Search Results - "Kamble, Prasad G"

Altered hormonal and autonomic nerve responses to hypo- and hyperglycaemia are found in overweight and insulin-resistant individuals and may contribute to the development of type 2 diabetes by Lundqvist, Martin H., Almby, Kristina, Wiklund, Urban, Abrahamsson, Niclas, Kamble, Prasad G., Pereira, Maria J., Eriksson, Jan W.

“…Aims/hypothesis Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes…”
Get full text

CABLES1 expression is reduced in human subcutaneous adipose tissue in obesity and type 2 diabetes but may not directly impact adipocyte glucose and lipid metabolism by Hetty, Susanne, Vranic, Milica, Kamble, Prasad G, Lundqvist, Martin H, Pereira, Maria J, Eriksson, Jan W

“…Cdk5 and Abl enzyme substrate 1 (CABLES1) is a cell cycle regulator that has previously been identified as a candidate gene for obesity-related phenotypes, but…”
Get full text

Genotype-based recall to study metabolic effects of genetic variation: a pilot study of PPARG Pro12Ala carriers by Kamble, Prasad G., Gustafsson, Stefan, Pereira, Maria J., Lundkvist, Per, Cook, Naomi, Lind, Lars, Franks, Paul W., Fall, Tove, Eriksson, Jan W., Ingelsson, Erik

“…Aim: To assess practical implications of genotype-based recall (GBR) studies, an increasingly popular approach for in-depth characterization of…”
Get full text

Direct effects of glucagon on glucose uptake and lipolysis in human adipocytes by Pereira, Maria J., Thombare, Ketan, Sarsenbayeva, Assel, Kamble, Prasad G., Almby, Kristina, Lundqvist, Martin, Eriksson, Jan W.

“…We aim to investigate the expression of the glucagon receptor (GCGR) in human adipose tissue, and the impact of glucagon in glucose uptake and lipolysis in…”
Get full text

Glucagon Levels During Short-Term SGLT2 Inhibition Are Largely Regulated by Glucose Changes in Patients With Type 2 Diabetes by Lundkvist, Per, Pereira, Maria J, Kamble, Prasad G, Katsogiannos, Petros, Langkilde, Anna Maria, Esterline, Russell, Johnsson, Eva, Eriksson, Jan W

“…The mechanism mediating sodium glucose cotransporter-2 (SGLT2) inhibitor-associated increase in glucagon levels is unknown. To assess short-term effects on…”
Get full text

Early Changes in Adipose Tissue Morphology, Gene Expression, and Metabolism After RYGB in Patients With Obesity and T2D by Katsogiannos, Petros, Kamble, Prasad G, Boersma, Gretha J, Karlsson, F Anders, Lundkvist, Per, Sundbom, Magnus, Pereira, Maria J, Eriksson, Jan W

“…Abstract Context Roux-en-Y gastric bypass (RYGB) surgery effectively prevents or treats type 2 diabetes (T2D). Adipose tissue (AT) mechanisms may be of…”
Get full text

Role of Estrogen and Its Receptors in Adipose Tissue Glucose Metabolism in Pre- and Postmenopausal Women by Ahmed, Fozia, Kamble, Prasad G, Hetty, Susanne, Fanni, Giovanni, Vranic, Milica, Sarsenbayeva, Assel, Kristófi, Robin, Almby, Kristina, Svensson, Maria K, Pereira, Maria J, Eriksson, Jan W

“…Reduced estrogen levels in postmenopausal women predispose them to metabolic side effects, including insulin resistance and type 2 diabetes; however, the…”
Get full text

Changes in Circulating Cytokines and Adipokines After RYGB in Patients with and without Type 2 Diabetes by Katsogiannos, Petros, Kamble, Prasad G., Pereira, Maria J., Sundbom, Magnus, Carlsson, Per‐Ola, Eriksson, Jan W., Espes, Daniel

“…Objective This study aimed to compare cytokine and adipokine levels in patients with obesity with and without type 2 diabetes (T2D) at baseline and 6 months…”
Get full text

Estrogen interacts with glucocorticoids in the regulation of lipocalin 2 expression in human adipose tissue. Reciprocal roles of estrogen receptor α and β in insulin resistance? by Kamble, Prasad G., Pereira, Maria J., Almby, Kristina, Eriksson, Jan W.

“…The adipokine lipocalin 2 (LCN2) is linked to insulin resistance. Its expression in human adipose tissue (AT) can be regulated in a sex-specific manner by a…”
Get full text

Proof-of-concept for CRISPR/Cas9 gene editing in human preadipocytes: Deletion of FKBP5 and PPARG and effects on adipocyte differentiation and metabolism by Kamble, Prasad G., Hetty, Susanne, Vranic, Milica, Almby, Kristina, Castillejo-López, Casimiro, Abalo, Xesús M., Pereira, Maria J., Eriksson, Jan W.

