort, Jacques, Beekmann, Karsten, Baccaro, Marta, Kamelia, Lenny, Wesseling, Sebas, Rietjens, Ivonne M. C. M

“…To quantify interindividual differences in the human intestinal microbial metabolism of (−)-epicatechin (EC), in vitro anaerobic incubations with fecal inocula…”
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Developmental toxicity testing of unsubstituted and methylated 4- and 5-ring polycyclic aromatic hydrocarbons using the zebrafish embryotoxicity test by Fang, Jing, Dong, Shutong, Boogaard, Peter J., Rietjens, Ivonne M.C.M., Kamelia, Lenny

“…The present study evaluates the in vitro developmental toxicity of 4- and 5-ring polycyclic aromatic hydrocarbons (PAHs) including benz[a]anthracene (BaA) and…”
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Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Caucasian and Chinese Population by Zhao, Shensheng, Kamelia, Lenny, Boonpawa, Rungnapa, Wesseling, Sebastiaan, Spenkelink, Bert, Rietjens, Ivonne M C M

“…Organophosphates have a long history of use as insecticides over the world. The aim of the present study was to investigate the interethnic differences in…”
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Evaluating the in vitro developmental toxicity potency of a series of petroleum substance extracts using new approach methodologies (NAMs) by Fang, Jing, Rietjens, Ivonne M. C. M., Carrillo, Juan-Carlos, Boogaard, Peter J., Kamelia, Lenny

“…The present study evaluates the in vitro developmental toxicity and the possible underlying mode of action of DMSO extracts of a series of highly complex…”
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The role of metabolism in the prenatal developmental toxicity (PDT) of polycyclic aromatic hydrocarbons (PAHs) in petroleum substances by Kamelia, Lenny, Louisse, Jochem, Rietjens, Ivonne M.C.M., Boogaard, Peter J.

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In vitro prenatal developmental toxicity induced by some petroleum substances is mediated by their 3- to 7-ring PAH constituent with a potential role for the aryl hydrocarbon receptor (AhR) by Kamelia, Lenny, de Haan, Laura, Ketelslegers, Hans B., Rietjens, Ivonne. M.C.M., Boogaard, Peter J.

“…•This study evaluates the in vitro developmental toxicity potency of a series of petroleum substances extracts using alternative testing strategies.•In vitro…”
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The role of receptor‐mediated activities of 4‐ and 5‐ring unsubstituted and methylated polycyclic aromatic hydrocarbons (PAHs) in developmental toxicity by Fang, Jing, Wang, Danlei, Kramer, Nynke I., Rietjens, Ivonne M. C. M., Boogaard, Peter J., Kamelia, Lenny

“…The present study evaluated the aryl hydrocarbon receptor (AhR), estrogen receptor‐α (ER‐α), and retinoic acid receptor (RAR) mediated activities of nine 4‐…”
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Developmental toxicity testing of the fume condensate extracts of bitumen and oxidized asphalt in a series of in vitro alternative assays by Kamelia, Lenny, Rietjens, Ivonne.M.C.M., Boogaard, Peter J.

“…The potential developmental toxicity and mode-of-action of fume condensate extracts of bitumen and oxidized asphalt were evaluated in the aryl hydrocarbon…”
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In vitro developmental toxicity potencies of petroleum substances in the embryonic stem cell test as compared to their in vivo developmental toxicity potencies by Kamelia, Lenny, Louisse, Jochem, Rietjens, Ivonne M.C.M., Boogaard, Peter J.

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The Role of Polycyclic Aromatic Hydrocarbons in Developmental Toxicity of Petroleum Substances by Kamelia, Lenny

“…REACH requires prenatal developmental toxicity (PDT) testing for substances registered in the EU at a volume of ≥100 tonnes/year. One of the consequences is…”
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Prenatal developmental toxicity testing of petroleum substances: Application of the mouse embryonic stem cell test (EST) to compare in vitro potencies with potencies observed in vivo by Kamelia, Lenny, Louisse, Jochem, de Haan, Laura, Rietjens, Ivonne M.C.M., Boogaard, Peter J.

“…Prenatal developmental toxicity (PDT) as observed with some petroleum substances (PS) has been associated with the presence of 3–7 ring polycyclic aromatic…”
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Assessment of the in vitro developmental toxicity of diethylstilbestrol and estradiol in the zebrafish embryotoxicity test by Adam, Aziza Hussein Bakheit, de Haan, Laura H.J., Louisse, Jochem, Rietjens, Ivonne M.C.M., Kamelia, Lenny

“…The present study investigated the developmental toxicity of diethylstilbestrol (DES) in the zebrafish embryotoxicity test (ZET). This was done to investigate…”
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The role of metabolism in the developmental toxicity of polycyclic aromatic hydrocarbon‐containing extracts of petroleum substances by Kamelia, Lenny, Haan, Laura, Spenkelink, Bert, Bruyneel, Ben, Ketelslegers, Hans B., Boogaard, Peter J., Rietjens, Ivonne M.C.M.

“…In vitro assays presently used for prenatal developmental toxicity (PDT) testing only assess the embryotoxic potential of parent substances and not that of…”
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Hazard assessment of Maerua subcordata (Gilg) DeWolf. for selected endpoints using a battery of in vitro tests by Gebrelibanos Hiben, Mebrahtom, Kamelia, Lenny, de Haan, Laura, Spenkelink, Bert, Wesseling, Sebastiaan, Vervoort, Jacques, Rietjens, Ivonne M.C.M.

“…Maerua subcordata (Gilg) DeWolf is a medicinal and wild food plant growing mainly in east Africa. Especially its root tuber is widely used in traditional…”
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The subchronic toxicity of higher olefins in Han Wistar rats by Shi, Quan, Penman, Michael G, Carrillo, Juan-Carlos, Van Rompay, An R, Kamelia, Lenny, Rooseboom, Martijn, Shen, Hua, Jia, Sophie, Tian, Yuan, Dunn, Jamie, Hubert, Fabienne, Boogaard, Peter J

“…Higher olefins (HO) are a category of unsaturated hydrocarbons widely used in industry applications to make products essential for daily human life…”
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