Search Results - "Kamboj, Rajender"

Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis by Kanoje, Vijay, Pandey, Dilip, Wagh, Akshaya, Patra, Sukanya, Kumar Marisetti, Ajit, Reddy, Madhusudhan, Samant, Charudatt, Mahajan, Nilesh, Gholve, Milind, Sabde, Sudeep, Trivedi, Sneha, Bhankhede, Trupti, Patil, Vinod, Nigade, Prashant, Modi, Dipak, Mehta, Maneesh, Ahirrao, Prajakta, Tota, Swathi, Nanda, Bidyut, Pawar, Shashikant, Polawar, Anuradha, Tamane, Kaustubh, Kuldharan, Sandip, Vishwase, Gururaj, Jana, Nirmal, Mahangare, Sachin J., Vidhate, Prashant, Lagad, Dipak, Gundu, Jayasagar, Phukan, Samiron, Shukla, Manojkumar, Narasimham, Lakshmi, Nemmani, Kumar V.S., Bhonde, Mandar, Sharma, Sharad, Kamboj, Rajender K., Palle, Venkata P.

“…PI3Kδ plays a critical role in adaptive immune cell activation and function. Suppression of PI3Kδ has been shown to counter excessive triggering of immune…”
Get full text

LL-00066471, a novel positive allosteric modulator of α7 nicotinic acetylcholine receptor ameliorates cognitive and sensorimotor gating deficits in animal models: Discovery and preclinical characterization by Verma, Mahip K., Goel, Rajan N., Bokare, Anand M., Dandekar, Manoj P., Koul, Sarita, Desai, Sagar, Tota, Santoshkumar, Singh, Nilendra, Nigade, Prashant B., Patil, Vinod B., Modi, Dipak, Mehta, Maneesh, Gundu, Jayasagar, Walunj, Sameer S., Karche, Navnath P., Sinha, Neelima, Kamboj, Rajender K., Palle, Venkata P.

“…α7 nicotinic acetylcholine receptor (α7 nAChR) is an extensively validated target for several neurological and psychiatric conditions namely, dementia and…”
Get full text

Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors by Zhang, Zaihui, Kodumuru, Vishnumurthy, Sviridov, Serguei, Liu, Shifeng, Chafeev, Mikhail, Chowdhury, Sultan, Chakka, Nagasree, Sun, Jianyu, Gauthier, Simon J., Mattice, Maryanne, Ratkay, Laszlo G., Kwan, Rainbow, Thompson, Jay, Cutts, Alison Brownlie, Fu, Jianmin, Kamboj, Rajender, Goldberg, Y. Paul, Cadieux, Jay A.

“…Inhibition of intestinal brush border DMT1 offers a novel therapeutic approach to the prevention and treatment of disorders of iron overload. Several series of…”
Get full text

A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission by Bleakman, David, Clarke, Vernon R. J, Ballyk, Barbara A, Hoo, Ken H, Mandelzys, Allan, Pellizzari, Andrew, Bath, Catherine P, Thomas, Justyn, Sharpe, Erica F, Davies, Ceri H, Ornstein, Paul L, Schoepp, Darryle D, Kamboj, Rajender K, Collingridge, Graham L, Lodge, David

“…The principal excitatory neurotransmitter in the vertebrate central nervous system, L-glutamate, acts on three classes of ionotripic glutamate receptors, named…”
Get full text

Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat by Owolabi, J B, Rizkalla, G, Tehim, A, Ross, G M, Riopelle, R J, Kamboj, R, Ossipov, M, Bian, D, Wegert, S, Porreca, F, Lee, D K

“…There is growing evidence that nerve growth factor (NGF) may function as a mediator of persistent pain states. We have identified a novel nonpeptidic molecule,…”
Get more information

Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro : Stereospecificity and selectivity profiles by BLEAKMAN, D, BALLYK, B. A, LODGE, D, SCHOEPP, D. D, PALMER, A. J, BATH, C. P, SHARPE, E. F, WOOLLEY, M. L, BUFTON, H. R, KAMBOJ, R. K, TARNAWA, I

“…The activity and selectivity of the glutamate receptor antagonists belonging to the 2,3-benzodiazepine class of compounds have been examined at recombinant…”
Get full text

Design and Synthesis of a Novel Series of 1,2-Disubstituted Cyclopentanes as Small, Potent Potentiators of 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic Acid (AMPA) Receptors by Shepherd, Timothy A, Aikins, James A, Bleakman, David, Cantrell, Buddy E, Rearick, John P, Simon, Richard L, Smith, Edward C. R, Stephenson, Gregory A, Zimmerman, Dennis M, Mandelzys, Allan, Jarvie, Keith R, Ho, Ken, Deverill, Michelle, Kamboj, Rajender K