“…CRISPR/Cas9 has revolutionized the genome-editing field. So far, successful application in human adipose tissue has not been convincingly shown. We present a…”
Get full text

Time Course of Metabolic, Neuroendocrine, and Adipose Effects During 2 Years of Follow-up After Gastric Bypass in Patients With Type 2 Diabetes by Almby, Kristina E, Katsogiannos, Petros, Pereira, Maria J, Karlsson, F. Anders, Sundbom, Magnus, Wiklund, Urban, G.Kamble, Prasad, Eriksson, Jan W

“…Abstract Context Roux-en-Y gastric bypass surgery (RYGB) markedly improves glycemia in patients with type 2 diabetes (T2D), but underlying mechanisms and…”
Get full text

Sleep apnea in men is associated with altered lipid metabolism, glucose tolerance, insulin sensitivity, and body fat percentage by Kamble, Prasad G., Theorell-Haglöw, Jenny, Wiklund, Urban, Franklin, Karl A., Hammar, Ulf, Lindberg, Eva, Eriksson, Jan W.

“…Purpose Obstructive sleep apnea (OSA) is associated with obesity and risk for type 2 diabetes. In this community-based study, we thoroughly investigated fatty…”
Get full text

Rapid changes in neuroendocrine regulation may contribute to reversal of type 2 diabetes after gastric bypass surgery by Katsogiannos, Petros, Kamble, Prasad G., Wiklund, Urban, Sundbom, Magnus, Espes, Daniel, Hammar, Ulf, Karlsson, F. Anders, Pereira, Maria J., Eriksson, Jan W.

“…Objective To explore the role of hormones and the autonomic nervous system in the rapid remission of diabetes after Roux-en-Y Gastric Bypass (RYGB). Research…”
Get full text

CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage? by Pereira, MARIA J., VRANIC, MILICA, KAMBLE, PRASAD G., JERNOW, HENNING, KRISTÓFI, ROBIN, HOLBIKOVA, EMA, SKRTIC, STANKO, KULLBERG, JOEL, SVENSSON, MARIA K., HETTY, SUSANNE, ERIKSSON, JAN W.

“…CDKN2C/p18 (Cyclin-Dependent Kinase Inhibitor 2C) is a cell growth regulator that controls cell cycle progression and has previously been associated with…”
Get full text

Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance by Sidibeh, Cherno O., Pereira, Maria J., Lau Börjesson, Joey, Kamble, Prasad G., Skrtic, Stanko, Katsogiannos, Petros, Sundbom, Magnus, Svensson, Maria K., Eriksson, Jan W.

“…We recently showed that the peripheral cannabinoid receptor type 1 ( CNR1 ) gene is upregulated by the synthetic glucocorticoid dexamethasone. CNR1 is highly…”
Get full text

Lipocalin 2 produces insulin resistance and can be upregulated by glucocorticoids in human adipose tissue by Kamble, Prasad G., Pereira, Maria J., Sidibeh, Cherno O., Amini, Sam, Sundbom, Magnus, Börjesson, Joey Lau, Eriksson, Jan W.

“…The adipokine lipocalin 2 is linked to obesity and metabolic disorders. However, its role in human adipose tissue glucose and lipid metabolism is not explored…”
Get full text

A Randomized Controlled Trial of Dapagliflozin Plus Once-Weekly Exenatide Versus Placebo in Individuals with Obesity and Without Diabetes: Metabolic Effects and Markers Associated with Bodyweight Loss by Pereira, Maria J., Lundkvist, Per, Kamble, Prasad G., Lau, Joey, Martins, Julian G., Sjöström, C. David, Schnecke, Volker, Walentinsson, Anna, Johnsson, Eva, Eriksson, Jan W.

“…Introduction The sodium-glucose cotransporter 2 inhibitor dapagliflozin and the glucagon-like peptide-1 (GLP-1) receptor agonist exenatide reduce bodyweight…”
Get full text

Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers by Pillon, Nicolas J, Sardón Puig, Laura, Altıntaş, Ali, Kamble, Prasad G, Casaní-Galdón, Salvador, Gabriel, Brendan M, Barrès, Romain, Conesa, Ana, Chibalin, Alexander V, Näslund, Erik, Krook, Anna, Zierath, Juleen R

“…Obesity and elevated circulating lipids may impair metabolism by disrupting the molecular circadian clock. We tested the hypothesis that lipid overload may…”
Get full text

Role of peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism in human adipose tissue: assessment of adipogenesis and adipocyte glucose and lipid turnover by Kamble, Prasad G., Pereira, Maria J., Gustafsson, Stefan, Lundkvist, Per, Castillejo-López, Casimiro, Fall, Tove, Ingelsson, Erik, Eriksson, Jan W.

“…The protective mechanisms of peroxisome proliferator-activated receptor gamma (PPARγ) Pro12Ala polymorphism in type 2 diabetes (T2D) are unclear. We obtained…”
Get full text

Regulation of Lipocalin 2 by Estrogen in Human Adipose Tissue—A Link between Erß Pathway and Insulin Resistance by KAMBLE, PRASAD G., PEREIRA, MARIA J., BOERSMA, GRETHA J., ALMBY, KRISTINA E., ERIKSSON, JAN W.

“…We recently showed that the adipokine lipocalin 2 (LCN2) causes insulin resistance in human adipose tissue (AT). Its expression is induced by dexamethasone…”
Get full text