Combining cutaneous silent periods with quantitative sudomotor axon reflex testing in the assessment of diabetic small fiber neuropathy

Combining cutaneous silent periods with quantitative sudomotor axon reflex testing in the assessment of diabetic small fiber neuropathy

Highlights • Routine electrophysiological testing cannot assess small nerve fiber types (Aδ and C). These fibers are commonly affected earlier in diabetic small fiber neuropathy (SFN). • Non-invasive tests such as CSP and QSART can directly evaluate these fiber types. • Combining these two tests can...

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Bibliographic Details
Published in:Clinical neurophysiology Vol. 126; no. 5; pp. 1047 - 1053
Main Authors: Kamel, J.T, Vogrin, S.J, Knight-Sadler, R.J, Willems, N.K, Seiderer, L, Cook, M.J, MacIsaac, R.J, Roberts, L.J
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ireland Ltd 01-05-2015
Subjects:
Adult
Aged
Axons - physiology
Case-Control Studies
Diabetes
Diabetic Neuropathies - physiopathology
Erythromelalgia - physiopathology
Female
Humans
Male
Middle Aged
Neural Conduction
Neurology
Neuropathic pain
Reflex
Skin - innervation
Small fiber neuropathy
Small fiber neuropathy
Diabetes
Neuropathic pain
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Summary:Highlights • Routine electrophysiological testing cannot assess small nerve fiber types (Aδ and C). These fibers are commonly affected earlier in diabetic small fiber neuropathy (SFN). • Non-invasive tests such as CSP and QSART can directly evaluate these fiber types. • Combining these two tests can detect SFN from diabetes and impaired glucose tolerance.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2014.09.011