“…2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) potentiators are ligands that act as positive allosteric modulators at the AMPA receptors. We…”
Get full text

Prototypic G Protein-Coupled Receptor for the Intestinotrophic Factor Glucagon-Like Peptide 2 by Munroe, Donald G., Gupta, Ashwani K., Kooshesh, Fatemeh, Vyas, Tejal B., Rizkalla, Geihan, Wang, Hong, Demchyshyn, Lidia, Yang, Zhi-Jie, Kamboj, Rajender K., Chen, Hongyun, McCallum, Kirk, Sumner-Smith, Martin, Drucker, Daniel J., Crivici, Anna

“…Glucagon-like peptide 2 (GLP-2) is a 33-aa proglucagon-derived peptide produced by intestinal enteroendocrine cells. GLP-2 stimulates intestinal growth and…”
Get full text

Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors by Ornstein, Paul L, Zimmerman, Dennis M, Arnold, M. Brian, Bleisch, Thomas J, Cantrell, Buddy, Simon, Richard, Zarrinmayeh, Hamideh, Baker, S. Richard, Gates, Mary, Tizzano, Joseph P, Bleakman, David, Mandelzys, Allan, Jarvie, Kieth R, Ho, Ken, Deverill, Michelle, Kamboj, Rajender K

Get full text

4-Alkyl- and 4-Cinnamylglutamic Acid Analogues Are Potent GluR5 Kainate Receptor Agonists by Pedregal, Concepción, Collado, Iván, Escribano, Ana, Ezquerra, Jesús, Domínguez, Carmen, Mateo, Ana I, Rubio, Almudena, Baker, S. Richard, Goldsworthy, John, Kamboj, Rajender K, Ballyk, Barbara A, Hoo, Ken, Bleakman, David

“…Enantiomerically pure (2S,4R)-4-substituted glutamic acids were prepared and tested for homomeric GluR5 and GluR6 kainate subtype receptor affinity. Some of…”
Get full text

Discovery of LNP1892: A Precision Calcimimetic for the Treatment of Secondary Hyperparathyroidism by Shukla, Manojkumar R., Sadasivam, Gayathri, Sarde, Ankush, Sayyed, Majid, Pachpute, Vipul, Phadtare, Ramesh, Walke, Navanath, Chaudhari, Vinod D., Loriya, Rajesh, Khan, Talha, Gote, Ganesh, Pawar, Chetan, Tryambake, Mahadeo, Mahajan, Nilesh, Gandhe, Amruta, Sabde, Sudeep, Pawar, Shashikant, Patil, Vinod, Modi, Dipak, Mehta, Maneesh, Nigade, Prashant, Modak, Vijay, Ghodke, Ravindra, Narasimham, Lakshmi, Bhonde, Mandar, Gundu, Jayasagar, Goel, Rajan, Shah, Chirag, Kulkarni, Sanjeev, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P.

“…The calcium sensing receptor (CaSR) plays an important role in maintaining calcium homeostasis. The use of calcimimetic cinacalcet has been established to…”
Get full text

4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists by Baker, S.Richard, Bleakman, David, Ezquerra, Jesus, Ballyk, Barbara A, Deverill, Michele, Ho, Ken, Kamboj, Rajender K, Collado, Ivan, Domı́nguez, Carmen, Escribano, Ana, Mateo, Ana I, Pedregal, Concepcion, Rubio, Almudena

“…Twenty-four 4-alkylidene glutamic acids were synthesised and tested as potential subtype selective GluR5 and 6 ligands. It was found that a critical size of…”
Get full text

A Deep Dive into the Conformational Dynamics of CYP3A4 : Understanding the Binding of Homotropic and Non‐homotropic Ligands for Mitigating Drug‐Drug interaction (DDI) by Koulgi, Shruti, Jani, Vinod, Phukan, Samiron, Sonavane, Uddhavesh, Joshi, Rajendra, Kamboj, Rajender Kumar, Palle, Venkata

“…Cytochrome P450 (CYP) enzymes are well known for metabolism of drugs. The present study attempts to understand the homotropic cooperativity of CYP3A4 inhibitor…”
Get full text

