Search Results - "Kamel, Amin"

P156 - In vitro metabolism of bardoxolone, an activator of NRF2 via reversible covalent modification of KEAP1: Formation of bardoxolone epoxide and novel metabolic pathway for oxidative denitrilation via reductive addition of glutathione by Kamel, Amin

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In Vitro Biotransformation of the Nrf2 Activator Bardoxolone: Formation of an Epoxide Metabolite That Undergoes Two Novel Glutathione-Mediated Metabolic Pathways: Epoxide Reduction and Oxidative Elimination of Nitrile Moiety by Kamel, Amin M, Bowlin, Stephen, Anwar, Ban, Reichard, Holly, Argus, Joe, Blair, Ian A

“…Metabolism of bardoxolone methyl (BARD-Me), an oleanolic acid derivative, and its epoxide metabolite was studied in different in vitro systems. BARD-Me also…”
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An improved genetic algorithm for optimizing total supply chain cost in inventory location routing problem by Ahmad Sayed Saif-Eddine, Mohammed Mostafa El-Beheiry, Amin Kamel El-Kharbotly

“…Integrating inventory, location, and routing decisions in supply chains may considerably impact their performance. In this paper, the Inventory Location…”
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Prediction of Mass Spectral Response Factors from Predicted Chemometric Data for Druglike Molecules by Cramer, Christopher J., Johnson, Joshua L., Kamel, Amin M.

“…A method is developed for the prediction of mass spectral ion counts of drug-like molecules using in silico calculated chemometric data. Various chemometric…”
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Inhibition of cytochrome P450 enzymes and biochemical aspects of mechanism-based inactivation (MBI) by Kamel, Amin, Harriman, Shawn

“…Bioactivation of the methylenedioxy portion of paxil to the carbene reactive intermediate and subsequent quasi-irreversible inactivation of P450 enzymes via…”
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Contribution of hepatic FMO-1 in the metabolism of compound 1. Implication of clearance mechanism and extrapolation of metabolism data from preclinical species to humans by Bowlin, Steve, Kozminski, Kirk, Kamel, Amin

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Downstream metabolism of a glutathione conjugate of an arene oxide intermediate by Bowlin, Steve, Hosea, Natalie, McConn, Donavon, Kamel, Amin

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High performance liquid chromatography/atmospheric pressure ionization/tandem mass spectrometry (HPLC/API/MS/MS) in drug metabolism and toxicology by Kamel, Amin, Prakash, Chandra

“…Studies of the metabolic fate of drugs and other xenobiotics in living systems may be divided into three broad areas: (1) elucidation of biotransformation…”
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Bioactivation of 6-fluoro-1H-indazole to quinone methide intermediate: Oxidative defluorination via an arene oxide formation by Bowlin, Steve, Kozminski, Kirk, Apostol, Shane Alexis, Kamel, Amin

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Improving the decision-making process in the structural modification of drug candidates: enhancing metabolic stability by Nassar, Alaa-Eldin F., Kamel, Amin M., Clarimont, Caroline

“…Metabolite characterization has become one of the key drivers of the drug discovery process, helping to optimize ADME properties and increase the success rate…”
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Reduction and methylation of ziprasidone by glutathione, aldehyde oxidase, and thiol s-methyltransferase in humans: an in vitro study by Obach, R. Scott, Prakash, Chandra, Kamel, Amin M.

“…In humans, approximately two-thirds of the metabolic clearance of ziprasidone proceeds through reduction of the N-S bond of the benzisothiazole moiety, which…”
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Novel Identities of Bernoulli Polynomials Involving Closed Forms for Some Definite Integrals by Abd-Elhameed, Waleed Mohamed, Amin, Amr Kamel

“…This paper presents new results of Bernoulli polynomials. New derivative expressions of some celebrated orthogonal polynomials and other polynomials are given…”
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Evaluation of rat brain subcellular fractions for the prediction of in vivo drug metabolism in brain by Shadid, Mohammad, Liu, Ying, Veizaj, Elvana, Huang, Jiansheng, Johnson, Josh, Kamel, Amin

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Eighth-Kind Chebyshev Polynomials Collocation Algorithm for the Nonlinear Time-Fractional Generalized Kawahara Equation by Abd-Elhameed, Waleed Mohamed, Youssri, Youssri Hassan, Amin, Amr Kamel, Atta, Ahmed Gamal

“…In this study, we present an innovative approach involving a spectral collocation algorithm to effectively obtain numerical solutions of the nonlinear…”
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Novel Formulas of Schröder Polynomials and Their Related Numbers by Abd-Elhameed, Waleed Mohamed, Amin, Amr Kamel

“…This paper explores the Schröder polynomials, a class of polynomials that produce the famous Schröder numbers when x=1. The three-term recurrence relation and…”
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Spectral Solutions of Even-Order BVPs Based on New Operational Matrix of Derivatives of Generalized Jacobi Polynomials by Abd-Elhameed, Waleed Mohamed, Badah, Badah Mohamed, Amin, Amr Kamel, Alsuyuti, Muhammad Mahmoud

“…The primary focus of this article is on applying specific generalized Jacobi polynomials (GJPs) as basis functions to obtain the solution of linear and…”
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New Formulas and Connections Involving Euler Polynomials by Abd-Elhameed, Waleed Mohamed, Amin, Amr Kamel

“…The major goal of the current article is to create new formulas and connections between several well-known polynomials and the Euler polynomials. These…”
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Improving the decision-making process in structural modification of drug candidates: reducing toxicity by NASSAR, Alaa-Eldin F, KAMEL, Amin M, CLARIMONT, Caroline

“…The rule of three, relating to activity-exposure-toxicity, presents the single most difficult challenge in the design and advancement of drug candidates to the…”
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Numerical Contrivance for Kawahara-Type Differential Equations Based on Fifth-Kind Chebyshev Polynomials by Abd-Elhameed, Waleed Mohamed, Alkhamisi, Seraj Omar, Amin, Amr Kamel, Youssri, Youssri Hassan

“…This article proposes a numerical algorithm utilizing the spectral Tau method for numerically handling the Kawahara partial differential equation. The double…”
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Collisionally-Induced Dissociation of Substituted Pyrimidine Antiviral Agents: Mechanisms of Ion Formation Using Gas Phase Hydrogen/Deuterium Exchange and Electrospray Ionization Tandem Mass Spectrometry by Kamel, Amin M., Munson, Burnaby

“…ESI and CID mass spectra were obtained for four pyrimidine nucleoside antiviral agents and the corresponding compounds in which the labile hydrogens were…”
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