Dual PI3Kδγ inhibition demonstrates potent anticancer effects in diffuse large B-cell lymphoma models: Discovery and preclinical characterization of LL-00084282 by Verma, Mahip K., Samant, Charudatt, Kale, Ramesh, Patra, Sukanya, Mahajan, Nilesh, Gholve, Milind K., Marisetti, Ajitkumar, Sunkara, Brahmam, Naik, Aditya, Shingare, Manisha, Reddy, Madhusudhan, Bokare, Anand M., Akarte, Atul, Koul, Sarita, Nigade, Prashant B., Patil, Vinod B., Modi, Dipak, Ahirrao, Prajakta, Pawar, Shashikant, Kuldharan, Sandip, Dinchhana, Lal, Mehta, Maneesh, Gundu, Jayasagar, Jana, Nirmal, Vidhate, Prashant, Mahangare, Sachin Jaysing, Shukla, Manojkumar R., Goel, Rajan N., Bhonde, Mandar, Kamboj, Rajender Kumar, Palle, Venkata P.

“…Phosphoinositide 3-kinase (PI3K) pathway mediates key signaling events downstream to B-cell receptor (BCR) for survival of mature B-cells, and overexpression…”
Get full text

Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate by Ramdas, Vidya, Talwar, Rashmi, Banerjee, Moloy, Joshi, Advait Arun, Das, Amit Kumar, Walke, Deepak Sahebrao, Borhade, Prashant, Dhayagude, Usha, Loriya, Rajesh, Gote, Ganesh, Bommakanti, Apparao, Sivaram, Aruna, Agarwal, Gautam, Goswami, Arnab, Nigade, Prashant, Mehta, Maneesh, Patil, Vinod, Modi, Dipak, Kumar, Hemant, Mallurwar, Sadanand, Dash, Amruta, Modi, Falguni, Kuldharan, Sandip, Srivastava, Pratima, Singh, Minakshi, Narasimham, Lakshmi, Gundu, Jayasagar, Sharma, Sharad, Kamboj, Rajender Kumar, Palle, Venkata P

“…The identification of a novel class of potent pan-genotypic NS5A inhibitors with good pharmacokinetic profile suitable for potential use in treating HCV…”
Get full text

Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzene­sulfonamide]: Structure–Activity Relationship and Preclinical Characterization by Sinha, Neelima, Karche, Navnath P, Verma, Mahip Kalyan, Walunj, Sameer S, Nigade, Prashant B, Jana, Gourhari, Kurhade, Sanjay P, Hajare, Anil K, Tilekar, Ajay R, Jadhav, Ganesh R, Thube, Baban R, Shaikh, Javed S, Balgude, Sudhakar, Singh, Lairikyengbam Bikramjit, Mahimane, Vijaya, Adurkar, Shridhar K, Hatnapure, Girish, Raje, Firoj, Bhosale, Yogesh, Bhanage, Dnyaneshwar, Sachchidanand, Sachchidanand, Dixit, Ruchi, Gupta, Rajesh, Bokare, Anand M, Dandekar, Manoj, Bharne, Ashish, Chatterjee, Manavi, Desai, Sagar, Koul, Sarita, Modi, Dipak, Mehta, Maneesh, Patil, Vinod, Singh, Minakshi, Gundu, Jayasagar, Goel, Rajan N, Shah, Chirag, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P

“…The discovery of a series of thiophenephenyl­sulfonamides as positive allosteric modulators (PAM) of α7 nicotinic acetylcholine receptor (α7 nAChR) is…”
Get full text

Discovery of a Potent and Selective PI3Kδ Inhibitor ( S )-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4 H -quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models by Shukla, Manojkumar R, Patra, Sukanya, Verma, Mahip, Sadasivam, Gayathri, Jana, Nirmal, Mahangare, Sachin J, Vidhate, Prashant, Lagad, Dipak, Tarage, Anand, Cheemala, Murthy, Kulkarni, Chaitanya, Bhagwat, Shankar, Chaudhari, Vinod D, Sayyed, Majid, Pachpute, Vipul, Phadtare, Ramesh, Gole, Gopal, Phukan, Samiron, Sunkara, Brahmam, Samant, Charudatt, Shingare, Manisha, Naik, Aditya, Trivedi, Sneha, Marisetti, Ajit Kumar, Reddy, Madhusudhan, Gholve, Milind, Mahajan, Nilesh, Sabde, Sudeep, Patil, Vinod, Modi, Dipak, Mehta, Maneesh, Nigade, Prashant, Tamane, Kaustubh, Tota, Swati, Goyal, Hemant, Volam, Harish, Pawar, Shashikant, Ahirrao, Prajakta, Dinchhana, Lal, Mallurwar, Sadanand, Akarte, Atul, Bokare, Anand, Kanhere, Rupesh, Reddy, Neetinkumar, Koul, Sarita, Dandekar, Manoj, Singh, Minakshi, Bernstein, Peter R, Narasimham, Lakshmi, Bhonde, Mandar, Gundu, Jayasagar, Goel, Rajan, Kulkarni, Sanjeev, Sharma, Sharad, Kamboj, Rajender Kumar, Palle, Venkata P

“…PI3Kδ inhibitors have been approved for B-cell malignancies like CLL, small lymphocytic lymphoma, and so forth. However, currently available PI3Kδ inhibitors…”
Get full text

Differential RNA editing efficiency of AMPA receptor subunit GluR-2 in human brain by Nutt, S L, Kamboj, R K

“…RNA editing in rat brain has been found to control a determinant of cation flow in alpha-amino-3-hydroxy-5-methyl-4-isoxasolepropionic acid (AMPA)-gated…”
Get more information

Discovery of a Potent and Selective PI3Kδ Inhibitor (S)‑2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl‑4H‑quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models by Shukla, Manojkumar R, Patra, Sukanya, Verma, Mahip, Sadasivam, Gayathri, Jana, Nirmal, Mahangare, Sachin J, Vidhate, Prashant, Lagad, Dipak, Tarage, Anand, Cheemala, Murthy, Kulkarni, Chaitanya, Bhagwat, Shankar, Chaudhari, Vinod D, Sayyed, Majid, Pachpute, Vipul, Phadtare, Ramesh, Gole, Gopal, Phukan, Samiron, Sunkara, Brahmam, Samant, Charudatt, Shingare, Manisha, Naik, Aditya, Trivedi, Sneha, Marisetti, Ajit Kumar, Reddy, Madhusudhan, Gholve, Milind, Mahajan, Nilesh, Sabde, Sudeep, Patil, Vinod, Modi, Dipak, Mehta, Maneesh, Nigade, Prashant, Tamane, Kaustubh, Tota, Swati, Goyal, Hemant, Volam, Harish, Pawar, Shashikant, Ahirrao, Prajakta, Dinchhana, Lal, Mallurwar, Sadanand, Akarte, Atul, Bokare, Anand, Kanhere, Rupesh, Reddy, Neetinkumar, Koul, Sarita, Dandekar, Manoj, Singh, Minakshi, Bernstein, Peter R, Narasimham, Lakshmi, Bhonde, Mandar, Gundu, Jayasagar, Goel, Rajan, Kulkarni, Sanjeev, Sharma, Sharad, Kamboj, Rajender Kumar, Palle, Venkata P

“…PI3Kδ inhibitors have been approved for B-cell malignancies like CLL, small lymphocytic lymphoma, and so forth. However, currently available PI3Kδ inhibitors…”
Get full text

Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro‑N‑(2′-methyl-3′-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1′-biphenyl]-4-yl)benzamide. Structure–Activity Relationship and Preclinical Characterization by Khedkar, Nilesh Raghunath, Irlapatti, Nageswara Rao, Dadke, Disha, Kanoje, Vijay, Shaikh, Zubair, Karche, Vijay, Shinde, Vikas, Deshmukh, Gokul, Patil, Amit, Jachak, Santosh, Phukan, Samiron, Kizhakinagath, Praveenkumar Anidil, Gholve, Milind, Bhankhede, Trupti, Daler, Jagadeesh, Nemade, Harshal Narendra, Budhe, Sagar, Pareek, Himani, Yeshodharan, Rajesh, Gupta, Rajesh, Kalia, Anil, Pandey, Dilip, Wagh, Akshaya, Kumar, Swaroop, Patil, Vinod, Modi, Dipak, Sharma, Nidhi, Ahirrao, Prajakta, Mehta, Maneesh, Kumar, Hemant, Nigade, Prashant, Tamane, Kaustubh, Mallurwar, Sadanand, Kuldharan, Sandip, Pawar, Shashikant, Vishwase, Gururaj, Bokan, Sanjay, Singh, Minakshi, Naik, Kumar, Ingawale, Sachin, Shankar, Rajesh, Kamalakannan, Prabakaran, Venugopal, Spinvin, George, Shaji K, Padiya, Kamlesh J, Nemmani, Kumar V. S, Gundu, Jaysagar, Bhonde, Mandar, Narasimham, Lakshmi, Sindkhedkar, Milind, Shah, Chirag, Sinha, Neelima, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P

“…The role of calcium release-activated calcium (CRAC) channels is well characterized and is of particular importance in T-cell function. CRAC channels are…”
Get full text